Reduced P3 amplitudes are associated with both a family history of alcoholism and antisocial personality disorder

Multifactorial Determinants of Target and Novelty-Evoked P300 Amplitudes in Children of Addicted Parents

“…In contrast, externalizing problem behavior appeared to be a powerful contributor to the prediction of target-P300, indicating reduced target-P300 amplitudes among adolescents with increased levels of externalizing problem behavior. This finding corroborates previous research demonstrating P300 amplitude reductions among teenagers with a conduct disorder or other externalizing symptoms [ 70 , 71 , 72 , 73 ], whereas having a family history of SUD, even in individuals from more densely affected families, had no significant effects [ 71 ]. Externalizing problems and (risk for) substance use frequently co-occur, and there is well-replicated evidence for the existence of a coherent genetic externalizing liability, with a shared variance across broad externalizing symptoms that also includes SUDs [ 74 , 75 , 76 , 77 ].…”

Multifactorial Determinants of Target and Novelty-Evoked P300 Amplitudes in Children of Addicted Parents

“…In contrast, externalizing problem behavior appeared to be a powerful contributor to the prediction of target-P300, indicating reduced target-P300 amplitudes among adolescents with increased levels of externalizing problem behavior. This finding corroborates previous research demonstrating P300 amplitude reductions among teenagers with a conduct disorder or other externalizing symptoms [ 70 , 71 , 72 , 73 ], whereas having a family history of SUD, even in individuals from more densely affected families, had no significant effects [ 71 ]. Externalizing problems and (risk for) substance use frequently co-occur, and there is well-replicated evidence for the existence of a coherent genetic externalizing liability, with a shared variance across broad externalizing symptoms that also includes SUDs [ 74 , 75 , 76 , 77 ].…”

Frontal P300 decrements, alcohol dependence, and antisocial personality disorder

“…This hypothesis was also confirmed. Our finding is consistent with previous P300 findings deriving from studies of adolescents with conduct disorder (Bauer and Hesselbrock 1999a), young healthy adults with ASPD (Bauer et al 1994a(Bauer et al , 1994bHesselbrock et al 1993;O'Connor et al 1994), and cocaine-dependent subjects with comorbid ASPD (Bauer 1997). The frontal focus of the P300 decrement is likewise consistent with demonstrations of frontal PET or SPECT abnormalities among violent criminals (Raine et al 1994(Raine et al , 1998) and among alcoholics with comorbid ASPD (Kuruoglu et al 1996).…”

Subtypes of Family History and Conduct Disorder Effects on P300 During the Stroop Test

“…Unfortunately, when subjects are selected using this strategy, the resulting sample is likely to be confounded by high rates and severe forms of conduct disorder or ASPD (Bauer and Hesselbrock 1997). In the present study, and in numerous previous studies, we have shown that there is no residual effect of either a family history of alcohol (Bauer 1997;Bauer et al 1994aBauer et al , 1994bO'Connor et al 1994) or drug (Bauer and Hesselbrock in press) dependence, or of familial density of alcohol or drug dependence (Bauer and Hesselbrock in press), when the confounding effects of conduct disorder/ASPD are taken into account.…”

Multifactorial Determinants of Target and Novelty-Evoked P300 Amplitudes in Children of Addicted Parents

“…In contrast, externalizing problem behavior appeared to be a powerful contributor to the prediction of target-P300, indicating reduced target-P300 amplitudes among adolescents with increased levels of externalizing problem behavior. This finding corroborates previous research demonstrating P300 amplitude reductions among teenagers with a conduct disorder or other externalizing symptoms [ 70 , 71 , 72 , 73 ], whereas having a family history of SUD, even in individuals from more densely affected families, had no significant effects [ 71 ]. Externalizing problems and (risk for) substance use frequently co-occur, and there is well-replicated evidence for the existence of a coherent genetic externalizing liability, with a shared variance across broad externalizing symptoms that also includes SUDs [ 74 , 75 , 76 , 77 ].…”

Frontal P300 decrements, alcohol dependence, and antisocial personality disorder

“…This hypothesis was also confirmed. Our finding is consistent with previous P300 findings deriving from studies of adolescents with conduct disorder (Bauer and Hesselbrock 1999a), young healthy adults with ASPD (Bauer et al 1994a(Bauer et al , 1994bHesselbrock et al 1993;O'Connor et al 1994), and cocaine-dependent subjects with comorbid ASPD (Bauer 1997). The frontal focus of the P300 decrement is likewise consistent with demonstrations of frontal PET or SPECT abnormalities among violent criminals (Raine et al 1994(Raine et al , 1998) and among alcoholics with comorbid ASPD (Kuruoglu et al 1996).…”

Subtypes of Family History and Conduct Disorder Effects on P300 During the Stroop Test

“…Unfortunately, when subjects are selected using this strategy, the resulting sample is likely to be confounded by high rates and severe forms of conduct disorder or ASPD (Bauer and Hesselbrock 1997). In the present study, and in numerous previous studies, we have shown that there is no residual effect of either a family history of alcohol (Bauer 1997;Bauer et al 1994aBauer et al , 1994bO'Connor et al 1994) or drug (Bauer and Hesselbrock in press) dependence, or of familial density of alcohol or drug dependence (Bauer and Hesselbrock in press), when the confounding effects of conduct disorder/ASPD are taken into account.…”

Multifactorial Determinants of Target and Novelty-Evoked P300 Amplitudes in Children of Addicted Parents

“…In contrast, externalizing problem behavior appeared to be a powerful contributor to the prediction of target-P300, indicating reduced target-P300 amplitudes among adolescents with increased levels of externalizing problem behavior. This finding corroborates previous research demonstrating P300 amplitude reductions among teenagers with a conduct disorder or other externalizing symptoms [ 70 , 71 , 72 , 73 ], whereas having a family history of SUD, even in individuals from more densely affected families, had no significant effects [ 71 ]. Externalizing problems and (risk for) substance use frequently co-occur, and there is well-replicated evidence for the existence of a coherent genetic externalizing liability, with a shared variance across broad externalizing symptoms that also includes SUDs [ 74 , 75 , 76 , 77 ].…”

Frontal P300 decrements, alcohol dependence, and antisocial personality disorder

“…This hypothesis was also confirmed. Our finding is consistent with previous P300 findings deriving from studies of adolescents with conduct disorder (Bauer and Hesselbrock 1999a), young healthy adults with ASPD (Bauer et al 1994a(Bauer et al , 1994bHesselbrock et al 1993;O'Connor et al 1994), and cocaine-dependent subjects with comorbid ASPD (Bauer 1997). The frontal focus of the P300 decrement is likewise consistent with demonstrations of frontal PET or SPECT abnormalities among violent criminals (Raine et al 1994(Raine et al , 1998) and among alcoholics with comorbid ASPD (Kuruoglu et al 1996).…”

Subtypes of Family History and Conduct Disorder Effects on P300 During the Stroop Test

“…Unfortunately, when subjects are selected using this strategy, the resulting sample is likely to be confounded by high rates and severe forms of conduct disorder or ASPD (Bauer and Hesselbrock 1997). In the present study, and in numerous previous studies, we have shown that there is no residual effect of either a family history of alcohol (Bauer 1997;Bauer et al 1994aBauer et al , 1994bO'Connor et al 1994) or drug (Bauer and Hesselbrock in press) dependence, or of familial density of alcohol or drug dependence (Bauer and Hesselbrock in press), when the confounding effects of conduct disorder/ASPD are taken into account.…”