Abstract:Background and Purpose Lapatinib, a widely-used dual inhibitor of
EGFR/ERBB1 and HER2/ERBB2 effectively targeting HER2 positive breast
cancer, has been seriously limited due to cutaneous toxicity. However,
the specific mechanism of lapatinib-induced cutaneous toxicity has not
been clarified, leading to a lack of effective strategy targets to
improve clinical safety. Here, we aimed to identify molecular mechanism
occurs in this process and strive for effective intervention strategies
against lapatinib-induced c… Show more
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