Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia

Spoletini, Ilaria; Cherubini, Andrea; Paola, Margherita Di; Banfi, G.; Rüsch, Nicolas; Martinotti, Giovanni; Bria, Pietro; Rubino, I. Alex; Siracusano, Alberto; Caltagirone, Carlo; Spalletta, Gianfranco

doi:10.1016/j.schres.2008.11.011

Cited by 57 publications

(35 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various studies showed increased functional connectivity in clinical populations associated with performance deficits in cognitive tasks (Schlösser et al, 2003(Schlösser et al, , 2008Meyer-Lindenberg et al, 2005;Shaw et al, 2009). In addition, decreased task-related coupling in clinical conditions such as schizophrenia is presumably compensated by increased connectivity in other networks (Friston, 1998;Stephan et al, 2006;Spoletini et al, 2009). Model-free analyses of connectivity patterns, e.g., using independent component analysis, could provide a more complete picture of differences in connectivity patterns between genetic groups to evaluate this compensation hypothesis directly.…”

Section: Discussionmentioning

confidence: 99%

Frontostriatal Involvement in Task Switching Depends on Genetic Differences in D2 Receptor Density

Stelzel

Basten²,

Montag³

et al. 2010

J. Neurosci.

143

136

View full text Add to dashboard Cite

Recent studies suggest an association of dopamine D2 receptor (DRD2) availability with flexibility in reward-based learning. We extend these results by demonstrating an association of genetically based differences in DRD2 density with the ability to intentionally switch between nonrewarded tasks: noncarriers of the A1 allele of the DRD2/ANKK1-TaqIa polymorphism, associated with higher DRD2 density, show increased task-switching costs, increased prefrontal switching activity in the inferior frontal junction area, and increased functional connectivity in dorsal frontostriatal circuits, relative to A1 allele carriers. A DRD2 haplotype analysis in the same sample confirmed these results, indicating an association between high D2 density and increased task-switching effort. Our results provide evidence that converges with that from association studies relating increased D2 density to deficits in cognitive flexibility in schizophrenia. We suggest that individual differences in striatal D2 signaling in healthy humans modulate goal-directed gating to prefrontal cortex, thus leading to individual differences in switching intentionally to newly relevant behaviors.

show abstract

Section: Discussionmentioning

confidence: 99%

Frontostriatal Involvement in Task Switching Depends on Genetic Differences in D2 Receptor Density

Stelzel

Basten²,

Montag³

et al. 2010

J. Neurosci.

143

136

View full text Add to dashboard Cite

show abstract

“…Moreover, the loss of the modulatory effects of the anterior cingulate on fronto-temporal cooperation has been reported [Fletcher et al, 1999]. Morphological interdependencies between prefrontal and temporal areas are also disturbed in schizophrenia [Woodruff et al, 1997], and gray matter reduction in prefrontal regions has been found to be associated with corresponding findings of abnormal morphological connections between frontal and temporal structures [Spoletini et al, 2009].…”

Section: Figurementioning

confidence: 99%

Source‐based morphometry of gray matter volume in men with first‐episode schizophrenia

Kašpárek

Mareček

Schwarz

et al. 2009

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Detailed information on the diagnostic process is described elsewhere (Marini et al, 2008;Spoletini et al, 2008). Severity of schizophrenia symptoms was assessed by using the Positive and Negative Syndrome Scale (PANSS) (Kay et al, 1987).…”

Section: Subjectsmentioning

confidence: 99%

“…(Freedman, 2003;Marini et al, 2008;Spoletini et al, 2008). One of the factors contributing to the development of schizophrenia is thought to be oxidative damage to neuronal cells.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

Gravina

Spoletini

Masini

et al. 2011

Psychiatry Research

Self Cite

View full text Add to dashboard Cite

Oxidative damage is thought to play a role in the predisposition to schizophrenia. We determined if the polymorphisms of the GSTP1, GSTM1, GSTT1 and GSTA1 genes, which affect the activity of these enzymes against oxidative stress, have a role as susceptibility genes for schizophrenia, analyzing 138 schizophrenic patients and 133 healthy controls. We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.

show abstract

Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia

Cited by 57 publications

References 106 publications

Frontostriatal Involvement in Task Switching Depends on Genetic Differences in D2 Receptor Density

Frontostriatal Involvement in Task Switching Depends on Genetic Differences in D2 Receptor Density

Source‐based morphometry of gray matter volume in men with first‐episode schizophrenia

Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

Contact Info

Product

Resources

About