Reduced forward output states affect the left ventricular opacification of intravenously administered albunex

Gandhok, Navjeet; Block, Romy; Ostoic, Tracy; Rawal, Manoj; Hickle, Patrick; Devries, Stephen; Feinstein, Steven B.

doi:10.1016/s0894-7317(97)80029-6

Cited by 19 publications

(8 citation statements)

References 15 publications

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“…Air-lled microspheres, such as constitute Albunex, are susceptible to decreases in size due to diffusion and destruction by ventricular systolic pressure and acoustic pressure during fundamen-tal ultrasound imaging. 17,18 Signi cantly greater duration of contrast has been achieved with per uoropropane-lled albumin microspheres (Optison), 6 as well as with other microbubble preparations that contain uorocarbon gases, which have low solubility and diffusivity and are more pressure resistant. 1 9,20 Studies have shown that such agents are more effective than Albunex for improving delineation of endocardial border.…”

Section: Discussionmentioning

confidence: 99%

Multicenter Evaluation of SonoVue for Improved Endocardial Border Delineation

Nanda

Wistran²,

Karlsberg³

et al. 2002

Echocardiography

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Section: Discussionmentioning

confidence: 99%

Multicenter Evaluation of SonoVue for Improved Endocardial Border Delineation

Nanda

Wistran²,

Karlsberg³

et al. 2002

Echocardiography

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“…In patients with low cardiac output states, signi cant left ventricular cavity opaci cation is observed in less than 50%. 19 In other patients, the agent has a short effective half-life, generally persisting for several cardiac cycles only, with loss of contrast effect in the left ventricle during systole. 19 Studies indicate that Albunex is extremely pressure sensitive; high left ventricular pressures during systole result in either bubble destruction, bubble compression, or an accelerated rate of air diffusion with loss of contrast effect.…”

Section: Albunexmentioning

confidence: 99%

Current and Future Contrast Agents

Grayburn

2002

Echocardiography

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This article focuses on current and new contrast agents for opacification of left-sided cardiac chambers and myocardium after intravenous injection. The first generation of contrast agents, such as agitated saline, hydrogen peroxide, indocyanine green dye, and iodinated contrast, required aortic or intracoronary injection to opacify the left heart. Second generation agents, such as sonicated 5% human albumin-containing air bubbles, were capable of transpulmonary passage but often failed to produce adequate imaging of the left heart. Newer agents containing fluorocarbon gases within albumin, surfactant, lipid, or polymer shells hold great promise to achieve myocardial perfusion via intravenous injection. The characteristics of these agents and the results of early clinical trials will be discussed.

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“…Für jedes dieser Segmente wurde die Wandbewegung als normo-, hyper-, hypo-, a-, oder dyskinetisch klassifiziert (21 Für jede Schnittebene wurden jeweils 9 ml Kontrastmittellösung verwendet. Die Dosis wurde aufgrund früherer Studienergebnisse mit diesem Kontrastmittel gewählt (4,6,9,29,30). Das Kontrastmittel wurde über eine flexible Verweilkanüle (20G) in der rechten V. cubitalis mit einer Injektionsrate von 1 ml/s injiziert.…”

Section: Herzkatheteruntersuchungunclassified

“…4 Zunahme der Genauigkeit der echokardiographischen biplanen Bestimmung der Ejektionsfraktion durch die Kontrastmittelgabe im Vergleich zur biplanen linksventrikulären Kineventrikulographie Tab. 2 Reproduzierbarkeit der echokardiographischen Beurteilung der 9 Wandsegmente: Abweichungen zwischen den Untersuchern (9,11,24). In der vorliegenden Untersuchung war lediglich bei 3 Patienten die Ejektionsfraktion unter 30 %.…”

Section: Diskussionunclassified

Klinische Wertigkeit der intravenösen Kontrastmittelechokardiographie zur Quantifizierung der linksventrikulären Volumina und Funktion bei Patienten mit reduzierter echokardiographischer Bildqualität

Dittmann

Seipel²

1999

Z Kardiol

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In the present study, we investigated whether the intravenous injection of air-filled albumin microspheres (Infoson) as a contrast medium improves the echocardiographic quantification of left ventricular enddiastolic and endsystolic volumes, stroke volume, ejection fraction, and regional wall motion in patients with suboptimal endocardial border definition on echocardiography. In 30 adult patients, apical two and four chamber views were performed. In comparison to biplane cineventriculography enddiastolic and endsystolic volumes, stroke volume, ejection fraction, and regional wall function were assessed for heart cycles with and without left ventricular contrast. In comparison to biplane cineventriculography echocardiography underestimates enddiastolic (167+/-64 ml, 111+/-43; p<0.0001) and endsystolic volumes (77+/-63 ml, 54+/-40 ml; p<0.0002), stroke volume (90+/-25 ml, 57+/-17 ml; p<0.0001), and ejection fraction (58+/-16%, 55+/-14%; p<0.03). By contrast echocardiography ejection fraction (58+/-16%) agreed with the angiocardiographically measured ejection fraction. Furthermore, after contrast injection correlations improved between cineventriculography and echocardiography for the assessment of left ventricular enddiastolic volumes (without contrast r = 0.90, SEE = 19 ml; with contrast r = 0.93, SEE = 19 ml), endsystolic volumes (without contrast r = 0.94, SEE = 14 ml; with contrast r = 0.95, SEE = 15 ml), stroke volume (without contrast r = 0.63, SEE = 14 ml; with contrast r = 0.67, SEE = 14 ml), ejection fraction (without contrast r = 0.84, SEE = 8%; with contrast r = 0.88, SEE = 7%), regional wall motion (p<0.01) and its reproducibility (p<0.02). In adult patients with suboptimal endocardial border delineation intravenous contrast echocardiography improves the assessment of left ventricular ejection fraction, regional wall motion, and its reproducibility without severe side effects.

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Reduced forward output states affect the left ventricular opacification of intravenously administered albunex

Cited by 19 publications

References 15 publications

Multicenter Evaluation of SonoVue for Improved Endocardial Border Delineation

Multicenter Evaluation of SonoVue for Improved Endocardial Border Delineation

Current and Future Contrast Agents

Klinische Wertigkeit der intravenösen Kontrastmittelechokardiographie zur Quantifizierung der linksventrikulären Volumina und Funktion bei Patienten mit reduzierter echokardiographischer Bildqualität

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