2000
DOI: 10.1055/s-2000-8352 View full text |Buy / Rent full text
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Abstract: The data of the present study indicate that, despite comparable surgical trauma, the OPCAB revascularization procedure without the use of CPB and cardioplegic arrest significantly reduces the systemic inflammatory response syndrome and early catecholamine requirement. This may contribute to improved organ function, subsequently resulting in improved postoperative recovery from surgical revascularization procedures, particularly in critically ill patients.

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“…The activation of neutrophils constitutes a crucial step in inflammation, and leads to neutrophil sequestration within the tissues. Among the potential advantages of off-pump CABG surgery is that it allows for the attenuation of the systemic inflammatory response [17]. In another study, coronary revascularization with cardiopulmonary bypass (CPB) led to a significantly higher level of TNF-alpha, which was linked with P-selectin and ICAM-1 expression.…”
Section: Discussionmentioning
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“…The activation of neutrophils constitutes a crucial step in inflammation, and leads to neutrophil sequestration within the tissues. Among the potential advantages of off-pump CABG surgery is that it allows for the attenuation of the systemic inflammatory response [17]. In another study, coronary revascularization with cardiopulmonary bypass (CPB) led to a significantly higher level of TNF-alpha, which was linked with P-selectin and ICAM-1 expression.…”
Section: Discussionmentioning
“…Because inflammation also occurs in OPCAB surgery, be it less pronounced compared with on-pump CABG surgery, OPCAB patients remain at risk for a complicated postoperative course. [8][9][10] In this study in OPCAB patients, the authors failed to show an effect of aprotinin on the inflammatory mediators tested. It may be that the absence of contact activation in the OPCAB procedure makes the antiinflammatory action of aprotinin less pronounced.…”
Section: Discussionmentioning
“…Anesthesia induction was with midazolam (0.03 mg/kg), sufentanil (1-1.5 g/kg), propofol target-controlled infusion (starting target concentration of 0.5-1.0 g/mL), and pancuronium (0.1 mg/kg). Anesthesia maintenance was with a continuous propofol infusion (up to target concentration of 2.5 g/mL) and supplemental sufentanil (8)(9)(10) g/kg) and pancuronium. Vaporizers for volatile anesthetics were removed from the ventilator.…”
Section: Methodsmentioning
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“…CABG is conventionally performed with the use of cardiopulmonary bypass (CPB), which has been associated with an increased frequency of complications [1][2][3]. A variety of risk factors has been described to help delineate risk assessment of patients undergoing CABG, including preoperative left ventricular ejection fraction (LVEF) [4,5] and postoperative increase in creatine kinase myocardial band (CK-MB) levels [6][7][8][9][10][11].…”
Section: Introductionmentioning