Reduced Emotional Reactivity in Breast Cancer Survivors with Chronic Neuropathic Pain Following Mindfulness-Based Stress Reduction (MBSR): an fMRI Pilot Investigation

Hatchard, Taylor; Mioduszewski, Ola; Khoo, Eve‐Ling; Romanow, Heather; Shergill, Yaad; Tennant, Emily M; Leeming, Allison; Fang, Zhuo; Poulin, Patricia A.; Smith, Andra

doi:10.1007/s12671-020-01546-9

Cited by 11 publications

(24 citation statements)

References 41 publications

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“…For details, ALFF in the current study was considered to be a reflection of neuroactivities in focal regions ( Zang et al, 2007 ), while ReHo adopted previously may characterize the cohesiveness in neighboring brain regions (i.e., focal connectivity) ( Zang et al, 2004 ). Recent works on clinical population have also imposed the focusing on neural correlates of somatic and attention mechanisms underlying the emotional process ( Hatchard et al, 2020 ). Future studies focusing on clinical phenotypes may provide more specific indicators for detecting the interactive process.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Resting-State Functional Connectivity With Decreased Amplitude of Low-Frequency Fluctuations of the Salience Network in Mindfulness Novices

Gan

Ding

et al. 2022

Front. Hum. Neurosci.

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Mindfulness and accordant interventions are often used as complementary treatments to psychological or psychosomatic problems. This has also been gradually integrated into daily lives for the promotion of psychological well-being in non-clinical populations. The experience of mindful acceptance in a non-judgmental way brought about the state, which was less interfered by a negative effect. Mindfulness practice often begins with focused attention (FA) meditation restricted to an inner experience. We postulate that the brain areas related to an interoceptive function would demonstrate an intrinsic functional change after mindfulness training for the mindful novices along with paying more attention to internal processes. To further explore the influence of mindfulness on the organization of the brain regions, both functional connectivity (FC) in the voxel and the region of interest (ROI) level were calculated. In the current study, 32 healthy volunteers, without any meditation experiences, were enrolled and randomly assigned to a mindfulness-based stress reduction group (MBSR) or control group (CON). Participants in the MBSR group completed 8 weeks of mindfulness-based stress reduction (MBSR) and rated their mindfulness skills before and after MBSR. All subjects were evaluated via resting-state functional MRI (rs-fMRI) in both baselines and after 8 weeks. They also completed a self-report measure of their state and trait anxiety as well as a positive and negative affect. Pre- and post-MBSR assessments revealed a decreased amplitude of low-frequency fluctuations (ALFF) in the right anterior cingulate gyrus (ACC.R), left anterior and posterior insula (aIC.L, pIC.L), as well as left superior medial frontal gyrus (SFGmed.L) in MBSR practitioners. Strengthened FC between right anterior cingulate cortex (ACC.R) and aIC.R was observed. The mean ALFF values of those regions were inversely and positively linked to newly acquired mindful abilities. Along with a decreased negative affect score, our results suggest that the brain regions related to attention and interoceptive function were involved at the beginning of mindfulness. This study provides new clues in elucidating the time of evaluating the brain mechanisms of mindfulness novices.

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Section: Discussionmentioning

confidence: 99%

Enhanced Resting-State Functional Connectivity With Decreased Amplitude of Low-Frequency Fluctuations of the Salience Network in Mindfulness Novices

Gan

Ding

et al. 2022

Front. Hum. Neurosci.

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“…Regarding the characteristics of the selected studies, the year of publication ranged from 1989 to 2021. Most of the studies included a control group of healthy participants [ 2 , 7 , 9 , 25 , 26 , 28 , 73 , 74 , 75 , 76 , 77 , 78 ], although two were uncontrolled clinical trials [ 1 , 28 ]. The location of the studies varied widely: 11 were conducted in Europe (Spain [ 25 , 26 ], United Kingdom [ 69 , 76 , 78 ], Sweden [ 9 ], Germany [ 7 ], Austria [ 2 ], Netherlands [ 28 ], and Belgium [ 1 ]), 1 in the United States [ 77 ], and 4 in Canada [ 27 , 73 , 74 , 75 ].…”

Section: Resultsmentioning

confidence: 99%

“…In terms of the study designs, an experimental design was used in the majority of cases [ 1 , 2 , 25 , 26 , 27 , 28 , 69 , 74 , 75 , 77 , 78 ], although two studies used a factorial design [ 9 , 76 ], one used a case-control design [ 7 ], and one used a pilot randomized controlled trial design [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

“…Greater processing of negative and/or positive words was also observed in patients with FMS [ 79 , 81 ]. Moreover, greater responses were observed in regions related to pain and emotional regulation (the somatosensory region, and the cingulate and prefrontal cortices, among other regions) compared to healthy controls [ 27 , 69 , 73 ]. Specifically, in the presence of negative stimuli with emotional content, patients with chronic pain showed greater activation in the aforementioned brain regions, indicating greater processing of pain and negative emotions in these patients [ 27 , 69 , 73 ].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, greater responses were observed in regions related to pain and emotional regulation (the somatosensory region, and the cingulate and prefrontal cortices, among other regions) compared to healthy controls [ 27 , 69 , 73 ]. Specifically, in the presence of negative stimuli with emotional content, patients with chronic pain showed greater activation in the aforementioned brain regions, indicating greater processing of pain and negative emotions in these patients [ 27 , 69 , 73 ]. Previous evidence indicates that patients with CLBP and FMS have an attentional bias towards negative words with emotional content [ 1 , 2 , 9 , 74 ].…”

Section: Resultsmentioning

confidence: 99%

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Chronic Pain and Emotional Stroop: A Systematic Review

Amaro-Díaz

Montoro

Fischer-Jbali

et al. 2022

JCM

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Chronic pain is an unpleasant sensory and emotional experience that persists for more than 3 months and is often accompanied by symptoms such as depression, fatigue, sleep disturbances, and cognitive impairment. Emotional dysregulation may also be involved in its etiology. Emotions are known to modulate the experience of pain by influencing cognition and behavior (emotional awareness, emotional expression and experience, and verbalizations). A useful task to explore emotional processing and emotional dysregulation is the emotional Stroop task. Despite the large number of studies using this task, their objectives are diverse; it is necessary to integrate them. The main objective of the present systematic review was to determine the extent of the abnormalities in behavioral performance (including attentional biases) and/or brain alterations in patients with chronic pain during the emotional Stroop task. This systematic review was conducted in accordance with the Cochrane Collaboration guidelines and Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. The protocol was previously registered in the Prospective Register of Systematic Reviews (PROSPERO) international database. The selected articles were extracted from the PubMed, Scopus, and Web of Science databases. Fifteen studies were identified as eligible for systematic review. The studies reported alterations in brain regions related to pain and emotional regulation, as well as attentional bias and higher response time latencies (related to the words’ emotional load) in patients with chronic pain. The results confirm the validity of the emotional Stroop task to measure emotions and selective attention. As attentional bias towards negative information is often seen in chronic pain patients, and given the relation between selective attention and greater activation of the brain areas associated with pain and emotional processing, this type of task plays a crucial role in research on emotional and attentional processes among chronic pain patients. Further, attentional bias towards negative information has been associated with higher levels of pain. Taken together, the results suggest the need for cognitive training and an emotional approach to chronic pain therapies, especially targeting attentional biases and negative mood.

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The effect of mindfulness‐based interventions on biomarkers in cancer patients and survivors: A systematic review

Matiz,

Scaggiante,

Conversano

et al. 2024

Stress and Health

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Various reviews and meta‐analyses have shown the positive effects of mindfulness‐based interventions (MBIs) on the mental health of cancer patients and survivors. Some studies have also investigated the impact of MBIs on physiological markers of health in oncology, but a systematic review has not been conducted in this field. The current paper aims to fill this gap in the literature. Following preferred reporting items for systematic reviews and meta‐analyses 2020 guidelines, data were obtained from the databases of Pubmed, Scopus, Web of Science in May 2022. Twenty‐five studies were included. Globally, 35 biomarkers were employed in these studies and were categorized 8 groups (cortisol; blood pressure (BP), heart rate, and respiratory rate; C‐reactive protein; telomere length and telomerase activity (TA); genetic signature; cytokines and hormones; leucocyte activation; leucocyte count and cell subpopulation analysis). In seven of these categories of biomarkers, positive effects of MBIs were observed. The most promising results were obtained for cortisol, BP, TA and pro‐inflammatory gene expression. However, the generally low number of studies per single biomarker limits the possibility to draw reliable conclusions. The present review presents a comprehensive state‐of‐the‐art for MBIs in oncology on biomarkers, confirming MBIs' potential for improving physiological health in cancer patients and survivors besides those already shown in literature on psychological well‐being.

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Reduced Emotional Reactivity in Breast Cancer Survivors with Chronic Neuropathic Pain Following Mindfulness-Based Stress Reduction (MBSR): an fMRI Pilot Investigation

Cited by 11 publications

References 41 publications

Enhanced Resting-State Functional Connectivity With Decreased Amplitude of Low-Frequency Fluctuations of the Salience Network in Mindfulness Novices

Enhanced Resting-State Functional Connectivity With Decreased Amplitude of Low-Frequency Fluctuations of the Salience Network in Mindfulness Novices

Chronic Pain and Emotional Stroop: A Systematic Review

The effect of mindfulness‐based interventions on biomarkers in cancer patients and survivors: A systematic review

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