Reduced electroencephalogram responses to standard and target auditory stimuli in bipolar disorder and the impact of psychotic features: Analysis of event‐related potentials, spectral power, and inter‐trial coherence

Abstract

The results provide neural evidence that BD is associated with disrupted sensory, attentional, and cognitive processing of auditory stimuli, which may be worsened with the presence of psychotic features.

Are there consistent abnormalities in event‐related EEG oscillations in patients with Alzheimer’s disease compared to other diseases belonging to dementia?

“…Notably, the above abnormalities in event-related delta responses may not be specific to patients with dementia. Indeed, similar reductions in delta responses have been found in patients with schizophrenia (Bates et al, 2009;Doege, Jansen, et al, 2010;Doege, Kumar, et al, 2010;Ergen et al, 2008;Ford et al, 2008;Roschke and Fell, 1997) and bipolar disease (Atagün et al, 2014;Lundin et al, 2018). Moreover, patients with alcohol use disorder have been shown to exhibit lower event-related delta responses as compared to CU participants during go/no go (Kamarajan et al, 2004) and visual oddball tasks (Jones et al, 2006).…”

Reduced white matter microstructure in bipolar disorder with and without psychosis

“…11 These findings imply deviations in working memory and context updating 12 for people with psychosis, with additional deviations in salience processing 13 and perceptual encoding 14 for people in the BDP group. Similar studies comparing BDP and BDNP confirm reductions in P300 amplitude to target tones but disagree on the profile of differences: some report reductions for BDP only, 15 while others report P300 reductions for both BDP and BDNP, with these deviations being moderated by family history of psychosis. 16 It remains unclear whether neurophysiological deviations are present exclusively in BDP and thus associated with psychosis or present in both the bipolar groups and thus common to affective disturbance.…”

Special Report on the Impact of the COVID-19 Pandemic on Clinical EEG and Research and Consensus Recommendations for the Safe Use of EEG

“…97 Reduced delta and theta responses during different WM paradigms have also been found in schizophrenia, bipolar disorders and dementia. 107,113,115 Differentiation between clinical populations (specificity) is of course of the greatest importance in a clinical context. Accordingly, compared with controls, patients with FEP increased frontal theta ERS in all WM conditions, 129 while the theta power was reduced in patients diagnosed with ADHD.…”

“…107,108 Reduced delta and theta responses were also reported in bipolar disorder patients during oddball paradigms. [111][112][113] Overall, reductions of delta and theta responses are thought to be a general indicator of pathological brains; reductions of these EEG bands are found not just found in schizophrenia and bipolar patients but also in dementia patients. Patients with MCI, 114,115 patients with Alzheimer's disease, 116,117 and dementia patients with Parkinson's disease 118,119 have also been shown to exhibit reduced delta and theta responses.…”