Reduced DNA repair synthesis in healthy women having first degree relatives with breast cancer

Repair of Tobacco Carcinogen-Induced DNA Adducts and Lung Cancer Risk: a Molecular Epidemiologic Study

“…Compared with all other subgroups analyzed, case patients with a family history of cancer exhibited the lowest DRC, which is consistent with the previously reported low DRC in cancer patients with a positive family history of cancer (20,(45)(46)(47). On the other hand, control subjects with a family history of cancer tended to have a higher DRC than control subjects without a family history of cancer.…”

Repair of Tobacco Carcinogen-Induced DNA Adducts and Lung Cancer Risk: a Molecular Epidemiologic Study

“…Compared with all other subgroups analyzed, case patients with a family history of cancer exhibited the lowest DRC, which is consistent with the previously reported low DRC in cancer patients with a positive family history of cancer (20,(45)(46)(47). On the other hand, control subjects with a family history of cancer tended to have a higher DRC than control subjects without a family history of cancer.…”

Defective DNA Repair in a Large Family Having a High Occurrence of Cancer

“…data], in breast cancer patients [4], and in per sons with first-degree relatives with cancer [5], In this study we have found a high occurrence of defective DNA repair in a large family with first-degree relatives with cancer; the morbidity of cancer in the first generation is higher than in the general population. Members of the first generation had cancer at ages 56 79.…”

Functional characterization of Ape1 variants identified in the human population

“…glance, we emphasize that 20-35% reductions in repair capacity (equivalent to a heterozygote individual possessing one 50% active allele and a fully functional allele) have been shown to associate with a 4-to 6-fold higher risk of developing cancer (19,(21)(22)(23)(24)(25)61). One must also keep in mind that proteins often communicate as members of larger protein networks.…”

Repair of Tobacco Carcinogen-Induced DNA Adducts and Lung Cancer Risk: a Molecular Epidemiologic Study

“…Compared with all other subgroups analyzed, case patients with a family history of cancer exhibited the lowest DRC, which is consistent with the previously reported low DRC in cancer patients with a positive family history of cancer (20,(45)(46)(47). On the other hand, control subjects with a family history of cancer tended to have a higher DRC than control subjects without a family history of cancer.…”

Defective DNA Repair in a Large Family Having a High Occurrence of Cancer

“…data], in breast cancer patients [4], and in per sons with first-degree relatives with cancer [5], In this study we have found a high occurrence of defective DNA repair in a large family with first-degree relatives with cancer; the morbidity of cancer in the first generation is higher than in the general population. Members of the first generation had cancer at ages 56 79.…”

Functional characterization of Ape1 variants identified in the human population

“…glance, we emphasize that 20-35% reductions in repair capacity (equivalent to a heterozygote individual possessing one 50% active allele and a fully functional allele) have been shown to associate with a 4-to 6-fold higher risk of developing cancer (19,(21)(22)(23)(24)(25)61). One must also keep in mind that proteins often communicate as members of larger protein networks.…”

Repair of Tobacco Carcinogen-Induced DNA Adducts and Lung Cancer Risk: a Molecular Epidemiologic Study

“…Compared with all other subgroups analyzed, case patients with a family history of cancer exhibited the lowest DRC, which is consistent with the previously reported low DRC in cancer patients with a positive family history of cancer (20,(45)(46)(47). On the other hand, control subjects with a family history of cancer tended to have a higher DRC than control subjects without a family history of cancer.…”

Defective DNA Repair in a Large Family Having a High Occurrence of Cancer

“…data], in breast cancer patients [4], and in per sons with first-degree relatives with cancer [5], In this study we have found a high occurrence of defective DNA repair in a large family with first-degree relatives with cancer; the morbidity of cancer in the first generation is higher than in the general population. Members of the first generation had cancer at ages 56 79.…”

Functional characterization of Ape1 variants identified in the human population

“…glance, we emphasize that 20-35% reductions in repair capacity (equivalent to a heterozygote individual possessing one 50% active allele and a fully functional allele) have been shown to associate with a 4-to 6-fold higher risk of developing cancer (19,(21)(22)(23)(24)(25)61). One must also keep in mind that proteins often communicate as members of larger protein networks.…”