J. Neurosci. Res. volume 86, issue 14, P3240-3245 2008 DOI: 10.1002/jnr.21762 View full text
Elena Titova, Robert P. Ostrowski, Christopher G. Kevil, Wenni Tong, Hugo Rojas, Lawrence C. Sowers, John H. Zhang, Jiping Tang

Abstract: AbstractMany studies have indicated leukocytes as one of the major contributors to brain injuries caused by intracerebral hemorrhage (ICH). Leukocyte-expressed CD18 is important for neutrophilendothelial interactions in the vasculature and CD18 deficiency protects against ischemiareperfusion injury. We investigated whether CD18 deficiency provides protection against ICHinduced brain injury. Male wild type (WT) CD18+/+ mice and CD18−/− knockout mice were used in this study. ICH was induced by a collagenase inj…

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