Elena Titova, Robert P. Ostrowski, Christopher G. Kevil, Wenni Tong, Hugo Rojas, Lawrence C. Sowers, John H. Zhang, Jiping Tang
AbstractMany studies have indicated leukocytes as one of the major contributors to brain injuries caused by intracerebral hemorrhage (ICH). Leukocyte-expressed CD18 is important for neutrophilendothelial interactions in the vasculature and CD18 deficiency protects against ischemiareperfusion injury. We investigated whether CD18 deficiency provides protection against ICHinduced brain injury. Male wild type (WT) CD18+/+ mice and CD18−/− knockout mice were used in this study. ICH was induced by a collagenase inj…
scite is a Brooklyn-based startup that helps researchers better discover and evaluate scientific articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by researchers from dozens of countries and is funded in part by the National Science Foundation and the National Institute of Drug Abuse of the National Institutes of Health.