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Cited by 51 publications
(31 citation statements)
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References 197 publications
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“…Previous studies demonstrated that MDA was significantly increased in rats with ureteral obstruction compared with sham-treated rats (Shi et al, 2020). ROS production and RIF are enhanced by deficiencies in these antioxidant enzymes (Aranda-Rivera et al, 2021). In our study, UUO led to a decrease in the activities of SOD and GSH-PX compared to those of the sham group.…”
Section: Discussionsupporting
confidence: 58%
“…Previous studies demonstrated that MDA was significantly increased in rats with ureteral obstruction compared with sham-treated rats (Shi et al, 2020). ROS production and RIF are enhanced by deficiencies in these antioxidant enzymes (Aranda-Rivera et al, 2021). In our study, UUO led to a decrease in the activities of SOD and GSH-PX compared to those of the sham group.…”
Section: Discussionsupporting
confidence: 58%
“…The binding of Ang II and AGEs to their receptors activates TGFβ1 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) redox-sensitive signaling pathways (Figure 2) [94]. Furthermore, mtROS can stimulate TGFβ1 through the upregulation of Smad 2/3, inducing its nuclear translocation.…”
Section: Crosstalk Between Noxs and Mitochondria In Kidney Diseasesmentioning
confidence: 99%
“…Both studies showed that the treatment with antioxidants (NAC and curcumin) upregulates biogenesis [47,152,169]. Importantly, NAC and curcumin antioxidants have shown mitochondria protection by promoting bioenergetics preservation and maintaining redox homeostasis to avoid mtROS [16,94]. In 5/6 nephrectomy-induced CKD, the levels of PGC-1α decrease in a temporal course from two days after the nephrectomy, causing reductions in NRF1 and NRF2 [120].…”
Section: Redox-sensitive Proteins Participating In Mitochondrial Biogenesismentioning
confidence: 99%
“…Fibrosis strongly correlates with the deterioration of kidney function, especially oxidative stress [172,173]. Although it is present in several forms of CKD, the mechanisms that induce renal fibrosis are not always the same [174].…”
Section: Evs-induced Oxidative Stress and The Promotion Of Inflammati...mentioning
confidence: 99%