2018
DOI: 10.1002/ame2.12001
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Abstract: In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30% glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) and sorbitol dehydrogenase, respectively. AR reduces glucose to sorbitol at the expense of NADPH, while sorbitol dehydrogenase converts sorbitol to fructose at the expense of NAD+, leading to NADH production. Consumption of NADPH, accumulation of sorbitol, and generation of fructose and NADH have all been implicated in the pathogenesi… Show more

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Cited by 181 publications
(114 citation statements)
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References 115 publications
(155 reference statements)
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“…Excess glucose is also consumed in the polyol pathway, a two-step process that converts glucose first to sorbitol and then to fructose (Yan, 2018). Upregulation of the polyol pathway, specifically its first step, in wooden breast and white striping is supported by an accumulation of sorbitol in the pectoralis major (Abasht et al, 2016;Boerboom et al, 2018).…”
Section: Pathological Shunting Of Glucose To Ancillary Pathwaysmentioning
confidence: 99%
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“…Excess glucose is also consumed in the polyol pathway, a two-step process that converts glucose first to sorbitol and then to fructose (Yan, 2018). Upregulation of the polyol pathway, specifically its first step, in wooden breast and white striping is supported by an accumulation of sorbitol in the pectoralis major (Abasht et al, 2016;Boerboom et al, 2018).…”
Section: Pathological Shunting Of Glucose To Ancillary Pathwaysmentioning
confidence: 99%
“…Most ROS are generated as normal by-products during mitochondrial electron transport, specifically at respiratory complexes I and III of the oxidative phosphorylation pathway (Rousset et al, 2004), and are prevented from reaching damaging levels by various cellular defenses such as superoxide dismutase and glutathione peroxidase (Anderson and Neufer, 2006). Potential genetic variation in antioxidant response may be a key contributor to wooden breast susceptibility in broilers, as altered redox homeostasis can inhibit the activity of anti-oxidant enzymes and increase ROS production at mitochondrial respiratory complex I (Yabe-Nishimura, 1998; Chung, 2004;Yan, 2018). In diabetes, the polyol pathway is believed to play a critical role in oxidative stress and vascular damage due to its derangement of redox homeostasis (Yabe-Nishimura, 1998;Chung, 2004;Yan, 2018).…”
Section: Disruption Of Redox Homeostasis and Oxidative Stressmentioning
confidence: 99%
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“…Further research demonstrated the presence of an active polyol pathway in tissues other than those involved in metabolizing dietary fructose, such as the human brain [98][99][100]. Numerous studies using animal models have linked the polyol pathway to metabolic alterations such as obesity, insulin resistance, diabetes, diabetic nephropathy, chronic kidney disease, acute kidney injury, blood pressure, and MetS [101][102][103][104]. Nonetheless, although the presence of an active polyol pathway has been described in humans, and mounting evidences obtained in animal models of the importance of this pathway in diseases, its significance in human metabolic diseases awaits further confirmation.…”
Section: Relevance Of Endogenous Fructose Production In Human Diseasesmentioning
confidence: 99%
“…Гіперглікемія також призводить до посиленої активації поліолового шляху окиснення глюкози зі зростанням швидкості продукції сорбітолу й фруктози. Останні погано проникають через плазмолему й накопичуються в клітинах, підвищуючи осмолярність, що спричиняє розвиток дегенерації клітин через «гіперосмолярні «вибухи» [15]. Крім того, накопичення сорбітолу в нейронах пригнічує синтез найважливішого компоненту мієліну -міоінозитолу, що є субстратом для синтезу мембранного фосфатидилінозитолу (ендогенного регулювальника мікросомальної Na + K + АТФази), а також для численних різноманітних сигнальних молекулкіназ, які можуть приєднати до інозитолу фосфатну групу.…”
Section: чинники ризику й механізми розвиткуunclassified