Redox‐Controlled Transcription Factors and Gene Expression

Giles, Gregory I.

doi:10.1002/9783527627585.ch11

Cited by 7 publications

(9 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both the antioxidants and the mtDNA repair systems are inducible (Giles 2009;Gredilla et al 2010). Thus, they can be transitorily increased at moments of higher than normal oxidative damage to quickly return to their basal levels when the situation is normalized.…”

Section: Mitochondrial Dna Oxidation and The Caloric Restriction Apprmentioning

confidence: 97%

“…It would be very inefficient to generate large amounts of ROS and, afterwards, try to intercept them before they reach cellular components like DNA, or even worse, try to repair DNA after heavily damaging it. This makes even more sense taking into account that cells possess the ability to regulate and to adjust the gene expression of cellular antioxidants-cell exposition to oxidants can regulates the expression of a large number of genes, typically between 1 and 5% of the genome (Giles 2009)-and the potentially high energetic cost of continuously maintaining high levels of antioxidant and repair molecules in cells (to our knowledge, no data are available about energetic costs to maintain oxidative stress homeostasis for a given animal species).…”

Section: Mitochondrial Ros Production and Animal Longevitymentioning

confidence: 99%

“…Two of these mechanisms deserve a special mention: the regulation of uncoupling protein activity (Echtay et al 2003;Brand et al 2004), and the activation of the antioxidant response signaling pathway (Wakabayashi et al 2004;Copple et al 2008;Giles 2009), both involved in the prevention of oxidative damage effects.…”

Section: Biomembranes and Unsaturated Fatty Acidsmentioning

confidence: 99%

See 2 more Smart Citations

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

Pamplona

Barja

2011

Biogerontology

View full text Add to dashboard Cite

Key mechanisms relating oxidative stress to longevity from an interespecies comparative approach are reviewed. Long-lived animal species show low rates of reactive oxygen species (ROS) generation and oxidative damage at their mitochondria. Comparative physiology also shows that the specific compositional pattern of tissue macromolecules (proteins, lipids and nucleic acids) in long-lived animal species gives them an intrinsically high resistance to modification that likely contributes to their superior longevity. This is obtained in the case of lipids by decreasing the degree of fatty acid unsaturation, and in the case of proteins by lowering their methionine content. These findings are also substantiated from a phylogenomic approach. Nutritional or/and pharmacological interventions focused to modify some of these molecular traits were translated with modifications in animal longevity. It is proposed that natural selection tends to decrease the mitochondrial ROS generation and to increase the molecular resistance to the oxidative damage in long-lived species.

show abstract

Section: Mitochondrial Dna Oxidation and The Caloric Restriction Apprmentioning

confidence: 97%

Section: Mitochondrial Ros Production and Animal Longevitymentioning

confidence: 99%

Section: Biomembranes and Unsaturated Fatty Acidsmentioning

confidence: 99%

See 1 more Smart Citation

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

Pamplona

Barja

2011

Biogerontology

View full text Add to dashboard Cite

show abstract

“…ANTIOXIDANT-RESPONSE ELEMENT AND Nrf2. Redox state is regulated through the action of RS, which act as second messengers in signal transduction networks (77). RS require a receptor site on the target protein, which effectively allows different proteins to function as redox sensors for diverse types of RS.…”

Section: Cellular Protection By Repair/turnover and Detoxifyingmentioning

confidence: 99%

Molecular and structural antioxidant defenses against oxidative stress in animals

Pamplona

Costantini

2011

American Journal of Physiology-Regulatory, Integrative and Comp

275

199

View full text Add to dashboard Cite

In this review, it is our aim 1) to describe the high diversity in molecular and structural antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept of antioxidant to other structural and functional factors affecting the "whole" organism, 3) to incorporate, when supportable by evidence, mechanisms into models of life-history trade-offs and maternal/epigenetic inheritance, 4) to highlight the importance of studying the biochemical integration of redox systems, and 5) to discuss the link between maximum life span and antioxidant defenses. The traditional concept of antioxidant defenses emphasizes the importance of the chemical nature of molecules with antioxidant properties. Research in the past 20 years shows that animals have also evolved a high diversity in structural defenses that should be incorporated in research on antioxidant responses to reactive species. Although there is a high diversity in antioxidant defenses, many of them are evolutionary conserved across animal taxa. In particular, enzymatic defenses and heat shock response mediated by proteins show a low degree of variation. Importantly, activation of an antioxidant response may be also energetically and nutrient demanding. So knowledge of antioxidant mechanisms could allow us to identify and to quantify any underlying costs, which can help explain life-history trade-offs. Moreover, the study of inheritance mechanisms of antioxidant mechanisms has clear potential to evaluate the contribution of epigenetic mechanisms to stress response phenotype variation.

show abstract

“…[31][32][33] So, these aldehydes were believed to produce simply "cytotoxic" effects associated with oxidative stress, but evidence is increasing that these compounds can also have specific signaling roles inducing adaptive responses driven to decrease oxidative damage and improve antioxidant defences. [22,33] Two of these mechanisms are: the regulation of uncoupling protein activity, [34,35] and the activation of the antioxidant response signaling pathway, [36][37][38] both involved in the prevention of oxidative damage effects.…”

Section: Wwwantioxorgmentioning

confidence: 99%

Regulation of Membrane Unsaturation as Antioxidant Adaptive Mechanism in Long-lived Animal Species

Naudí

Jové

Ayala

et al. 2011

Free Radicals and Antioxidants

View full text Add to dashboard Cite

Oxidative stress resulting from biomolecular oxidative damage due to the imbalance between reactive species production and antioxidant response has become an universal constraint of life-history evolution in animals and a modulator of phenotypic development and trade-offs. Redox balance is an important selective pressure faced by most organisms, and a myriad of mechanisms have evolved to regulate and adjust this balance. This diversity of mechanisms means that organisms have a great deal of flexibility in how they deal with reactive species challenges across time, conditions, and tissue types, as well as that different organisms may evolve different strategies for dealing with similar challenges. In the following paragraphs, we review the adaption of biological membranes as structural antioxidant defense against reactive species evolved by animals. In particular, it is our goal to describe the physiological mechanisms underlying the structural adaption of cellular membranes to oxidative stress, to explain the meaning of this adaptive mechanism, and to review the state of the art about the link between membrane composition and longevity of animal species.

show abstract

Redox‐Controlled Transcription Factors and Gene Expression

Cited by 7 publications

References 85 publications

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

Molecular and structural antioxidant defenses against oxidative stress in animals

Regulation of Membrane Unsaturation as Antioxidant Adaptive Mechanism in Long-lived Animal Species

Contact Info

Product

Resources

About