Redox and pH-responsive degradable micelles for dually activated intracellular anticancer drug release

Chen, Wei; Zhong, Ping; Meng, Fenghua; Cheng, Ru; Deng, Chao; Feijén, Jan; Zhong, Zhiyuan

doi:10.1016/j.jconrel.2013.01.001

Cited by 339 publications

(246 citation statements)

References 46 publications

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“…The synthesis of DTPA-BC 16 and Gd-DTPA-BC 16 was carried out by the method of Kimpe et al 24 Gd-FLPNPs were prepared using a previously reported single-step assembly method.…”

Section: Materials and Methods Materialsmentioning

confidence: 99%

“…DSPE-PEG 2k and DSPE-PEG 2k -folate were purchased from Shanghai Advanced Vehicle Technology Co, Ltd (Shanghai, People's Republic of China). mPEG 2k -S-S-C 16 was synthesized using a method reported in our previous studies. 14 The consumables of cell culture in this work were purchased from Beijing Dingguo Changsheng Biotechnology Co, Ltd (Beijing, People's Republic of China).…”

Section: Materials and Methods Materialsmentioning

confidence: 99%

“…In recent years, impressive progress has also been made in the new form and multifunction CA, including micelles, 3,4 macromolecules, 5 supramolecular aggregates, burst of encapsulated drugs caused by the cleavage of disulfide bonds in the redox environment of cancer cells. [16][17][18] Our earlier studies have demonstrated the advantages of the amphiphilic reduction-sensitive polymer of monomethoxypoly-(ethylene glycol)-S-S-hexadecyl (mPEG-S-S-C 16 ) for the effective intracellular delivery of anticancer drugs. 13,19 To further improve the therapeutic efficiency and reduce side effects, a better strategy was to develop moleculartargeted nanoparticle (NP) therapeutic carriers.…”

Section: Introductionmentioning

confidence: 99%

“…Compared to traditional nanoplatforms, Gd-coated folate-targeted lipid-polymer hybrid nanoparticles (Gd-FLPNPs) can simultaneously accomplish specific targeting, controlled release of anticancer drugs, MRI, and simultaneous therapy. The Gd-FLPNPs were composed of a biodegradable hydrophobic poly(d,l-lactide-co-glycolide) (PLGA) core and a paramagnetic liposome shell which was based on gadolinium-diethylenetriaminepentaacetic acidbis-tetradecylamide (Gd-DTPA-BC 16 ), 1,2-distearoyl-snglycero-3-phosphoethanolamine-N-carboxy (polyethylene glycol) 2000-folate (DSPE-PEG 2k -folate), and mPEG-S-S-C 16 . The PLGA core was employed to load and release hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

“…The PLGA core was employed to load and release hydrophobic drugs. The paramagnetic liposome shell offers many advantages such as folate targeting provided by DSPE-PEG 2k -folate, redox-sensitivity provided by mPEG-S-S-C 16 , and contrast-enhanced ability provided by Gd-DTPA-BC 16 . The structure of Gd-FLPNPs is shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

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MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles

Deng

et al. 2017

IJN

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In recent years, there has been increasing interest in developing a multifunctional nanoscale platform for cancer monitoring and chemotherapy. However, there is still a big challenge for current clinic contrast agents to improve their poor tumor selectivity and response. Herein, we report a new kind of Gd complex and folate-coated redox-sensitive lipid-polymer hybrid nanoparticle (Gd-FLPNP) for tumor-targeted magnetic resonance imaging and therapy. Gd-FLPNPs can simultaneously accomplish diagnostic imaging, and specific targeting and controlled release of doxorubicin (DOX). They exhibit good monodispersity, excellent size stability, and a well-defined core-shell structure. Paramagnetic nanoparticles based on gadolinium-diethylenetriaminepentaacetic acid-bis-cetylamine have paramagnetic properties with an approximately two-fold enhancement in the longitudinal relaxivity compared to clinical used Magnevist. For targeted and reduction-sensitive drug delivery, Gd-FLPNPs released DOX faster and enhanced cell uptake in vitro, and exhibited better antitumor effect both in vitro and in vivo.

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“…The synthesis of DTPA-BC 16 and Gd-DTPA-BC 16 was carried out by the method of Kimpe et al 24 Gd-FLPNPs were prepared using a previously reported single-step assembly method.…”

Section: Materials and Methods Materialsmentioning

confidence: 99%

Section: Materials and Methods Materialsmentioning

confidence: 99%