Red vine leaf extract (<scp>AS</scp> 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review

Azhdari, Maryam; Zilaee, Marzie; Karandish, Majid; Hosseini, Seyed Ahmad; Mansoori, Anahita; Zendehdel, Mohadeseh; Khodarahpour, Sara

doi:10.1002/ptr.6705

Cited by 13 publications

(9 citation statements)

References 30 publications

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“…Die klinische Wirksamkeit von Antistax ® wurde in einem systematischen Review anhand von 5 Studien, in die Patienten mit chronischer Veneninsuffizienz (Widmer Klasse I und II) einbezogen wurden, evaluiert [ 1 ], Die einzelnen Studienarme schlossen 36-113 Patienten ein. Sie erhielten über einen Zeitraum von 6-12 Wochen 360mg oder 720mg Antistax® versus Placebo.…”

Section: Ursachen Von Beinödemenunclassified

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Phytotherapie bei chronischen Venenleiden

Vlachojannis¹,

Chrubasik‐Hausmann²

2022

Zeitschrift für Komplementärmedizin

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SummaryBeinödeme können kardiale oder venöse Ursachen haben. Bei chronischen Venenleiden kommen Phlebotonika zum Einsatz. Hier muss zwischen Pflanzenextrakten und extrahierten bzw. synthetischen Pflanzenstoffen differenziert werden, die nicht zu den Phytotherapeutika zählen. In der gerade veröffentlichten überarbeiteten Leitlinie der Gesellschaft für Gefäßchirurgie wurden alle Phlebotonika gemeinsam als empfehlenswerte Behandlung mit gesicherter Wirksamkeit eingestuft. Zu den pflanzlichen Optionen zählen in Europa vor allem Extrakte aus dem Stechenden Mäusedorn (Ruscus aceolatus), der Rosskastanie (Aesculus hippocastanum) und dem Roten Weinlaub (Vitis vinifera). Die Wirksamkeits-Evidenz für Ruscusextrakt ist schlecht und für Rosskastanien und Roten Weinlaubextrakt nur mäßig. Trotzdem würdigte die S2k-Leitlinie aus dem Jahr 2019 den Einsatz der Extrakte aus der Rosskastanie und dem Roten Weinlaub mit dem Hinweis, dass die volle Wirksamkeit erst nach bis zu 4 Wochen eintritt. Deshalb ist es jetzt dringend erforderlich, den ausstehenden Wirksamkeitsnachweis mittels konfirmatorischer Studien für jeden Pflanzenextrakt separat zu erbringen, um die Leitlinien an die Wirksamkeitsevidenz anzupassen.

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Section: Ursachen Von Beinödemenunclassified

“…Die meisten Patienten hatten Antistax® gut vertragen [ 1 ]. Die Behandlung mit Antistax® kann Nausea, Magenschmerzen oder anderen Magen-Darmstörungen zur Folge haben.…”

Section: Ursachen Von Beinödemenunclassified

Phytotherapie bei chronischen Venenleiden

Vlachojannis¹,

Chrubasik‐Hausmann²

2022

Zeitschrift für Komplementärmedizin

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“…Tolerability was reported as good or satisfactory and occurred at similar rates as placebo, with common adverse effects including gastrointestinal distress, hypercholesterolemia, dizziness, malaise, urticaria, and sleep disturbance. Further high-quality trials are needed for more conclusive evidence [ 140 ].…”

Section: Advances In Nonsurgical Management: Conservativementioning

confidence: 99%

Management of Lower Extremity Pain from Chronic Venous Insufficiency: A Comprehensive Review

Orhurhu

Chu²,

Xie

et al. 2021

Cardiol Ther

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Purpose of Review: Chronic venous insufficiency is found to some extent in a large proportion of the world's population, especially in the elderly and obese. Despite its prevalence, little research has been pursued into this pathology when compared to similarly common conditions. Pain is often the presenting symptom of chronic venous insufficiency and has significant deleterious effects on quality of life. This manuscript will describe the development of pain in chronic venous insufficiency, and will also review both traditional methods of pain management and novel advances in both medical and surgical therapy for this disease. Recent Findings: Pain in chronic venous insufficiency is a common complication which remains poorly correlated in recent studies with the clinically observable extent of disease. Although lifestyle modification remains the foundation of treatment for pain associated

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“…The pharmacological interventions usually apply in prediabetic patients without a positive response to lifestyle interventions [2]. Recent researches have shown too much attention to phytochemicals and the antioxidant trace elements to treat and control some diseases (T2DM, prediabetes, metabolic syndrome, CVD, and chronic venous insufficiency (CVI)) [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Curcumin and zinc co-supplementation along with a loss-weight diet can improve lipid profiles in subjects with prediabetes: a multi-arm, parallel-group, randomized, double-blind placebo-controlled phase 2 clinical trial

Karandish

Mozaffari‐Khosravi

Mohammadi

et al. 2022

Diabetol Metab Syndr

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Background Diabetes is one of the major public health concerns. Prediabetes can increase the risk of developing some non-communicable diseases such as type 2 diabetes. Given the increasing trend of prediabetes, it is critical to control it and prevent its complications. Curcumin is a major bioactive component of turmeric. Zinc is an antioxidant nutrient. The present trial aimed to evaluate the effect of curcumin and zinc co-supplementation along with a loss-weight diet on serum lipid profiles in overweight or obese patients with prediabetes. Methods Eighty-four participants were randomized to four groups (curcumin (500 mg/day), zinc (30 mg/day), “curcumin and zinc”, and placebo) for 90 days. Serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), non-HDL, HDL/LDL ratio, weight, BMI, waist circumstance (WC), hip circumstance (HC), physical activity (PA) and dietary intake were determined pre and post-intervention. This study will be conducted at Yazd Diabetes Research Clinic, Shahid Sadoughi University of Medical Sciences. Results Totally, 82 participants were included in the final analysis. After the adjusted PA effect, changes in serum TG (adjusted p = 0.001), LDL (adjusted p = 0.035), non-HDL (adjusted p = 0.003), HDL/LDL ratio (adjusted p = 0.002), and HDL (adjusted p < 0.0001) revealed a significant difference between the groups. However, the changes in weight (adjusted p = 0.004) and BMI (adjusted p = 0.006) were significant but the changes in dietary intake, PA, WC, and HC were non-significant (adjusted p ≥ 0.05). Despite that there was a significant difference for post-intervention HDL levels (adjusted p = 0.016), other lipid profiles showed no significant difference (adjusted p ≥ 0.05). Conclusion The beneficial effects of “curcumin and zinc” co-supplementation was reported for the changes of some lipid profiles (TG, LDL, HDL, non-HDL, and HDL to LDL ratio), BMI, and weight with no positive effects on TC, dietary intake, PA, WC, and HC. Therefore, it may play a potential role in the prevention of macro and microvascular complications. Trial registration The project is a registered clinical trial (Registration number: IRCT20190902044671N1, Iranian Registry of Clinical Trials (IRCT), registered October 11, 2019.

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Red vine leaf extract (AS 195) can improve some signs and symptoms of chronic venous insufficiency, a systematic review

Cited by 13 publications

References 30 publications

Phytotherapie bei chronischen Venenleiden

Phytotherapie bei chronischen Venenleiden

Management of Lower Extremity Pain from Chronic Venous Insufficiency: A Comprehensive Review

Curcumin and zinc co-supplementation along with a loss-weight diet can improve lipid profiles in subjects with prediabetes: a multi-arm, parallel-group, randomized, double-blind placebo-controlled phase 2 clinical trial

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