Aims. Gas-phase metallicities offer insight into the chemical evolution of galaxies, as they reflect the recycling of gas through star formation, galactic inflows and outflows. Environmental effects such as star-formation quenching mechanisms play an important role in shaping the evolution of galaxies. Clusters of galaxies at z < 0.5 are expected to be the sites where environmental effects can be clearly observed with present-day telescopes. Methods. We explore the Frontier Fields cluster RXJ2248-443 at z = 0.348 with VIMOS/VLT spectroscopy from CLASH-VLT, which covers a central region corresponding to almost 2 virial radii. The fluxes of [OII] λ3727, Hβ, [OIII] λ5007, Hα and [NII] λ6584 emission lines were measured allowing the derivation of (O/H) gas metallicities, star formation rates based on extinction-corrected Hα fluxes and active galactic nuclei (AGN) contamination. We compare our sample of cluster galaxies to a population of field galaxies at similar redshifts. Results. We use the location of galaxies in projected phase-space to distinguish between cluster and field galaxies. Both populations follow the star-forming-sequence in the diagnostic diagrams, which allow disentangling between the ionising sources in a galaxy, with only a low number of galaxies classified as Seyfert II. Both field and cluster galaxies follow the "Main-Sequence" of star forming galaxies, with no substantial difference observed between the two populations. In the Mass -Metallicity (MZ) plane, both high mass field and cluster galaxies show comparable (O/H)s to the local SDSS MZ relation, with an offset of low mass galaxies (log(M/M ) < 9.2) towards higher metallicities. While both the metallicities of "accreted" (R < R 500 ) and "infalling" (R > R 500 ) cluster members are comparable at all masses, the cluster galaxies from the intermediate, mass complete bin (9.2 < log(M/M ) < 10.2) show more enhanced metallicities than their field counterparts, by a factor of 0.065 dex, with a ∼ 1.8σ significance. The intermediate mass field galaxies are in accordance with the expected (O/H)s from the Fundamental Metallicity relation, while the cluster members deviate strongly from the model predictions, by a factor of ∼ 0.12 dex. The results of this work are in accordance with studies of other clusters at z < 0.5 and favour the scenario in which the hot halo gas of low and intermediate mass cluster galaxies is removed due to ram pressure stripping, leading to an increase in their gas-phase metallicity.