Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro

Allemand, Alexandra; Leonardi, Bianca Franco; Zimmer, Aline Rigon; Moreno, Susana Elisa; Romão, Pedro Roosevelt Torres; Gosmann, Grace

doi:10.1089/jmf.2015.0101

Cited by 16 publications

(8 citation statements)

References 42 publications

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“…The level of IL-6 in plasma was decreased by 21% by RPSE supplementation but was not significant. Similar to these findings, red pepper extract inhibited the production of nitric oxide and TNF-α induced by lipopolysaccharide/interferon-γ (IFN-γ)-stimulated macrophages in vitro and also reduced inflammation in mice [40]. In addition, red pepper improved antigen-induced inflammation in rats, followed by the inhibition of pro-inflammatory cytokine production at the inflammation site.…”

Section: Rpse Reduced Pro-inflammatory Cytokines Without Hepatotoxicisupporting

confidence: 56%

Red Pepper (Capsicum annuum L.) Seed Extract Improves Glycemic Control by Inhibiting Hepatic Gluconeogenesis via Phosphorylation of FOXO1 and AMPK in Obese Diabetic db/db Mice

et al. 2020

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Obesity is a notable risk factor for developing type 2 diabetes, augmenting the concern of obese diabetes (ObD). Anti-obesity and antioxidant effects of red pepper seeds extract (RPSE) have increased our expectations that RPSE would also improve the pathological phenotypes of obese diabetes. Therefore, we hypothesized that RPSE would have an anti-diabetic effect in ObD mice. Animals were assigned either as follows: (1) db/+, (2) db/db control, (3) RPSE (200 mg/kg bw), or (4) a comparative control (metformin 150 mg/kg bw). RPSE was orally administered daily for 8 weeks. As a result, RPSE supplementation improved diabetic phenotypes, including fasting glucose, hemoglobin (HbA1c), and insulin levels. Pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6), and triglycerides were reduced in RPSE-treated mice. RPSE supplementation also diminished the rate-limiting enzymes of gluconeogenesis, including glucose 6-phosphatas (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), in the liver. RPSE supplementation increased the phosphorylation of forkhead box protein O1 (FOXO1) and AMP-activated protein kinase (AMPK), which underlined the mechanism of the anti-diabetic effects of RPSE. Taken together, RPSE has the potential to improve glycemic control by repressing hepatic gluconeogenesis via the phosphorylation of FOXO1 and AMPK in ObD mice.

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Section: Rpse Reduced Pro-inflammatory Cytokines Without Hepatotoxicisupporting

confidence: 56%

Red Pepper (Capsicum annuum L.) Seed Extract Improves Glycemic Control by Inhibiting Hepatic Gluconeogenesis via Phosphorylation of FOXO1 and AMPK in Obese Diabetic db/db Mice

et al. 2020

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“…The consumption of pepper is growing exponentially due to its organoleptic and nutraceutical properties. Pepper consists of vital medicinal properties such as antioxidant [ 4 ], anticancer [ 5 ], anti-inflammatory [ 6 ], and antiobesity properties [ 7 ]. Owing to its increasing demand, the cultivation of pepper has been increased by 40% in the last decade.…”

Section: Introductionmentioning

confidence: 99%

Next-Generation Sequencing Approaches in Genome-Wide Discovery of Single Nucleotide Polymorphism Markers Associated with Pungency and Disease Resistance in Pepper

Manivannan

Kim

Yang

et al. 2018

BioMed Research International

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Pepper is an economically important horticultural plant that has been widely used for its pungency and spicy taste in worldwide cuisines. Therefore, the domestication of pepper has been carried out since antiquity. Owing to meet the growing demand for pepper with high quality, organoleptic property, nutraceutical contents, and disease tolerance, genomics assisted breeding techniques can be incorporated to develop novel pepper varieties with desired traits. The application of next-generation sequencing (NGS) approaches has reformed the plant breeding technology especially in the area of molecular marker assisted breeding. The availability of genomic information aids in the deeper understanding of several molecular mechanisms behind the vital physiological processes. In addition, the NGS methods facilitate the genome-wide discovery of DNA based markers linked to key genes involved in important biological phenomenon. Among the molecular markers, single nucleotide polymorphism (SNP) indulges various benefits in comparison with other existing DNA based markers. The present review concentrates on the impact of NGS approaches in the discovery of useful SNP markers associated with pungency and disease resistance in pepper. The information provided in the current endeavor can be utilized for the betterment of pepper breeding in future.

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“…According to the scientific literature, pepper extracts have been applied for different purposes, such as repellent and insecticidal agents for pests. In addition, antifungal, antioxidant and anti-inflammatory activities have been reported (Allemand et al, 2016;Batiha et al, 2020;Nidiry, 2022).…”

Section: Pre-emergence Of Cucumis Sativus and Hovenia Dulcismentioning

confidence: 99%

Pre- and post- emergence control of Hovenia dulcis with extracts obtained from pepper (Capsicum baccatum)

Anchieta¹,

Pigatto²,

Baisch³

et al. 2022

Reveng

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This study evaluated the efficiency of extracts obtained from Capsicum baccatum by ultrasound-assisted extraction in the control of Hovenia dulcis, which is an invasive species popularly known in Brazil as “uva-do-japão”. The effects of extraction time (20 – 60 min), maximum power fraction (50 – 100%), and pulse cycle (0.3 – 0.7) were investigated on the activities of extracts. The pre-emergence assays demonstrated inhibition of 45-100% on the 14th day. In the post-emergence, the root and shoot lengths were 3.0 and 2.6 times smaller than the control (without application of extract). The fresh mass and dry mass were 4.7 and 4.2 times lower than the control. All these best results were found in the assay with higher extraction time (60 min) and power fraction (100%), and lower pulse cycle (0.3). Chlorophyll a and b and carotenoids ranged from 0.84 to 1.15, 0.19 to 0.35 and 0.32 to 0.40 mg/g fresh mass, respectively. Overall, it is demonstrated that extracts from Capsicum baccatum presented an inhibitory effect on the germination of Hovenia dulcis. Although the extract did not completely inhibit germination or cause the death of seedlings, it presented an effect against the normal development of seedlings, including the roots and shoots, thus allowing it to be used as a control strategy before germination or for small plants of this invasive species.

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Red Pepper (Capsicum baccatum) Extracts Present Anti-Inflammatory Effects In Vivo and Inhibit the Production of TNF-α and NO In Vitro

Cited by 16 publications

References 42 publications

Red Pepper (Capsicum annuum L.) Seed Extract Improves Glycemic Control by Inhibiting Hepatic Gluconeogenesis via Phosphorylation of FOXO1 and AMPK in Obese Diabetic db/db Mice

Red Pepper (Capsicum annuum L.) Seed Extract Improves Glycemic Control by Inhibiting Hepatic Gluconeogenesis via Phosphorylation of FOXO1 and AMPK in Obese Diabetic db/db Mice

Next-Generation Sequencing Approaches in Genome-Wide Discovery of Single Nucleotide Polymorphism Markers Associated with Pungency and Disease Resistance in Pepper

Pre- and post- emergence control of Hovenia dulcis with extracts obtained from pepper (Capsicum baccatum)

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