Red Fluorescence of Urine in Wood's Light as Aid in Office Diagnosis of Porphyria

Zeligman, Israel

doi:10.1001/archderm.1950.01530120144014

Cited by 9 publications

(1 citation statement)

References 2 publications

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“…Urine containing an increased concentration of porphyrins may be pink, red, or brown. When excited around 400 nm, urine containing porphyrins presents red fluorescence [ 64 ]. So, patients with Covid-19 must present urine with red fluorescence.…”

Section: Covid-19: Ppix Diagnostic Markermentioning

confidence: 99%

SARS-CoV-2, hemoglobin and protoporphyrin IX: Interactions and perspectives

Courrol

Silva

Masilamani

2021

Photodiagnosis and Photodynamic Therapy

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Background SARS-CoV-2 attacks hemoglobin through its structural protein ORF3a, dissociating the iron from the heme, as iron is necessary by cell machinery for virus replication. In this process protoporphyrin (PpIX) is released. Methods The decrease in the hemoglobin levels observed in patients with Covid-19 is frequently accompanied by an increase in PpIX levels. This evidence was confirmed by the quantification of PpIX by high-performance liquid chromatography (HPLC). PpIX emission is observed in its two characteristic bands at approximately 635 nm and 705 nm. Results This paper searches to understand the role of heme and PpIX inside the cells. Perspectives on the use of PpIX fluorescence as a sensor to monitor the presence of SARS-CoV-2 in the tissue, blood, urine, or feces to map the evolution and severity of the disease or to monitor the response of the Covid-19 treatment modalities were described. Conclusion Fluorescence spectroscopy could be adopted as an excellent diagnostic technique for Covid-19, of low cost and high sensitivity. This method can potentially be used as a marker to monitor the response to the treatments. Photodynamic and sonodynamic therapies using the endogenous PpIX increased in the acute phase of the disease, could be employed for Covid-19 treatment.

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Section: Covid-19: Ppix Diagnostic Markermentioning

confidence: 99%