Current Opinion in Hematology volume 18, issue 4, P249-253 2011 DOI: 10.1097/moh.0b013e3283476129 View full text
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Christelle Mazurier, Luc Douay, Hélène Lapillonne

Abstract: Because iPS cells can proliferate indefinitely and can be selected for a phenotype of interest, they are potential candidates to organize complementary sources of RBCs for transfusion. Proof of concept of generating cRBCs from iPS cells has been performed, but the procedures need to be optimized to lead to clinical application in blood transfusion. Several crucial points remain to be resolved. Notably these include the choice of the initial cell type to generate iPS cells, the method of reprogramming, that is,…

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