Red blood cell distribution width predicts early mortality in patients with acute dyspnea

Hong, Namki; Oh, Jaewon; Kang, Seok Min; Kim, Soo Hyuk; Won, Hoyoun; Youn, Jong Chan; Park, Sungha; Jang, Yangsoo; Chung, Namsik

doi:10.1016/j.cca.2012.02.024

Cited by 38 publications

(35 citation statements)

References 35 publications

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“…RDW levels that are higher than 14.8%, was associated with malignancy (p<0.001) (Beyazit et al, 2012). Early mortality rates in patients with acute dyspnea (Hong et al, 2012) and acute pulmonary embolism (Zorlu et al, 2012) were also found associated with high levels of RDW. To obtain more compelling evidence and disclose the true value of RDW levels in specific conditions, more studies are needed with higher volume samples.…”

Section: Discussionmentioning

confidence: 89%

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

Kayilioglu¹,

Dinç²,

Sozen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The Bethesda System for Reporting Thyroid Cytopathology is one of the main classification systems for thyroid nodules. It expects that 7% of all fine needle aspiration biopsies will be reported as atypia or follicular lesions of undetermined significance, and 5-15% of these undetermined nodules are malignant. Our study is a retrospective analysis of variables that may be associated with outcome in patients with indeterminate thyroid nodules. Materials and Methods: Patients who underwent thyroidectomy in our institution between 2010 and 2014 were retrieved from the institutional records database. Patient demographics and medical histories were recorded. All ultrasonography reports were examined for nodule features and biochemical blood levels, hormone levels and complete blood counts were recorded. Results: A total of 103 patient cytopathology reports were regarded as belonging to the undetermined category. Some 35% of patients had malignant nodules. Median preoperative red cell distribution width (RDW) level was 13.6 inthe benign group, while it was 14.3 in patients with malignancy, demonstrating a significant correlation (p=0.003). Only calcification presence was significantly different between benign and malignant groups on ultrasonography (p=0.034). Conclusions: Ultrasonography is one of the primary tools for this matter. RDW levels may become another promising tool to predict malignancy.

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Section: Discussionmentioning

confidence: 89%

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

Kayilioglu¹,

Dinç²,

Sozen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…For the first time in 2007, it was identified as a prognostic marker for all-cause mortality in patients with congestive heart failure 3 . In more recent years, RDW has been associated with mortality and other adverse outcomes in various clinical conditions, including chronic and acute heart failure, acute dyspnea, acute pancreatitis, severe sepsis and septic shock, trauma, acute pulmonary embolism, older adulthood, and even acute kidney injury or kidney transplantation 4–12 . Similarly, results from a single center with 1293 incident PD patients demonstrated that patients with RDW ≥ 15.5% had an adjusted HR of 1.60 for cardiovascular mortality (RDW reference group: <15.5%) 13 .…”

Section: Discussionmentioning

confidence: 99%

Red Cell Distribution Width and Mortality in Hemodialysis Patients

Vashistha

Streja

Molnar

et al. 2016

American Journal of Kidney Diseases

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BACKGROUND Red cell distribution width (RDW) is an index of red blood cell volume variability that has historically been used as a marker of iron-deficiency anemia. More recently, studies have shown that elevated RDW is associated with higher mortality risk in the general population. However, there is lack of data demonstrating the association between RDW and mortality risk in hemodialysis (HD) patients. We hypothesized that higher RDW levels are associated with higher mortality in HD patients. STUDY DESIGN Retrospective observational study using a large HD patient cohort. SETTING & PARTICIPANTS 109,675 adult maintenance HD patients treated in a large dialysis organization January 1, 2007–December 31, 2011. PREDICTOR Baseline and time-varying RDW, grouped into 5 categories: <14.5%, 14.5%–<15.5%, 15.5%–<16.5%, 16.5%–<17.5% and ≥ 17.5%. RDW 15.5%–<16.5% was used as the reference category. OUTCOME All-cause mortality. RESULTS The mean age of study participants was 63±15 (SD) years and the study cohort was 44% female. In baseline and time-varying analyses, there was a graded association between higher RDW levels and incrementally higher mortality risk. Receiver operating characteristic, net reclassification analysis and integrated discrimination improvement analyses demonstrated that RDW is a stronger predictor of mortality as compared with traditional markers of anemia such as hemoglobin, ferritin, and iron saturation. LIMITATIONS Lack of comprehensive data that may be associated with both RDW and HD patient outcomes, such as blood transfusion data, socioeconomic status, and other unknown confounders; therefore the possibility of residual confounding could not be excluded. Also, lack of information on cause of death; thus, cardiovascular mortality outcomes could not be examined. CONCLUSIONS In HD patients, higher RDW levels are associated with incrementally higher mortality risk. RDW is also a stronger predictor of mortality than traditional laboratory markers of anemia. Further studies are needed to determine the mechanisms underlying the association between RDW and mortality.

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“…In numerous recent studies, RDW was found to have extraordinary prognostic value for the prediction of mortality in many clinical conditions (23)(24)(25). In addition, RDW is thought to be a marker for many pathological conditions (rheumatoid arthritis, inflammatory bowel disease, colon cancer, celiac disease, etc.)…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Use of Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis

Ertekin¹,

Kara²,

Erdemir³

et al. 2017

EAJEM

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Red blood cell distribution width predicts early mortality in patients with acute dyspnea

Cited by 38 publications

References 35 publications

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome

Red Cell Distribution Width and Mortality in Hemodialysis Patients

Efficacy of Use of Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis

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