Recurrent skin cancer

Accuracy of biopsy sampling for subtyping basal cell carcinoma

“…Other studies have reported a wide range of incidence of mixed subtypes from 11% to 39%. 7,[12][13][14][15][16] In particular, studies of Mohs excisions of BCC found even a higher incidence (43%) of mixed subtypes. 8 The high incidence of mixed subtype BCC in our studies may be a result of differences in the patient population, tissue sampling, and diagnostic criteria.…”

Prognostic Factors for Metastasis in Squamous Cell Carcinoma of the Skin

“…The significance of differentiation has varied among authors. Some authors believe that poorly differentiated tumors metastasize more frequently (Figures 4 and 5) 8,13–16 . It has been reported that the metastatic rate of poorly differentiated lesions is almost triple that of well‐differentiated lesion and that the 5‐year cure rate for well‐differentiated lesions is far superior to the cure rate for poorly differentiated lesions 8 .…”

Histopathologic Considerations in the Management of Skin Cancer

“…This is seen most often in the deeper part of the lesion where narrow, compressed, invasive strands lie within a dense fibrous stroma. This type of change was the most common histological variant observed in my series of 65 recurrent skin cancers . Since this change is usually in the deeper part of the process, it is not apparent on visual inspection and may go unsuspected.…”

“…Secondary sclerosis (Fig. ) within a nodular basal‐cell epithelioma is an important secondary change which may interfere with accurate diagnosis and effective treatment . It does not produce the same depressed morphea or scar‐like appearance seen in the morpheiform neoplasm, nor carry the same contraindications in treatment, although the sclerosis may at times make curretage difficult and by blurring margins make conventional surgery unsuccessful.…”