Recurrent myelinoclastic diffuse sclerosis: a case report of a child with Schilder's variant of multiple sclerosis

Fitzgerald, Michael J.; Coleman, Lee

doi:10.1007/s002470000346

Cited by 18 publications

(10 citation statements)

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“…reported that only 14% of patients had a monophasic course, and 70% of patients eventually developed definite multiple sclerosis . The first case of relapse of ‘tumefactive’ lesions was reported in a 6‐year‐old boy by Fitzgerald and Coleman . In the current study, 17 patients had a relapsing‐remitting course with recurrence of ‘tumefactive’ lesions rather than small discrete plaque‐like lesions characteristic of multiple sclerosis, with a median time to relapse of 4 months.…”

Section: Discussionsupporting

confidence: 45%

Tumefactive demyelination: clinical, imaging and follow-up observations in thirty-nine patients

et al. 2012

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Section: Discussionsupporting

confidence: 45%

Tumefactive demyelination: clinical, imaging and follow-up observations in thirty-nine patients

et al. 2012

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“…It represents a more acute form of multiple sclerosis and is a very rare disease that occurs especially in children of both sexes. 7,11 The histologic features of brain tissue are identical to those of multiple sclerosis. The most common manifestation is an acute hemiplegia with headache, vomiting, and behavioral deterioration.…”

Section: Discussionmentioning

confidence: 93%

“…Several areas of variable size appear in the cerebellum, brain stem, and central white matter, especially in the periventricular region. [7][8][9] The case presented here fulfilled the diagnostic criteria of multiple sclerosis, but the appearance of lesions on MRI was atypical for multiple sclerosis, with large symmetric hyperintensities extending to the subcortical area that mimic those of Schilder's disease. 10 Schilder's disease is considered to be closely related to multiple sclerosis.…”

Section: Discussionmentioning

confidence: 99%

Schilder's Disease: Case Study With Serial Neuroimaging

et al. 2003

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Schilder's myelinoclastic diffuse sclerosis is a rare sporadic demyelinating disease that usually affects children between 5 and 14 years old. The disease often mimics intracranial neoplasm or abscess. We report a 9-year-old girl with Schilder's disease who presented with left hemiparesis. Cranial computed tomography and magnetic resonance imaging (MRI) showed large lesions in the subcortical white matter of the occipital and parietal lobes of both hemispheres that were indistinguishable from an abscess. A cerebrospinal fluid oligoclonal band test was found positive. A diagnosis of acute disseminated encephalomyelitis was then suspected. Serial MRI examinations revealed regression of parenchymal lesions, but there were new developing corpus callosum lesions. After 2 months, the patient presented with right-sided visual loss. MRI examination revealed a right optic nerve lesion. The patient had a dramatic clinical response to corticosteroid therapy. Subsequent control MRI examination revealed regression of both lesions. At 24 months of observation, the patient continued to do well without any complaints or neurologic sequelae.

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“…Some children have a relentless progressive course, culminating in death. Other children may have remissions and exacerbations, with each subsequent exacerbation more severe and each remission less complete than previous episodes, until death supervenes [59, 60]. Schilder's disease is uniformly fatal [60, 61].…”

Section: Schilder’s Diseasementioning

confidence: 99%

Clinical and Pharmacological Aspects of Inflammatory Demyelinating Diseases in Childhood: An Update

Spalice

Parisi²,

Papetti³

et al. 2010

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Inflammatory demyelinating diseases comprise a spectrum of disorders affecting the myelin of the central and peripheral nervous system. These diseases can usually be differentiated on the basis of clinical, radiological, laboratory and pathological findings. Recent studies have contributed to current awareness that inflammatory demyelinating diseases are not restricted to the adult age group, but are more common in pediatric age than previously believed. Some of pediatric inflammatory demyelinating diseases carry an unfavorable long-term prognosis but appropriate treatments can improve the outcome. The possibility of physical and cognitive disability resulting from these diseases, highlights the urgent need for therapeutic strategies for neurorehabilitation, neuroregeneration, and neurorepair. This review discusses characteristics of primary demyelinating diseases more frequently observed in childhood, focusing on epidemiology, clinical aspects and treatments.

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Recurrent myelinoclastic diffuse sclerosis: a case report of a child with Schilder's variant of multiple sclerosis

Cited by 18 publications

References 0 publications

Tumefactive demyelination: clinical, imaging and follow-up observations in thirty-nine patients

Tumefactive demyelination: clinical, imaging and follow-up observations in thirty-nine patients

Schilder's Disease: Case Study With Serial Neuroimaging

Clinical and Pharmacological Aspects of Inflammatory Demyelinating Diseases in Childhood: An Update

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