Recurrent cutaneous necrotizing eosinophilic vasculitis. A novel eosinophil-mediated syndrome

Cellular and Molecular Dynamics in Exercise-Induced Urticarial Vasculitis Lesions

“…The possibility that eosinophil granule proteins may act on endothelial cells directly is likely because a major contribution of eosinophil granule proteins to tissue damage has been reported in bullous pemphigoid, 16 delayed pressure urticarial lesions, 17 and eosinophilic vasculitis. 18,19 However, it remains inconclusive that the discharge of potentially toxic granule proteins from eosinophils is one of the crucial factors in determining whether urticarial lesions resolve without causing vasculitis or develop into leukocytoclastic vasculitis lesions, because at present we are unable to obtain sequential biopsy specimens from controls with urticarial lesions that are reproduced by clinical challenge and that resolve without developing vasculitis. Nevertheless, in view of their known potential to activate complements, 20 mast cells, 21 and neutrophils, it is possible that these proteins may not act alone but in combination with other infiltrating cells and their granule proteins to initiate or take part in a cascade that leads to vessel damage.…”

Eosinophilic Vasculitis: Time for Recognition of a New Entity?

“…The clinical manifestations of HES are dependent on the organs affected. Vasculitis has been associated with the hypereosinophilic syndrome as a separate entity, distinct from that seen in EGPA [3]. Two forms of eosinophilic vasculitis have been described.…”

Annular skin lesions in childhood. Review of the main differential diagnoses

“…Another typical manifestations of that entity is the appearance of angioedema in the face, hands and feet. It can be confused with serum sickness disease, however in this case the individual lesions are fixed and there is no dermografism asociated [15,16].…”

“…It is a self-limiting rash with resolution of episodes in about 8-10 days, with good response to oral antihistamines, reserving the use of systemic corticosteroids for more severe cases [15].…”