Recurrence of venous leg ulceration

Reeder, S. W. I.; Eggen, C.A.M.; Maessen-Visch, M. B.; Roos, Kristian; Neumann, H. A. M.

doi:10.1016/j.rvm.2013.08.002

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…After healing, a VLU recurs within a year in about 20% of the patients. This percentage increases over time, and in some patients, the VLU recurs even more than once . A systematic review on compression hosiery to prevent recurrence showed that compression hosiery can be a protective factor in the recurrence of a VLU .…”

Section: Introductionmentioning

confidence: 99%

A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

Meulendijks

Vries

Dooren

et al. 2019

Acad Dermatol Venereol

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Venous Leg Ulcers (VLU) occur in about 1% of the Western population. A VLU takes 3–12 months to heal, it recurs often, and it has a negative impact on the quality of life. The risk factors for the development of a first VLU are not well‐understood and prevention of a first VLU therefore remains underappreciated. The aim of this study was to identify risk factors for developing a first VLU in adults (aged > 18 years) by searching the literature. We searched the Cochrane Library, Pubmed, Cinalh and Narcisto identify studies that investigated risk factors in developing a VLU. The last search was performed in January 2018. Two reviewers independently reviewed the abstracts and full‐text articles, and assessed the methodological quality of the included studies. Results of studies using duplex scanning, and comparing participants with and without VLUs were included in the qualitative analysis. Where possible a quantitative meta‐analysis was conducted. We found five studies that investigated the relation of several risk factors with VLU development. The methodological differences of the studies made it impossible to perform a quantitative analysis. The risk factors higher age (four studies), higher body mass index (four studies), low physical activity (four studies), arterial hypertension (four studies), deep vein reflux (three studies), deep venous thrombosis (three studies) and family history of VLU (three studies) were significantly associated with a VLU in the majority of the studies. To what extent they influence the development of a VLU remains unclear because of the limited number of studies that investigated the association of these risk factors with VLU development, and the heterogeneity of these studies. Further studies are needed to confirm the association of these risk factors with the development of a VLU and to explore overweight and low physical activity in more detail.

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Section: Introductionmentioning

confidence: 99%

A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

Meulendijks

Vries

Dooren

et al. 2019

Acad Dermatol Venereol

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“…It has been estimated that about 1% of the adult population has experienced venous leg ulceration (Fowkes, Evans, & Lee, 2001). Recurrence rates are high and reports in the literature inconsistent (Reeder, Eggen, Maessen-Visch, de Roos, & Martino Neumann, 2013). Venous leg ulcers can affect physical and psychological health, reduce quality of life (Gonz alez-Consuegra & Verd u, 2011;Green, Jester, McKinley, & Pooler, 2013) and are costly for the individual and the community.…”

Section: Introductionmentioning

confidence: 99%

Reflection on the cause and avoidance of recurrent venous leg ulcers: An interpretive descriptive approach

Stewart

Edwards

Finlayson

2018

Journal of Clinical Nursing

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“… 8 , 9 Moreover, in the case of VLUs, it has been reported that they recur in 70% of cases, and recent data demonstrate high VLU recurrence rates, ranging from 0% at 6 months to 56% at 54 months. 10 , 11 Therefore, new treatment options for chronic skin ulcers are needed. In this context, the use of low energy level light therapy that relies on the effect of photobiomodulation (PBM) is an attractive alternative therapy to enhance wound healing and a promising strategy for the management of complex chronic wounds.…”

Section: Introductionmentioning

confidence: 99%

EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis

Romanelli

Piaggesi

Scapagnini

et al. 2017

DDDT

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ObjectiveInterest has grown regarding photobiomodulation (PBM) with low-level light therapy, which has been shown to positively affect the stages of the wound healing process. In a real-life context clinical setting, the objective of the EUREKA study was to investigate efficacy, safety, and quality of life associated with the use of a BioPhotonic gel (LumiHeal™) in the treatment of chronic wounds such as venous leg ulcers (VLUs), diabetic foot ulcers (DFUs), and pressure ulcers (PUs). This BioPhotonic gel represents a new, first-in-class emission spectrum of light, including fluorescence, to induce PBM and modulate healing.DesignThe multicenter, prospective, interventional, uncontrolled, open-label study enrolled 100 patients in 12 wound centers in Italy. We performed an early interim analysis based on the first 33 subjects (13 VLU, 17 DFU, 3 PU) in seven centers who completed the study.Main resultsSeventeen patients (52%) achieved total wound closure (full re-epithelialization for 2 weeks) during the study period. Two patients (6%) were considered “almost closed” (decrease of the wound area of more than 90% at study end) and three others (9%) were considered “ready for skin grafting”. No related serious adverse events were observed, and the compliance was excellent. After the treatment, the average time to “pain-free” was 11.9 days in the VLU group. Quality of life was improved with overall increase of 26.4% of the total score (Cardiff Wound Impact Schedule, p=0.001).ConclusionThe study revealed a positive efficacy profile of the BioPhotonic gel in promoting wound healing and reactivating the healing process in different types of chronic, hard-to-heal wounds. The treatment was shown to be safe and well tolerated by the patients, and a reduction of pain perception was also detected during the treatment period. The improvement of the quality of life was accompanied by a high level of clinician satisfaction.

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Recurrence of venous leg ulceration

Cited by 7 publications

References 30 publications

A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

Reflection on the cause and avoidance of recurrent venous leg ulcers: An interpretive descriptive approach

EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis

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Recurrence of venous leg ulceration

Cited by 7 publications

References 30 publications

A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

Reflection on the cause and avoidance of recurrent venous leg ulcers: An interpretive descriptive approach

EUREKA study &ndash; the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis

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EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis