Recurrence after Total Thyroidectomy for Benign Multinodular Goiter

Snook, Kylie; Stålberg, Peter; Sidhu, Stan; Sywak, Mark; Edhouse, Pamela; Delbridge, Leigh

doi:10.1007/s00268-006-0135-0

Cited by 58 publications

(66 citation statements)

References 42 publications

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“…6 During the 1980s-1990s there were authors who favored an ST in the treatment of benign diseases due to the proposed lower incidence of surgical complications and supposed postoperative euthyroid state, 7-9 while others advocated the use of a TT because of a similar complication rate to the subtotal procedure and proposed lower pathologic recurrence rate. [10][11][12] Our previous study on the subject also supports the TT choice.…”

Section: Discussionmentioning

confidence: 99%

Complications in primary and completed thyroidectomy

2010

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Section: Discussionmentioning

confidence: 99%

Complications in primary and completed thyroidectomy

2010

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“…Total thyroidectomy is the operation of choice for multinodular goiter for the majority of endocrine surgeons (Hisham et al 2001, Snook et al 2007). Thus, total thyroidectomy is recommended for a suspicious nodule in multinodular goiter.…”

Section: Discussionmentioning

confidence: 99%

Combined analysis of galectin-3 and BRAFV600E improves the accuracy of fine-needle aspiration biopsy with cytological findings suspicious for papillary thyroid carcinoma

Sapio¹,

Guerra²,

Posca³

et al. 2007

Endocrine Related Cancer

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Ten to fifteen percent of fine-needle aspiration biopsy (FNAB) of thyroid nodules are indeterminate. Galectin-3 (Gal-3) and the oncogene BRAF V600E are markers of malignancy useful to improve FNAB accuracy. The objective of this study was to determine whether the combined analysis of Gal-3 and BRAF V600E expression in thyroid aspirates could improve the diagnosis in FNAB with suspicious cytological findings. Two hundred and sixty-one surgical thyroid tissues and one hundred and forty-four thyroid aspirates were analyzed for the presence of the two markers. In surgical specimens, Gal-3 expression was present in 27.4% benign nodules, 91.9% papillary (PTC) and 75% follicular (FTC) thyroid carcinomas. BRAF V600E was not detected in 127 benign nodules, as well as in 32 FTCs, while was found in 42.9% PTC. No correlation was found between BRAF mutation and Gal-3 expression. Forty-seven consecutive FNAB suspicious for PTC were analyzed for the presence of the two markers. Of these nodules, 23 were benign at histology, 6 were positive for Gal-3, none displayed BRAF V600E, and 17 were negative for both the markers. Twenty suspicious nodules were diagnosed as PTC and four FTCs at histology. Of these 24 carcinomas, 9 resulted positive for BRAF V600E, 17 for Gal-3, and 22 for one or both the markers. The sensitivity, specificity, and accuracy for the presence of Gal-3 and/or BRAF V600E were significantly higher than those obtained for the two markers alone. Notably, the negative predictive value increased from 70.8 to 89.5%. In conclusion, the combined detection of Gal-3 and BRAF V600E improves the diagnosis in FNAB with cytological findings suspicious for PTC and finds clinical application in selected cases.

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“…Vaiman et al described a recurrence rate of over 20% for benign thyroid diseases after subtotal thyroidectomy [23]. Other studies, too, have demonstrated that total thyroidectomy for multinodular goitre is a safe as well as an effective procedure in preventing goitre recurrence [24,25] and, due to a higher rate of complications after surgery for recurrent goitre, total thyroidectomy for multinodular goitre is advisable [26].…”

Section: Discussionmentioning

confidence: 95%