Rectal Cancer: Assessment of Complete Response to Preoperative Combined Radiation Therapy with Chemotherapy—Conventional MR Volumetry versus Diffusion-weighted MR Imaging

Abstract

Post-CRT DW MR volumetry provided high diagnostic performance in assessing CR and was significantly more accurate than T2-weighted MR volumetry. Post-CRT DW MR was equally as accurate as volume measurements of both T2-weighted and DW MR. Pre-CRT volumetry and ADC were not reliable.

Test-Retest and Interreader Reproducibility of Semiautomated Atlas-Based Analysis of Diffusion Tensor Imaging Data in Acute Cervical Spine Trauma in Adult Patients

“…Qualitative interpretation of ICC values are as follows: 0 -.20 ϭ poor; 0.21-0.40 ϭ fair; 0.41-0.60 ϭ moderate; 0.61-0.80 ϭ good; and 0.81-1 ϭ excellent. 8 For test-retest reproducibility, these metrics were calculated separately for each reader, and then the metrics from the readers were averaged. Similarly, for interreader reproducibility, these metrics were calculated separately for each acquisition, and then the metrics from the acquisitions were averaged.…”

“…1 In various disease states, DTI has been extensively investigated in brain applications and can detect abnormalities in otherwise normal-appearing brain regions 2,3 and is able to predict outcomes. 4 Early DTI use shows promise in detecting spinal cord abnormalities associated with spinal cord injury, 5,6 demyelinating diseases, 7 spondylotic myelopathy, 8 HIV myelopathy, 9 and various inflammatory and vascular myelopathies. 10 In acute spinal cord trauma, DTI has shown value in assessing microstructural injury, differentiating between hemorrhagic and nonhemorrhagic contusions, and strong correlation with clinical injury scores.…”

Role of diffusion-weighted imaging for detecting bone marrow infiltration in skull in children with acute lymphoblastic leukemia

“…The inter-reader agreement of ADC was evaluated with interclass correlation coefficients (ICC). ICC interclass correlation coefficient is interpreted as follows: 0.61-0.80, good agreement; 0.81-1.00, excellent agreement (10). The level of significance was set at P < 0.05.…”

Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer

“…The apparent diffusion coefficient (ADC) calculated from DW-MRI measurements may be used to quantify and express these properties. The majority of the studies have demonstrated that the pretreatment ADC is negatively correlated with response to treatment (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). It appears that necrotic areas with high pretreatment ADC values may be less sensitive to CRT.…”