Recruitment of attentional resources during visuomotor tracking: effects of Parkinson's disease and age

Hocherman, Shraga; Moont, Ruth; Schwartz, Miguel

doi:10.1016/j.cogbrainres.2004.05.008

Cited by 13 publications

(13 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The quality of tracking in PD has been shown to be largely influenced by cognitive-executive dysfunction, whereby the frequency of tracking interruptions is much higher in PD patients than in normal controls [75]. The present study shows no improvement in the frequency of tracking interruptions with DBS suggesting that this therapy does not affect the patient’s executive function.…”

Section: Discussioncontrasting

confidence: 65%

Subthalamic Nucleus Deep Brain Stimulation Does Not Improve Visuo-Motor Impairment in Parkinson’s Disease

et al. 2013

Self Cite

View full text Add to dashboard Cite

ObjectiveTo evaluate how bilateral subthalamic nucleus deep brain stimulation (STN-DBS) affects visuo-motor coordination (VMC) in patients with Parkinson’s disease (PD).BackgroundVMC involves multi-sensory integration, motor planning, executive function and attention. VMC deficits are well-described in PD. STN-DBS conveys marked motor benefit in PD, but pyscho-cognitive complications are recognized and the effect on VMC is not known.MethodsThirteen PD patients with bilateral STN-DBS underwent neurological, cognitive, and mood assessment before VMC testing with optimal DBS stimulation parameters (‘on-stimulation’) and then, on the same day without any medication changes, after DBS silencing and establishing motor function deterioration (‘off-stimulation’). Twelve age-matched healthy controls performed 2 successive VMC testing sessions, with a break of similar duration to that of the PD group. The computer cursor was controlled with a dome-shaped ‘mouse’ hidden from view that minimized tremor effects. Movement duration, hand velocity, tracking continuity, directional control variables, and feedback utilization variables were measured. MANOVA was performed on (1) clinically measured motor function, (2) VMC performance and (3) mood and attention, looking for main and interaction effects of: (1) group (controls/PD), (2) test-order (controls: first/second, PD: on-stimulation/off-stimulation), (3) path (sine/square/circle) and (4) hand (dominant/non-dominant).ResultsUnified PD Rating Scale (UPDRS) Part III worsened off-stimulation versus on-stimulation (mean: 42.3 versus 21.6, p = 0.02), as did finger tapping (p = 0.02), posture-gait (p = 0.01), upper limb function (p<0.001) and backwards digit span (p = 0.02). Stimulation state did not affect mood. PD patients performed worse in non-velocity related VMC variables than controls (F(5,18) = 8.5, p<0.001). In the control group there were significant main effects of hand (dominant/non-dominant), path (sine/square/circle) and test-order (Test_1/Test_2). In the PD group, hand and path effects, but no test-order (on-stimulation/off-stimulation), were found.Conclusions‘Low-level’ clinically-measured motor function responds to STN-DBS but ‘high-level’ motor and cognitive functions relating to VMC may be unresponsive to STN-DBS.

show abstract

Section: Discussioncontrasting

confidence: 65%

Subthalamic Nucleus Deep Brain Stimulation Does Not Improve Visuo-Motor Impairment in Parkinson’s Disease

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…As explained above, different measures of VMC pertain to different functional domains. Most importantly, the frequency of tracking interruptions relates most strongly to cognitive executive functionality which underlies the ability to persist in tracking [10] , [25] , while the directional error in tracing relates most strongly to production of appropriate visuo-motor transformations [24] . Whether these variables are correlated determines how their relationships to the UPDRS item groups can be interpreted.…”

Section: Resultsmentioning

confidence: 99%

“…As shown before, the quality of tracking is influenced mainly by a cognitive-executive disability that can be linked to frontal cortical dysfunction in PD [25]. In addition, the basal ganglia (BG) are known to exert direct control over the pedunculo-pontine nuclei and through this pathway be involved in the selection of appropriate context relevant actions, pertaining to the coordination of gait [27].…”

Section: Discussionmentioning

confidence: 97%

“…Within this framework the BG are believed to be involved in on/off switching of different gait components in a way that ensures matching of the overall behavioral outcome to the organism's intention [27]. This role is very similar to the organizing role which must be played during tracking [3], [6], [10], [24], [25], as tracking itself consists of performing a series of small movement segments. If the BG mechanism that is involved in organizing the sequence of actions during normal stepping is faulty, it would be plausible to extrapolate that other sequencing-dependent actions, such as tracking, would be impaired.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Visuo-Motor Coordination Deficits and Motor Impairments in Parkinson's Disease

2008

Self Cite

View full text Add to dashboard Cite

BackgroundVisuo-motor coordination (VMC) requires normal cognitive executive functionality, an ability to transform visual inputs into movement plans and motor-execution skills, all of which are known to be impaired in Parkinson's disease (PD). Not surprisingly, a VMC deficit in PD is well documented. Still, it is not known how this deficit relates to motor symptoms that are assessed routinely in the neurological clinic. Such relationship should reveal how particular motor dysfunctions combine with cognitive and sensory–motor impairments to produce a complex behavioral disability.Methods and FindingsThirty nine early/moderate PD patients were routinely evaluated, including motor Unified Parkinson's Disease Rating Scale (UPDRS) based assessment, A VMC testing battery in which the subjects had to track a target moving on screen along 3 different paths, and to freely trace these paths followed. Detailed kinematic analysis of tracking/tracing performance was done. Statistical analysis of the correlations between measures depicting various aspects of VMC control and UPDRS items was performed. The VMC measures which correlated most strongly with clinical symptoms represent the ability to organize tracking movements and program their direction, rather than measures representing motor-execution skills of the hand. The strong correlations of these VMC measures with total UPDRS score were weakened when the UPDRS hand-motor part was considered specifically, and were insignificant in relation to tremor of the hand. In contrast, all correlations of VMC measures with the gait/posture part of the UPDRS were found to be strongest.ConclusionsOur apparently counterintuitive findings suggest that the VMC deficit pertains more strongly to a PD related change in cognitive-executive control, than to a reduction in motor capabilities. The recently demonstrated relationship between gait/posture impairment and a cognitive decline, as found in PD, concords with this suggestion and may explain the strong correlation between VMC dysfunction and gait/posture impairment. Accordingly, we propose that what appears to reflect a motor deficit in fact represents a multisystem failure, dominated by a cognitive decline.

show abstract

“…Another issue concerns visuomotor tracking approach for understanding the contribution of motor control to walking, Visuomotor tracking provides a simple approach for tapping into neuromuscular system's ability to integrate and modulate motor output for performing functional mobility tasks. Specifically, the visuomotor tracking involves three functional domains (a) attentional resources (70, 71), (b) visual processing to transform the information about target position into movement planning (72), and (c) motor ability to produce steady and accurate movements (8, 73). Similarly, walking requires the complex integration of cognitive, visual, and motor functions (74, 75).…”

Section: Discussionmentioning

confidence: 99%

Strength or Motor Control: What Matters in High-Functioning Stroke?

et al. 2019

View full text Add to dashboard Cite

Background: The two primary motor impairments that hinder function after stroke are declines in strength and motor control. The impact of motor impairments on functional capacity may vary with the severity of stroke motor impairments. In this study, we focus on high-functioning stroke individuals who experience mild to moderate motor impairments and often resume prior activities or return to work. These tasks require the ability to move independently, placing high demands on their functional mobility. Therefore, the purpose of this study was to quantify impairments in strength and motor control and their contribution to functional mobility in high-functioning stroke.Methods:Twenty-one high-functioning stroke individuals (Fugl Meyer Lower Extremity Score = 28.67 ± 4.85; Functional Activity Index = 28.47 ± 7.04) and 21 age-matched healthy controls participated in this study. To examine motor impairments in strength and motor control, participants performed the following tasks with the paretic ankle (1) maximum voluntary contractions (MVC) and (2) visuomotor tracking of a sinusoidal trajectory. Strength was quantified as the maximum force produced during ankle plantarflexion and dorsiflexion. Motor control was quantified as (a) the accuracy and (b) variability of ankle movement during the visuomotor tracking task. For functional mobility, participants performed (1) overground walking for 7 meters and (2) simulated driving task. Functional mobility was determined by walking speed, stride length variability, and braking reaction time.Results: Compared with the controls, the stroke group showed decreased plantarflexion strength, decreased accuracy, and increased variability of ankle movement. In addition, the stroke group demonstrated decreased walking speed, increased stride length variability, and increased braking reaction time. The multiple-linear regression model revealed that motor accuracy was a significant predictor of the walking speed and braking reaction time. Further, motor variability was a significant predictor of stride length variability. Finally, the dorsiflexion or plantarflexion strength did not predict walking speed, stride length variability or braking reaction time.Conclusions: The impairments in motor control but not strength predict functional deficits in walking and driving in high-functioning stroke individuals. Therefore, rehabilitation interventions assessing and improving motor control will potentially enhance functional outcomes in high-functioning stroke survivors.

show abstract

Recruitment of attentional resources during visuomotor tracking: effects of Parkinson's disease and age

Cited by 13 publications

References 31 publications

Subthalamic Nucleus Deep Brain Stimulation Does Not Improve Visuo-Motor Impairment in Parkinson’s Disease

Subthalamic Nucleus Deep Brain Stimulation Does Not Improve Visuo-Motor Impairment in Parkinson’s Disease

Visuo-Motor Coordination Deficits and Motor Impairments in Parkinson's Disease

Strength or Motor Control: What Matters in High-Functioning Stroke?

Contact Info

Product

Resources

About