Abstract:136 Background: Chemotherapy-induced left ventricular dysfunction (CILVD) leading to heart failure (HF) is a clinical problem of emerging importance particularly with the 14.5 million cancer survivors who are alive in the United States today, and projected to increase to almost 19 million in 2024. Many of these survivors have received cardiotoxic anticancer agents such as anthracycline and trastuzumab. Research showed that those exposed to anthracyclines are expected to have some degree of cardiac dysfunction… Show more
“…For example, the CDC reports that almost one third of all American adults have been diagnosed with hypertension (8). If a patient with a long history of hypertension now presents with breast cancer and cannot tolerate her neoadjuvant chemotherapy due to the previous damage her heart has sustained that will have a negative consequence on the treatment plan overall (9,10). Without that critical reduction in tumor burden the surgery may have to be drastically altered and could result in far greater morbidity and decreased survival.…”
“…For example, the CDC reports that almost one third of all American adults have been diagnosed with hypertension (8). If a patient with a long history of hypertension now presents with breast cancer and cannot tolerate her neoadjuvant chemotherapy due to the previous damage her heart has sustained that will have a negative consequence on the treatment plan overall (9,10). Without that critical reduction in tumor burden the surgery may have to be drastically altered and could result in far greater morbidity and decreased survival.…”
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