2009
DOI: 10.1016/s0828-282x(09)70497-0
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Abstract: LV dysfunction recurs in some patients with reversible IDCMP. The recurrence was significantly correlated with the discontinuation of antiheart failure drugs. The results suggest that continuous medical therapy may be mandatory in patients who recover from LV systolic dysfunction.

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Cited by 59 publications
(39 citation statements)
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“…In contrast, HFm-recEF showed similar prognosis as HFpEF, indicating that HF with mid-range LVEF and recovered systolic function still carries a significant risk of adverse outcomes. These latter findings are clinically relevant because they provide additional basis for maintaining subjects with recovered LVEF on background medical and device therapy, as previously recommended (8, 9, 16). The differences in prognosis between HFmEF and HFm-recEF may also help explain some reported discrepancies regarding prognosis in the mid-range LVEF HF population.…”
Section: Discussionsupporting
confidence: 53%
“…In contrast, HFm-recEF showed similar prognosis as HFpEF, indicating that HF with mid-range LVEF and recovered systolic function still carries a significant risk of adverse outcomes. These latter findings are clinically relevant because they provide additional basis for maintaining subjects with recovered LVEF on background medical and device therapy, as previously recommended (8, 9, 16). The differences in prognosis between HFmEF and HFm-recEF may also help explain some reported discrepancies regarding prognosis in the mid-range LVEF HF population.…”
Section: Discussionsupporting
confidence: 53%
“…This recommendation is consistent with prior reports suggesting cessation of medical therapy was associated with a recurrence of LV dysfunction in patients who had previously improved or “recovered” their EF. 8, 24 In fact, we note that the majority of patients in our HF-recovered group remained on medical therapy despite normalization of LV function. This is consistent with the idea that a recovery of ejection fraction does not necessarily constitute recovery from heart failure.…”
Section: Discussionmentioning
confidence: 72%
“…36 "Recovery" may also reflect the effects of pharmacotherapy. A recent study 31 in children with IDCM who recovered LV function demonstrated recurrence of LV dysfunction when drug therapy was withdrawn.…”
Section: Discussionmentioning
confidence: 98%