“…SLC19 is a folate/thiamine transporter family, and there are three members (SLC19A1-3), of which SLC19A1 transports folates but not thiamine, and the other two transport thiamine but not folates (Zhao and Goldman, 2013). Mutations in the SLC19A2 gene, encoding thiamine transporter 1 (THTR1), were reported to be associated with thiamine-responsive megaloblastic anemia (TRMA) (Scharfe et al, 2000;Ozdemir et al, 2002;Ghaemi et al, 2013;Setoodeh et al, 2013;Sun et al, 2018;Amr et al, 2019), which is characterized by early-onset diabetes mellitus, anemia, and sensorineural deafness.…”