Reconstruction of Canine Mandibular Bone Defects Using a Bone Transport Reconstruction Plate

Elsalanty, Mohammed; Zakhary, Ibrahim; Akeel, Sara; Benson, Byron W.; Mulone, Timothy; Triplett, Gilbert R.; Opperman, Lynne A.

doi:10.1097/sap.0b013e31818d130c

Cited by 25 publications

(39 citation statements)

References 53 publications

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“…Several MBT devices based on power screw activation are unable to reproduce the curvature of the mandible, because they produce unidirectional distraction by moving the transport unit parallel to the screw (Table 1). 1,9,15,[18][19][20][21]23,42,45 It is possible to improve their design to generate bidirectional MBT by adding complementary moveable mechanisms 31 performing complementary steps that include the rotation of the distraction device 57 or bending either the track 8,30 or the screw.…”

Section: 49mentioning

confidence: 99%

“…26,30,54 A novel MBT device, which combines the power screw activation mechanism with the stabilizing reconstruction plate to form a bone transport reconstruction plate unit, has recently been developed. 42 Combining the MBT and reconstruction plate reduces the size of the internal device and increases the stability of the transport unit. Curving the reconstruction=bone transport plate will allow this device to conduct monofocal bone transport across the mandibular midline or bifocal bone transport to meet at the midline (Fig.…”

Section: 26mentioning

confidence: 99%

“…5): power screw, 1,8,9,15,[17][18][19][20][21][22][23]26,[28][29][30][31][32]42,45,54 spring, 24,25,55 traction wire, 14,16 hydraulic, 27 and rack and pinion. 2,56 The power screw activation system, also called screw lead activation system, translates torque into linear force to be used to distract the mandibular bone by matching an external helical threaded screw with either a negative or female threaded nut with the same thread form (Fig.…”

Section: 49mentioning

confidence: 99%

“…The relationship with the cutaneous tissues MBT devices can be internal, 9,[14][15][16][17][18][19][20][21]24,25,27,31,42 if the bulk of the device is buried beneath the cutaneous tissues, or external, 1,8,22,23,26,[28][29][30]32,[43][44][45] if the device uses transcutaneous pins to attach to the bone (Fig. 4).…”

Section: The Anchoring Tissuementioning

confidence: 99%

“…However, it is also possible to achieve MBT without guide bars, by using devices complemented with a titanium reconstruction plate. 1,15,[18][19][20]22,26,29,42,45 Most of the power screw activation systems without guide bars are built to accomplish monofocal distraction on the mandible. 13,62,63 Power screw activation systems with one and two complementary guides are mechanically more stable than power screw activation systems without guides or supporting reconstruction plates.…”

Section: 26mentioning

confidence: 99%

See 4 more Smart Citations

Biomechanical Configurations of Mandibular Transport Distraction Osteogenesis Devices

Zapata

Elsalanty

Dechow³

et al. 2010

Tissue Engineering Part B: Reviews

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Section: 49mentioning

confidence: 99%

Section: 26mentioning

confidence: 99%

Section: 49mentioning

confidence: 99%

Section: The Anchoring Tissuementioning

confidence: 99%

Section: 26mentioning

confidence: 99%

See 3 more Smart Citations

Biomechanical Configurations of Mandibular Transport Distraction Osteogenesis Devices

Zapata

Elsalanty

Dechow³

et al. 2010

Tissue Engineering Part B: Reviews

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Defining the Critical-Sized Defect in a Rat Segmental Mandibulectomy Model

DeConde

Lee

Sidell

et al. 2014

JAMA Otolaryngol Head Neck Surg

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Importance Advances in tissue engineering offer potential alternatives to current mandibular reconstructive techniques; however, prior to clinical translation of this technology, a relevant animal model must be used to validate possible interventions. Objective This study aims to establish the critical-sized segmental mandibular defect that does not heal spontaneously in the rat mandible. Design Prospective study using an animal model. Setting Animal laboratory. Participants Sprague-Dawley rats. Interventions Twenty-nine Sprague-Dawley rats underwent creation of one of four segmental mandibular defects: 0-mm, 1-mm, 3-mm and 5-mm. All mandibular wounds were internally fixated with 1-mm microplates and screws and allowed to heal for 12-weeks. Main Outcomes and Measures Mandibles were analyzed with micro-computed tomography (microCT) and bony healing was graded on a semi-quantitative scale. Results Seven animals were utilized in each experimental group. No 5-mm segmental defects successfully developed bony union, whereas all 0-mm and 1-mm defects had continuous bony growth across the original defect on micro-CT. Three of the 3-mm defects had bony continuity, and three had no healing of the bony wound. Bony union scores were significantly lower in the 5-mm defects compared to 0-mm, 1-mm and 3-mm defects (all p < 0.01). Conclusion and Relevance The rat segmental mandible model cannot heal a 5-mm segmental mandibular defect. Successful healing of 0-, 1- and 3-mm defects confirms adequate stabilization of bony wounds with internal fixation with 1-mm microplates. The rat segmental mandibular critical-sized defect provides a clinically relevant testing ground for translatable mandibular tissue engineering efforts.

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Three-Dimensional Evaluation of Mandibular Bone Regenerated By Bone Transport Distraction Osteogenesis

et al. 2011

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The purpose of this study was to evaluate the structure and material properties of native mandibular bone and those of early regenerate bone, produced by bone transport distraction osteogenesis. Ten adult foxhounds were divided into two groups of five animals each. In all animals, a 3- to 4-cm defect was created on one side of the mandible. A bone transport reconstruction plate, consisting of a reconstruction plate with an attached intraoral transport unit, was utilized to stabilize the mandible and regenerate bone at a rate of 1 mm/day. After the distraction period was finished, the animals were killed at 6 and 12 weeks of consolidation. Micro-computed tomography was used to assess the morphometric and structural indices of regenerate bone and matching bone from the unoperated contralateral side. Significant new bone was formed within the defect in the 6- and 12-week groups. Significant differences (P ≤ 0.05) between mandibular regenerated and native bone were found in regard to bone volume fraction, mineral density, bone surface ratio, trabecular thickness, trabecular separation, and connectivity density, which increased from 12 to 18 weeks of consolidation. We showed that regenerated bone is still mineralizing and that native bone appears denser because of a thick outer layer of cortical bone that is not yet formed in the regenerate. However, the regenerate showed a significantly higher number of thicker trabeculae.

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Reconstruction of Canine Mandibular Bone Defects Using a Bone Transport Reconstruction Plate

Cited by 25 publications

References 53 publications

Biomechanical Configurations of Mandibular Transport Distraction Osteogenesis Devices

Biomechanical Configurations of Mandibular Transport Distraction Osteogenesis Devices

Defining the Critical-Sized Defect in a Rat Segmental Mandibulectomy Model

Three-Dimensional Evaluation of Mandibular Bone Regenerated By Bone Transport Distraction Osteogenesis

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