Reconstruction and Visualization of Fiber and Laminar Structure in the Normal Human Heart from Ex Vivo Diffusion Tensor Magnetic Resonance Imaging (DTMRI) Data

Rohmer, Damien; Sitek, Arkadiusz; Gullberg, Grant T.

doi:10.1097/rli.0b013e3181238330

Cited by 144 publications

(152 citation statements)

References 40 publications

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“…The availability of a full 3D atlas of the cardiac architecture opens the door to not only the construction of more accurate extrapolation models for in vivo acquisitions, but also to a better understanding of various cardiac mechanical functions, cardiac electrophysiology patterns, and remodeling processes. So far only ex vivo canine DT-MRI studies [9,13] have been considered, and in humans, only cases using a single ex vivo heart has been studied [15] and visualized in 3D [16]. Histological and DT-MRI studies all lead to similar findings.…”

Section: Introductionmentioning

confidence: 51%

Statistical Analysis of the Human Cardiac Fiber Architecture from DT-MRI

Lombaert

Peyrat

Croisille

et al. 2011

Functional Imaging and Modeling of the Heart

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Abstract. A statistical atlas of the cardiac fiber architecture is built for the first time with a human dataset of 10 healthy ex vivo hearts acquired using DT-MRI. The atlas is constructed using an efficient semi-automated method where limited interactions are only required to segment the myocardium. All hearts are registered automatically by an efficient and robust non linear registration method. The statistical atlas gives a better understanding of the human cardiac fiber architecture. The study on the global variability of the human cardiac fiber architecture reveals that the fiber orientation is more stable than the laminar sheet orientation. The variability is also consistent across the left ventricular AHA segments. Moreover this atlas could be used for cardiac electromechanical modeling as well as a basis for more precise extrapolation models, essential for in vivo cardiac DT-MRI acquisition.

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Section: Introductionmentioning

confidence: 51%

Statistical Analysis of the Human Cardiac Fiber Architecture from DT-MRI

Lombaert

Peyrat

Croisille

et al. 2011

Functional Imaging and Modeling of the Heart

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“…The overall scheme of left-handed helical patterns in the epicardial regions of the left ventricular walls, and reciprocal right-handed helical patterns in the endocardial regions, have been known since the stellar study of Pettigrew (Pettigrew, 1864). This architectural outline was revived by Streeter using histology (Streeter et al, 1966;Streeter et al, 1969), and has recently been fully consolidated using the technique of diffusion tensor magnetic resonance imaging (Helm et al, 2005;Rohmer et al, 2007). Using this novel, but validated, technique (Hsu et al, 1998;Scollan et al, 1998), we have now demonstrated that in keeping with the demonstration of myocytes also aggregated in transmural fashion (Lunkenheimer et al, 2006), reproducible pathways can be demonstrated within the walls using diffusion tensor magnetic resonance imaging (Smerup et al, 2008).…”

mentioning

confidence: 99%

Normal Right Ventricular Three‐Dimensional Architecture, as Assessed with Diffusion Tensor Magnetic Resonance Imaging, is Preserved During Experimentally Induced Right Ventricular Hypertrophy

Nielsen

Smerup

Agger

et al. 2009

The Anatomical Record

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The three-dimensional architecture of the right ventricular myocardium is a major determinant of function, but as yet no investigator-independent methods have been used to characterize either the normal or hypertrophied state. We aimed to assess and compare, using diffusion tensor magnetic resonance imaging, the normal architecture with the arrangement induced by chronic hypertrophy. We randomized 20 female 5 kg piglets into pulmonary trunk banding (N ¼ 16) and sham operation (N ¼ 4). Right ventricular hypertrophy was assessed after 8 weeks. The excised and fixed hearts were subject to diffusion tensor imaging to determine myocyte helical angles, and the presence of any reproducible tracks formed by the aggregated myocytes. All banding animals developed significant right ventricular hypertrophy, albeit that no difference was observed in terms of helical angles or myocardial pathways between the banded animals and sham group animals. Helical angles varied from $70 degrees endocardially to À50 degrees epicardially. Very few tracks were circular, with helical angles approximating zero. Reproducible patterns of chains of aggregated myocytes were observed in all hearts, regardless of group. The architecture of the myocytes aggregated in the walls of the right ventricle is comparable to that found in the left ventricle in terms of endocardial and epicardial helical angles, however the right ventricle both in the normal and the hypertrophied state lacks the extensive zone of circular myocytes seen in the mid-portion of the left ventricular walls. Without such beneficial architectural remodelling, the porcine right ven-*Correspondence to:

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“…These studies demonstrate salient and consistent local and global patterns in mammalian cardiac fiber architecture. These patterns are supported by histological measurements [1] and include [6] an inner to outer wall turning of the cardiac fibers in a smooth and regular fashion undergoing a total change of about 110…”

Section: Introductionmentioning

confidence: 68%

“…Diffusion Tensor Imaging (DTI) of ex-vivo hearts has been studied extensively across many species, including the human [1], dog [2], goat [3], rat [4] and the pig [5]. These studies demonstrate salient and consistent local and global patterns in mammalian cardiac fiber architecture.…”

Section: Introductionmentioning

confidence: 99%

“…It is well accepted that in the heart wall the principal direction of diffusion correlates strongly with the underlying cardiac fiber direction [1], and that it varies smoothly in the neighborhood of a voxel, but there is much greater variability in the directions of the second and third eigenvectors. For these reasons we choose to work directly with the principal eigenvector of the diffusion tensor.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac Fiber Inpainting Using Cartan Forms

Piuze

Lombaert

Sporring

et al. 2013

Advanced Information Systems Engineering

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Abstract. Recent progress in diffusion imaging has lead to in-vivo acquisitions of fiber orientation data in the beating heart. Current methods are however limited in resolution to a few short-axis slices. For this particular application and others where the diffusion volume is subsampled, partial or even damaged, the reconstruction of a complete volume can be challenging. To address this problem, we present two complementary methods for fiber reconstruction from sparse orientation measurements, both of which derive from second-order properties related to fiber curvature as described by Maurer-Cartan connection forms. The first is an extrinsic partial volume reconstruction method based on principal component analysis of the connection forms and is best put to use when dealing with highly damaged or sparse data. The second is an intrinsic method based on curvilinear interpolation of the connection forms on ellipsoidal shells and is advantageous when more slice data becomes available. Using a database of 8 cardiac rat diffusion tensor images we demonstrate that both methods are able to reconstruct complete volumes to good accuracy and lead to low reconstruction errors.

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Reconstruction and Visualization of Fiber and Laminar Structure in the Normal Human Heart from Ex Vivo Diffusion Tensor Magnetic Resonance Imaging (DTMRI) Data

Abstract: A visualization algorithm was developed to demonstrate the complex 3-dimensional orientation of the fibers and sheets in human myocardium.

Cited by 144 publications

References 40 publications

Statistical Analysis of the Human Cardiac Fiber Architecture from DT-MRI

Statistical Analysis of the Human Cardiac Fiber Architecture from DT-MRI

Normal Right Ventricular Three‐Dimensional Architecture, as Assessed with Diffusion Tensor Magnetic Resonance Imaging, is Preserved During Experimentally Induced Right Ventricular Hypertrophy

Cardiac Fiber Inpainting Using Cartan Forms

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