Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07_BC and CRF08_BC in East Asia: The relevance of genetic diversity and phylodynamics for vaccine strategies

Takebe, Yutaka; Liao, Huanan; Hase, Saiki; Uenishi, Rie; Li, Yue; Li, Xiaojie; Han, Xiaoxu; Shang, Hong; Kamarulzaman, Adeeba; Yamamoto, Naoki; Pybus, Oliver G.; Tee, Kok Keng

doi:10.1016/j.vaccine.2009.07.101

Cited by 48 publications

(49 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subtype C from India and subtype B from Thailand caused the first outbreaks among PWID in Yunnan in the late 1980s and early 1990s (Han et al, 2015; Piyasirisilp et al, 2000; Tee et al, 2008; Zheng et al, 1994). Subtype B', that soon became the predominant B clade in China (Graf et al, 1998; Lau et al, 2007), and subtype C recombined to generate two related but distinct strains, CRF07_BC and CRF08_BC, which trace their origin to Yunnan and fueled the epidemic among PWID in Northwestern, Southeastern and Northeastern China, and to Taiwan (CRF07_BC) (Han et al, 2015; He et al, 2012; Laeyendecker et al, 2005; Lau et al, 2007; Li et al, 2015; Lin et al, 2006; Piyasirisilp et al, 2000; Takebe et al, 2010; Tee et al, 2008). CRF07_BC has also become the predominant strain among PWID (>80%) in Taiwan (Chen et al, 2012, 2010; Huang et al, 2014; Lin et al, 2006).…”

Section: Molecular Epidemiology Of Hiv Among Pwid In Asiamentioning

confidence: 99%

Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia

Nikolopoulos

Kostaki

Paraskevis

2016

Infection, Genetics and Evolution

View full text Add to dashboard Cite

HIV strains continuously evolve, tend to recombine and new circulating variants are being discovered. Novel strains complicate efforts to develop a vaccine against HIV and may exhibit higher transmission efficiency and virulence, and elevated resistance to antiretroviral agents. The United Nations Joint Programme on HIV/AIDS (UNAIDS) set an ambitious goal to end HIV as a public health threat by 2030 through comprehensive strategies that include epidemiological input as the first step of the process. In this context, molecular epidemiology becomes invaluable as it captures trends in HIV evolution rates that shape epidemiological pictures across several geographical areas. This review briefly summarizes the molecular epidemiology of HIV among people who inject drugs (PWID) in Europe and Asia. Following high transmission rates of subtype G and CRF14_BG among PWID in Portugal and Spain, two European countries, Greece and Romania, experienced recent HIV outbreaks in PWID that consisted of multiple transmission clusters including subtypes B, A, F1 and recombinants CRF14_BG and CRF35_AD. The latter was first identified in Afghanistan. Russia, Ukraine and other Former Soviet Union (FSU) states are still facing the devastating effects of epidemics in PWID produced by AFSU (also known as IDU-A), BFSU (known as IDU-B), and CRF03_AB. In Asia, CRF01_AE and subtype B (Western B and Thai B) travelled from PWID in Thailand to neighboring countries. Recombination hotspots in South China, Northern Myanmar, and Malaysia have been generating several intersubtype and inter-CRF recombinants (e.g. CRF07_BC, CRF08_BC, CRF33_01B etc.) increasing the complexity of HIV molecular patterns.

show abstract

Section: Molecular Epidemiology Of Hiv Among Pwid In Asiamentioning

confidence: 99%

Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia

Nikolopoulos

Kostaki

Paraskevis

2016

Infection, Genetics and Evolution

View full text Add to dashboard Cite

show abstract

“…Thereafter it emerged in Yunnan province and spread to South China through heroin trafficking routes. [3][4][5] CRF08_BC transmission was responsible for a large number of new infections in IDUs. A molecular epidemiology study showed that CRF08_BC was the dominant subtype (59.8%) in Yunnan Province in the newly reported cases.…”

Section: Introductionmentioning

confidence: 99%

In VitroSelection of HIV-1 CRF08_BC Variants Resistant to Reverse Transcriptase Inhibitors

Zhang

et al. 2015

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

Human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 08_BC (CRF08_BC), carrying the recombinant reverse transcriptase (RT) gene from subtypes B and C, has recently become highly prevalent in Southern China. As the number of patients increases, it is important to characterize the drug resistance mutations of CRF08_BC, especially against widely used antiretrovirals. In this study, clinically isolated virus (2007CNGX-HK), confirmed to be CRF08_BC with its sequence deposited in GenBank (KF312642), was propagated in human peripheral blood mononuclear cells (PBMCs) with increasing concentrations of nevirapine (NVP), efavirenz (EFV), or lamivudine (3TC). Three different resistance patterns led by initial mutations of Y181C, E138G, and Y188C were detected after the selection with NVP. Initial mutations, in combination with other previously reported substitutions (K20R, D67N, V90I, K101R/E, V106I/A, V108I, F116L, E138R, A139V, V189I, G190A, D218E, E203K, H221Y, F227L, N348I, and T369I) or novel mutations (V8I, S134N, C162Y, L228I, Y232H, E396G, and D404N), developed during NVP selection. EFV-associated variations contained two initial mutations (L100I and Y188C) and three other mutations (V106L, F116Y, and A139V). Phenotypic analyses showed that E138R, Y181C, and G190A contributed high-level resistance to NVP, while L100I and V106L significantly reduced virus susceptibility to EFV. Y188C was 20-fold less sensitive to both NVP and EFV. As expected, M184I alone, or with V90I or D67N, decreased 3TC susceptibility by over 1,000-fold. Although the mutation profile obtained in culture may be different from the patients, these results may still provide useful information to monitor and optimize the antiretroviral regimens.

show abstract

“…[9][10][11][12][13][14] Two closely related and well-known CRFs (CRF07_BC and CRF08_BC) circulating in China are believed to have come from these recombinants. 15,16 In recent years, infections by CRF01_AE have been increasing, and mosaic strains containing CRF01_AE fragments have also frequently arisen in this area, 11,12,17 which complicates the HIV-1 epidemic in Yunnan. In this study, we detected a novel HIV-1 circulating recombinant form, designated CRF65_cpx, by near full-length genome (NFLG) analysis, from four individuals with obvious epidemiological linkages.…”

mentioning

confidence: 99%

Identification of a Novel HIV Type 1 Circulating Recombinant Form (CRF65_cpx) Composed of CRF01_AE and Subtypes B and C in Western Yunnan, China

Feng

Wei

Hsi

et al. 2014

AIDS Research and Human Retroviruses

Self Cite

View full text Add to dashboard Cite

Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07_BC and CRF08_BC in East Asia: The relevance of genetic diversity and phylodynamics for vaccine strategies

Cited by 48 publications

References 40 publications

Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia

Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia

In VitroSelection of HIV-1 CRF08_BC Variants Resistant to Reverse Transcriptase Inhibitors

Identification of a Novel HIV Type 1 Circulating Recombinant Form (CRF65_cpx) Composed of CRF01_AE and Subtypes B and C in Western Yunnan, China

Contact Info

Product

Resources

About