2014
DOI: 10.1002/ejp.605
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Abstract: Protocols for testing conditioned pain modulation (CPM) vary between different labs/clinics. In order to promote research and clinical application of this tool, we summarize the recommendations of interested researchers consensus meeting regarding the practice of CPM and report of its results.

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Cited by 378 publications
(357 citation statements)
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References 7 publications
(10 reference statements)
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“…We examined CPM effects as a function of expectancy, drug, and presence of chronic back pain using a 3 Expectancy (no change in pain, pain increase, pain decrease) × 3 Drug (placebo, naloxone, morphine) × 2 Group (chronic low back pain, healthy) ANOVA of the change in mean heat pain ratings from pre-conditioning phase to the conditioning phase. Consistent with recommended guidelines [2, 31], changes during CPM were calculated so that pain reductions were represented as negative values (i.e., conditioning phase - pre-conditioning phase). In addition to the primary analysis, one-sample T-tests were conducted to determine whether change scores within each expectancy condition differed significantly from zero.…”
Section: Methodsmentioning
confidence: 99%
“…We examined CPM effects as a function of expectancy, drug, and presence of chronic back pain using a 3 Expectancy (no change in pain, pain increase, pain decrease) × 3 Drug (placebo, naloxone, morphine) × 2 Group (chronic low back pain, healthy) ANOVA of the change in mean heat pain ratings from pre-conditioning phase to the conditioning phase. Consistent with recommended guidelines [2, 31], changes during CPM were calculated so that pain reductions were represented as negative values (i.e., conditioning phase - pre-conditioning phase). In addition to the primary analysis, one-sample T-tests were conducted to determine whether change scores within each expectancy condition differed significantly from zero.…”
Section: Methodsmentioning
confidence: 99%
“…In 2015, experts recommended the term CPM for human application of DNIC protocols (Yarnitsky et al, 2015). A noxious stimulus applied in one part of the body can inhibit pain in another part of the body, by activating the descending inhibitory system (DNIC or CPM).…”
Section: Endogenous Mechanisms Of Pain Modulationmentioning
confidence: 99%
“…The different test protocols limit generalization of findings and thus a group of experts in the field presented recommendations regarding a standard measurement of CPM in healthy individuals and pain patients (Yarnitsky et al, 2010, 2015). Preferably, mechanical and heat TS should be delivered either at a fixed pain intensity of 40 on a 0–100 pain rating scale or at an ascending intensity and discontinued when pain intensity of 40/100 is reached.…”
Section: Cpm Protocolsmentioning
confidence: 99%
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“…Examining relations between visceral sensitivity and CPM represents an important avenue for future research. Second, the pain testing protocol was only partially in line with recent recommendations for CPM assessment due to our reliance on one type of test stimulus [54]. Replication of findings across other test stimuli is critical given recent meta-analytic evidence that relations between psychosocial factors and CPM differ according to the pain modality [30].…”
mentioning
confidence: 99%