Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles

Abstract

We conclude that there is no evidence of a difference between rhCG or rhLH and uhCG for live birth or ongoing pregnancy rates or rates of OHSS.

GnRH agonist trigger in poor prognosis patients undergoing a multicycle approach through DuoStim or consecutive stimulations: a SWOT analysis

“…On the contrary, no significant differences resulted between r-hCG and GnRH agonist triggers [13]. This finding conflicts with data reported by previous studies, showing comparable results following urinary and recombinant hCG triggers in patients undergoing conventional long GnRH-agonist protocol with fresh embryo transfer [52].…”

GnRH agonist trigger in poor prognosis patients undergoing a multicycle approach through DuoStim or consecutive stimulations: a SWOT analysis

“…On the contrary, no significant differences resulted between r-hCG and GnRH agonist triggers [13]. This finding conflicts with data reported by previous studies, showing comparable results following urinary and recombinant hCG triggers in patients undergoing conventional long GnRH-agonist protocol with fresh embryo transfer [52].…”

Randomized Pharmacokinetic Study of a Highly Purified Human Chorionic Gonadotropin and of a Recombinant Human Chorionic Gonadotropin Following Single Subcutaneous Administration in Healthy Women

“…This gives additional evidence that administration of the two preparations can result in different pharmacokinetic profiles although no difference in efficacy between r-hCG and u-hCG has been observed [10,15,16]. Notably, all women enrolled in this study had a normal menstrual cycle and were pituitary suppressed using their usual combined oral hormonal contraceptives reducing the levels of endogenous FSH < 4 IU/L and LH < 5IU/L, which is considered a marker of an appropriate gonadotropin suppression [17].…”

Clinical outcomes of assisted reproductive technology treatment by using a self‐injection of recombinant human chorionic gonadotropin as the final maturation trigger

“…In these reports, the GnRH-a long protocol was used for ovarian stimulation and the number of oocytes retrieved per patient and the clinical pregnancy rate were similar between the r-hCG and u-hCG. 8,9 In contrast, the incidence of adverse events of injection site reaction (eg, redness, swelling) was lower with r-hCG, compared with u-hCG. 10 This difference may be attributed to fewer contaminating proteins in the r-hCG.…”

GnRH agonist trigger in poor prognosis patients undergoing a multicycle approach through DuoStim or consecutive stimulations: a SWOT analysis

“…On the contrary, no significant differences resulted between r-hCG and GnRH agonist triggers [13]. This finding conflicts with data reported by previous studies, showing comparable results following urinary and recombinant hCG triggers in patients undergoing conventional long GnRH-agonist protocol with fresh embryo transfer [52].…”

Randomized Pharmacokinetic Study of a Highly Purified Human Chorionic Gonadotropin and of a Recombinant Human Chorionic Gonadotropin Following Single Subcutaneous Administration in Healthy Women

“…This gives additional evidence that administration of the two preparations can result in different pharmacokinetic profiles although no difference in efficacy between r-hCG and u-hCG has been observed [10,15,16]. Notably, all women enrolled in this study had a normal menstrual cycle and were pituitary suppressed using their usual combined oral hormonal contraceptives reducing the levels of endogenous FSH < 4 IU/L and LH < 5IU/L, which is considered a marker of an appropriate gonadotropin suppression [17].…”

Clinical outcomes of assisted reproductive technology treatment by using a self‐injection of recombinant human chorionic gonadotropin as the final maturation trigger

“…In these reports, the GnRH-a long protocol was used for ovarian stimulation and the number of oocytes retrieved per patient and the clinical pregnancy rate were similar between the r-hCG and u-hCG. 8,9 In contrast, the incidence of adverse events of injection site reaction (eg, redness, swelling) was lower with r-hCG, compared with u-hCG. 10 This difference may be attributed to fewer contaminating proteins in the r-hCG.…”

GnRH agonist trigger in poor prognosis patients undergoing a multicycle approach through DuoStim or consecutive stimulations: a SWOT analysis

“…On the contrary, no significant differences resulted between r-hCG and GnRH agonist triggers [13]. This finding conflicts with data reported by previous studies, showing comparable results following urinary and recombinant hCG triggers in patients undergoing conventional long GnRH-agonist protocol with fresh embryo transfer [52].…”

Randomized Pharmacokinetic Study of a Highly Purified Human Chorionic Gonadotropin and of a Recombinant Human Chorionic Gonadotropin Following Single Subcutaneous Administration in Healthy Women

“…This gives additional evidence that administration of the two preparations can result in different pharmacokinetic profiles although no difference in efficacy between r-hCG and u-hCG has been observed [10,15,16]. Notably, all women enrolled in this study had a normal menstrual cycle and were pituitary suppressed using their usual combined oral hormonal contraceptives reducing the levels of endogenous FSH < 4 IU/L and LH < 5IU/L, which is considered a marker of an appropriate gonadotropin suppression [17].…”

Clinical outcomes of assisted reproductive technology treatment by using a self‐injection of recombinant human chorionic gonadotropin as the final maturation trigger

“…In these reports, the GnRH-a long protocol was used for ovarian stimulation and the number of oocytes retrieved per patient and the clinical pregnancy rate were similar between the r-hCG and u-hCG. 8,9 In contrast, the incidence of adverse events of injection site reaction (eg, redness, swelling) was lower with r-hCG, compared with u-hCG. 10 This difference may be attributed to fewer contaminating proteins in the r-hCG.…”