Recombinant human growth hormone for treating burns and donor sites

Current understanding of thermo(dys)regulation in severe burn injury and the pathophysiological influence of hypermetabolism, adrenergic stress and hypothalamic regulation—a systematic review

“…Additionally, catabolic hypermetabolism may further be mitigated with the use of anabolic and anticatabolic drugs such as testosterone or oxandrolone [ 66 ] while recombinant human growth hormone has also been investigated in this capacity [ 18 ], all aiming to reduce protein catabolism and restore hormonal balance. Recombinant human growth hormone has been shown to stimulate wound healing, both of the actual burn wound and of the donor site for skin grafts, although study populations are often small and substantial bias exists [ 77 ].…”

Current understanding of thermo(dys)regulation in severe burn injury and the pathophysiological influence of hypermetabolism, adrenergic stress and hypothalamic regulation—a systematic review

“…Additionally, catabolic hypermetabolism may further be mitigated with the use of anabolic and anticatabolic drugs such as testosterone or oxandrolone [ 66 ] while recombinant human growth hormone has also been investigated in this capacity [ 18 ], all aiming to reduce protein catabolism and restore hormonal balance. Recombinant human growth hormone has been shown to stimulate wound healing, both of the actual burn wound and of the donor site for skin grafts, although study populations are often small and substantial bias exists [ 77 ].…”

Poor methodological quality and reporting standards of systematic reviews in burn care management

“…Of those, we excluded an additional 59 studies because they failed to meet the methodological definition of systematic review as per our inclusion criteria . Therefore, a total of 60 systematic reviews formed the basis of this study …”

Immunological and microbiological periodontal profiles in isolated growth hormone deficiency

“…GHD itself could lead to changes in the disease progression, since GH usually stimulates proliferation/differentiation and thus wound healing, and consequently its absence or deficiency may also have a role in the tissue breakdown, as suggested by the presence of deeper periodontal pockets in our IGHD group. In this context, devices containing recombinant human GH (rhGH) are already being developed and have shown clinical efficacy, increasing protein synthesis and accelerating the healing rate of burn wounds . GHRH itself can also improve wound healing in diabetic complications and similar activity was observed on outcomes following peripheral nerve injury, and in the treatment of corneal epithelial defects .…”

Current understanding of thermo(dys)regulation in severe burn injury and the pathophysiological influence of hypermetabolism, adrenergic stress and hypothalamic regulation—a systematic review

“…Additionally, catabolic hypermetabolism may further be mitigated with the use of anabolic and anticatabolic drugs such as testosterone or oxandrolone [ 66 ] while recombinant human growth hormone has also been investigated in this capacity [ 18 ], all aiming to reduce protein catabolism and restore hormonal balance. Recombinant human growth hormone has been shown to stimulate wound healing, both of the actual burn wound and of the donor site for skin grafts, although study populations are often small and substantial bias exists [ 77 ].…”

Poor methodological quality and reporting standards of systematic reviews in burn care management

“…Of those, we excluded an additional 59 studies because they failed to meet the methodological definition of systematic review as per our inclusion criteria . Therefore, a total of 60 systematic reviews formed the basis of this study …”

Immunological and microbiological periodontal profiles in isolated growth hormone deficiency

“…GHD itself could lead to changes in the disease progression, since GH usually stimulates proliferation/differentiation and thus wound healing, and consequently its absence or deficiency may also have a role in the tissue breakdown, as suggested by the presence of deeper periodontal pockets in our IGHD group. In this context, devices containing recombinant human GH (rhGH) are already being developed and have shown clinical efficacy, increasing protein synthesis and accelerating the healing rate of burn wounds . GHRH itself can also improve wound healing in diabetic complications and similar activity was observed on outcomes following peripheral nerve injury, and in the treatment of corneal epithelial defects .…”

Current understanding of thermo(dys)regulation in severe burn injury and the pathophysiological influence of hypermetabolism, adrenergic stress and hypothalamic regulation—a systematic review

“…Additionally, catabolic hypermetabolism may further be mitigated with the use of anabolic and anticatabolic drugs such as testosterone or oxandrolone [ 66 ] while recombinant human growth hormone has also been investigated in this capacity [ 18 ], all aiming to reduce protein catabolism and restore hormonal balance. Recombinant human growth hormone has been shown to stimulate wound healing, both of the actual burn wound and of the donor site for skin grafts, although study populations are often small and substantial bias exists [ 77 ].…”

Poor methodological quality and reporting standards of systematic reviews in burn care management

“…Of those, we excluded an additional 59 studies because they failed to meet the methodological definition of systematic review as per our inclusion criteria . Therefore, a total of 60 systematic reviews formed the basis of this study …”

Immunological and microbiological periodontal profiles in isolated growth hormone deficiency

“…GHD itself could lead to changes in the disease progression, since GH usually stimulates proliferation/differentiation and thus wound healing, and consequently its absence or deficiency may also have a role in the tissue breakdown, as suggested by the presence of deeper periodontal pockets in our IGHD group. In this context, devices containing recombinant human GH (rhGH) are already being developed and have shown clinical efficacy, increasing protein synthesis and accelerating the healing rate of burn wounds . GHRH itself can also improve wound healing in diabetic complications and similar activity was observed on outcomes following peripheral nerve injury, and in the treatment of corneal epithelial defects .…”