Receptor Pharmacology and Other Relevant Factors in Lower Urinary Tract Pathology Under a Functional and Toxicological Approach: Instrument to Better Manage Antimicrobials Therapy.

Abstract

In various patients' conditions involved in lower urinary tract disease LUT (like overactive bladder, bladder neck sclerosis, dis-synergy (without synergic contraction between bladder detrusor and bladder neck, BPH, recurrent cystitis, interstitial cystitis, chronic prostatitis, ureteral stenosis, loss of sphincteric coordination. Prostatic cancer, anatomic abnormalities and other the receptor status play relevant role to reduce effect of vicious cycle that can be responsible in progression of these pathologic process. In this work the complex raptorial status is analyzed to verify new therapeutic strsategies. Starting from the observation that various irritant substanties produce irritant stimulus in Prostatic Patients or in bladder neck condition is interesting to deep understand the etiopathogenesis and Functional results. In Various prostatic, bladder neck or ureteral condition a reduced urinary floss can produce infectious. Conditions like acute or chronic prostatitis.Irritants substanties in diet (in example exilic alcohol drink, hot spices, crud meats, carbonate drinks, caffeine and other) can produce Painful stimulus in innervations of vesical trigon us, bladder neck and prostatic urethra. The same recurrent cystitis and Bhp contribute in a complex situation. This stimulus produces Petronus of bladder muscle involved in the expulsion of urine. The event related inflammation and edema (bladder, prostatic urethra, trigonums) contribute to the global effect. So, conditions like bladder neck sclerosis IPB, recurrent prostatitis and cystitis in acts in a vicious circle. (also, immunomodulated: Bhp and chronic prostatitis with lymphocyte infiltration and tissue remodeling). The hormonal status checks the systems (see 5-ARI efficacy in Bhp). Simpatico, paradigmatic and other system are deeply involved. Also, behavioral habits or diet can influence in example urinary flux in a complex system like LUT. (Bladder and prostatic irritants that can produce edema and acute inflammation). Other behavior habits are deeply involved as too much sedentary, water intake, coffee, pee modality and also psychological profile and stressing conditions. Some disease like diabetes produce high consequences in all this system due to Bladder modification, oxidative stress, osmotic moves, and increase susceptibility of urinary infections. This article is verified this kind of moves that contribute in physio -pathology of some low urinary tract conditions. The anatomic abnormalities produce, obviously, physiological dysfunctions, Recurrent urinary tract infections, inadequate antimicrobial therapy, profile of resistance, duration of therapy, kind of antimicrobials, posology, Pk Kinetics, associations, compliance, biofilms, microcalcifications (recurrent chronic prostatitis) contribute to a progression of the condition.