Recent trends in natural polysaccharide based bioinks for multiscale 3D printing in tissue regeneration: A review

Mahendiran, Balaji; Muthusamy, Shalini; Sampath, S.; Jaisankar, Sellamuthu N.; Popat, Ketul C.; Selvakumar, R.; Krishnakumar, Gopal Shankar

doi:10.1016/j.ijbiomac.2021.04.179

Cited by 74 publications

(44 citation statements)

References 210 publications

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“…Pectin is an anionic heteropolysaccharide with gelling properties, extracted from citrus fruits [ 19 , 20 ]. Depending on the esterification degree, pectin can be classified as high or low methoxy pectin [ 21 ]. Pectin is highly available, biodegradable, and non-toxic, which makes it a potential material for biomedical applications [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Zarandona

Bengoechea

Álvarez‐Castillo

et al. 2021

Gels

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Chitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccharides, as observed by FTIR analysis. Since systems with high concentration of pectin showed aggregations, the system composed of 2 wt% chitosan and 2 wt% pectin (CHI2PEC2) was selected for 3D printing. 3D printed scaffolds showed good shape accuracy, and SEM and XRD analyses revealed a homogeneous and amorphous structure. Moreover, scaffolds were stable and kept their shape and size after a cycle of compression sweeps. Their integrity was also maintained after immersion in PBS at 37 °C, showing a high swelling capacity, suitable for exudate absorption in wound healing applications.

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Section: Introductionmentioning

confidence: 99%

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Zarandona

Bengoechea

Álvarez‐Castillo

et al. 2021

Gels

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“…Structural shrinkage due to component extraction and structural expansion due to solvent addition often lead to weakening effects such as disintegration and destruction [ 48 , 49 ]. In contrast, natural living tissues, such as skeletal muscle, become stronger with a continuous supply of water and amino acids after repeated growth cycles, forming new components within the original tissue [ 50 , 51 ]. The researchers exploited this self-growth and self-reinforcing phenomenon to design smart materials with dynamic and programmable properties.…”

Section: Applications Of 3d Printed Soft Materialsmentioning

confidence: 99%

3D Printing Soft Matters and Applications: A Review

Zhan

Guo

Cao

et al. 2022

IJMS

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The evolution of nature created delicate structures and organisms. With the advancement of technology, especially the rise of additive manufacturing, bionics has gradually become a popular research field. Recently, researchers have concentrated on soft robotics, which can mimic the complex movements of animals by allowing continuous and often responsive local deformations. These properties give soft robots advantages in terms of integration and control with human tissue. The rise of additive manufacturing technologies and soft matters makes the fabrication of soft robots with complex functions such as bending, twisting, intricate 3D motion, grasping, and stretching possible. In this paper, the advantages and disadvantages of the additive manufacturing process, including fused deposition modeling, direct ink writing, inkjet printing, stereolithography, and selective laser sintering, are discussed. The applications of 3D printed soft matter in bionics, soft robotics, flexible electronics, and biomedical engineering are reviewed.

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“…A novel plant-based nanocellulose hydrogel has been developed at a low cost and the mechanical properties observed were similar to the popular standard Engel-Holm Swarm matrix derived from the basement membrane of mouse sarcoma [ 59 ]. Nanocellulose and alginate are the leading potential biomaterials for 3D bioprinting [ 62 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel based tissue engineering and its future applications in personalized disease modeling and regenerative therapy

Chaudhary

Chakraborty

2022

Beni-Suef Univ J Basic Appl Sci

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Background Evolution in the in vitro cell culture from conventional 2D to 3D technique has been a significant accomplishment. The 3D culture models have provided a close and better insight into the physiological study of the human body. The increasing demand for organs like liver, kidney, and pancreas for transplantation, rapid anti-cancer drug screening, and the limitations associated with the use of animal models have attracted the interest of researchers to explore 3D organ culture. Main body Natural, synthetic, and hybrid material-based hydrogels are being used as scaffolds in 3D culture and provide 'close-to-in vivo’ structures. Organoids: the stem cell-derived small size 3D culture systems are now favored due to their ability to mimic the in-vivo conditions of organ or tissue and this characteristic has made it eligible for a variety of clinical applications, drug discovery and regenerative medicine are a few of the many areas of application. The use of animal models for clinical applications has been a long-time ethical and biological challenge to get accurate outcomes. 3D bioprinting has resolved the issue of vascularization in organoid culture to a great extent by its layer-by-layer construction approach. The 3D bioprinted organoids have a popular application in personalized disease modeling and rapid drug development and therapeutics. Short conclusions This review paper, focuses on discussing the novel organoid culture approach, its advantages and limitations, and potential applications in a variety of life science areas namely cancer research, cell therapy, tissue engineering, and personalized medicine and drug discovery. Graphical Abstract

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Recent trends in natural polysaccharide based bioinks for multiscale 3D printing in tissue regeneration: A review

Cited by 74 publications

References 210 publications

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

3D Printing Soft Matters and Applications: A Review

Hydrogel based tissue engineering and its future applications in personalized disease modeling and regenerative therapy

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