2019
DOI: 10.24820/ark.5550190.p010.988
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Recent syntheses of steroidal derivatives containing heterocycles

Abstract: It was found that the introduction of a heterocycle or replacement by a heteroatom of one or more carbon atoms in the steroidal moiety could have a significant biological impact, and there has been much progress in the field of steroidal derivatives since. Recent developments in the syntheses of steroidal derivatives containing heterocycles are described herein.

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Cited by 15 publications
(4 citation statements)
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“…On the other hand, steroids constitute an extensive and essential class of biologically active polycyclic compounds which are widely used for therapeutic purposes . For instance, the most abundant endogenous steroid hormone in humans 3β‐hydroxy‐5‐androsten‐17‐one (dehydroepiandrosterone, DHEA), is a potent neurosteroid that can be used as anchoring molecular receptor on cell surfaces .…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, steroids constitute an extensive and essential class of biologically active polycyclic compounds which are widely used for therapeutic purposes . For instance, the most abundant endogenous steroid hormone in humans 3β‐hydroxy‐5‐androsten‐17‐one (dehydroepiandrosterone, DHEA), is a potent neurosteroid that can be used as anchoring molecular receptor on cell surfaces .…”
Section: Introductionmentioning
confidence: 99%
“…A number of excellent reviews on synthetic strategies directed towards the synthesis of heterosteroids have emerged in recent years [6,7]. Some of them focused on heterocycles [8], including fused-thiazoles [9], pyrazolines [10], bicyclic pyridines [11], and pyrimidines [12].…”
Section: Introductionmentioning
confidence: 99%
“…Even after decades of research, the total synthesis of steroid nuclei by improved strategies continues to receive considerable attention. Numerous methods [28][29][30][31][32][33][34] have been exploited for the total synthesis of steroids which are widely distributed in nature, and which possess practical medical importance. Research into steroid total synthesis continues to this day.…”
Section: Introductionmentioning
confidence: 99%