Recent studies on pinene and its biological and pharmacological activities

Park, Byung Bae; An, Ji Young; Park, Sang Un

doi:10.17179/excli2021-3714

Cited by 7 publications

(4 citation statements)

References 52 publications

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“…These can be found in the essential oils of coniferous trees (pine), and in turpentine, rosemary, and lavender [ 13 ]. One of the most relevant pinenes is α-pinene, which presents antifungal activity against C. albicans , C. parapsilosis , and C. tropicalis [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

α-Pinene: Docking Study, Cytotoxicity, Mechanism of Action, and Anti-Biofilm Effect against Candida albicans

et al. 2023

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Candida albicans is associated with serious infections in immunocompromised patients. Terpenes are natural-product derivatives, widely studied as antifungal alternatives. In a previous study reported by our group, the antifungal activity of α-pinene against C. albicans was verified; α-pinene presented an MIC between 128–512 µg/mL. In this study, we evaluate time-kill, a mechanism of action using in silico and in vitro tests, anti-biofilm activity against the Candida albicans, and toxicity against human cells (HaCaT). Results from the molecular-docking simulation demonstrated that thymidylate synthase (−52 kcal mol−1), and δ-14-sterol reductase (−44 kcal mol−1) presented the best interactions. Our in vitro results suggest that α-pinene’s antifungal activity involves binding to ergosterol in the cellular membrane. In the time-kill assay, the antifungal activity was not time-dependent, and also inhibited biofilm formation, while rupturing up to 88% of existing biofilm. It was non-cytotoxic to human keratinocytes. Our study supports α-pinene as a candidate to treat fungal infections caused by C. albicans.

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Section: Introductionmentioning

confidence: 99%

α-Pinene: Docking Study, Cytotoxicity, Mechanism of Action, and Anti-Biofilm Effect against Candida albicans

et al. 2023

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“…Thus, predictably that, α-pinene monoterpenoid which represents more than (75%) T. distichum oil is responsible for its bioactivity. In recent reports α-pine-ne exhibits antimicrobial and anti-inflammatory properties and acts as a broad-spectrum antibiotic also an acetyl cholinesterase modulator (Pajaro et al, 2017, Salehi et al;2019 andPark, et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Reinforce the Silkworms' Nutrition Using Essential Oil of Taxodium distichum' Fruits: A Prospective Way to Improve Silk Production

Sabry,

Saad,

El Shafiey

2023

Catrina: The International Journal of Environmental Sciences

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Silkworms, being an important source of silk fiber, require adequate nutrition for optimal growth and cocoon formation. However, conventional methods often fall short in meeting their dietary requirements. The present study aimed to evaluate the potential of Taxodium distichum essential oil as a natural product to enhance vitality and silk production in the 5 th larval instar of Bombyx mori, commonly known as mulberry silkworm. The investigation involved employing biochemical and histological approaches. Among the different concentrations tested, a 1% oil concentration exhibited the most significant effects on larval weight (5.004 g), silk gland weight (1.378 g), fresh cocoon weight (1.772 g), and cocoon shell weight (0.386 g) when compared to non-treated larvae. Furthermore, this concentration also resulted in notable improvements in several silk-related parameters such as cocoon silk ratio (21.89%), length of the silk thread (1272.96 m), weight of filament silk (0.390 g), and size of the silk filament measured at 2.212 denier (dn) when compared to other used concentrations and control groups. The tested oil was identified through GC/MS analysis, which revealed that α-pinene was the major compound, representing 74.36% of the total oil composition. Small amounts of other compounds were also identified, including Cis-Thujopsene (8.39%), Sabinene (4.09%), β-Pinene (3.08%), α-Myrcene (2.19%), and Bornyl acetate (1.34%). Histological investigation of larval brains showed no noticeable abnormal pathological changes in treated larvae compared to the negative control group. Observations revealed that the neural lamella extended continuously around the brain in a regular manner, with a dense layer consisting of neurons and glial cells beneath it. The essential oil from T. distichum induced significant biochemical changes in treated larvae, leading to decreased activity of acetylcholinesterase and increased activity levels of Glutathione Stransferase, Superoxide dismutase, Catalase, and Malondialdehyde when compared to their respective negative control group. In conclusion, treatment with T.distichum essential oil enhanced larval vitality in mulberry silkworms (Bombyx mori), preserved their brain structure, and improved silk production by promoting an antioxidant defense system against oxidative stress

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“…Pinene, a well-known group of monoterpenes (C 10 H 16 ), is the primary constituent of turpentine extracted through resin distillation from various coniferous trees, notably those of the Pinus genus [75,76]. The two structural isomers, α-pinene and β-pinene, are also abundant in various herbs, including rosemary, parsley, basil, and even citrus peels, contributing to their distinctive aromas and properties [77][78][79]. The monoterpene hydrocarbon α-pinene was found in many essential oils when testing for the nematicidal activity of EO compounds.…”

Section: Pinenementioning

confidence: 99%

Recent Advances and Developments in the Nematicidal Activity of Essential Oils and Their Components against Root-Knot Nematodes

Sarri,

Mourouzidou,

Ntalli

et al. 2024

Agronomy

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The Meloidogyne genus is widely recognized for its significant economic and scientific importance within the group of plant-parasitic nematodes. The chemical management of nematodes presents its challenges and heavily depends on employing soil fumigants containing toxic and costly nematicides. However, plant-derived essential oils offer promising alternatives, demonstrating a wide range of biological activities that affect nematodes through a range of mechanisms, including disrupting their nervous systems, inducing detrimental effects on plasma membrane permeability, penetrating the gelatinous matrix of nematode eggs, and disturbing intracellular redox status. Most of the extracted essential oils were predominantly sourced from the Lamiaceae family (32%), followed by Asteraceae (11%), Apiaceae (9%), and Poaceae (8%), and with genera Thymus, Mentha, Ocimum, Artemisia, Cymbopogon being the most common. The nematicidal activity of EOs primarily arises from their chemical groups, such as terpenes, phenylpropanoids, and organosulfur compounds. Among these, geraniol, carvacrol, limonene, eugenol, thymol, and pinene demonstrate the strongest nematicidal potential. The assessed EO efficacy was evaluated against 6 species belonging to the genus Meloidogyne. This review also provides knowledge of synergistic and antagonistic interactions of EO components. Synergistic interactions were identified between carvacrol and geraniol, as well as geraniol and eugenol, whereas binary combinations of carvacrol, γ-terpinene, and o-cymene exhibited reduced efficacy. Understanding how specific compounds interact can lead to the development of more potent and effective final products.

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Recent studies on pinene and its biological and pharmacological activities

Cited by 7 publications

References 52 publications

α-Pinene: Docking Study, Cytotoxicity, Mechanism of Action, and Anti-Biofilm Effect against Candida albicans

α-Pinene: Docking Study, Cytotoxicity, Mechanism of Action, and Anti-Biofilm Effect against Candida albicans

Reinforce the Silkworms' Nutrition Using Essential Oil of Taxodium distichum' Fruits: A Prospective Way to Improve Silk Production

Recent Advances and Developments in the Nematicidal Activity of Essential Oils and Their Components against Root-Knot Nematodes

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