Recent progress in understanding aldosterone secretion

Foster, Richard H.; MacFarlane, Catriona H.; Bustamante, Mirta O.

doi:10.1016/s0306-3623(96)00290-x

Cited by 44 publications

(25 citation statements)

References 61 publications

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“…Production of aldosterone occurs in the adrenal glomerulosa, which is regulated primarily by angiotensin II (Ang II) and potassium and, to a lesser degree, adrenocorticotropin (ACTH) (1,2). In the presence of these aldosterone stimulators, steroidogenesis in the adrenal cortex is further governed by local autocrine and/or paracrine factors (3).…”

Section: Introductionmentioning

confidence: 99%

Aldosterone breakthrough caused by chronic blockage of angiotensin II type 1 receptors in human adrenocortical cells: Possible involvement of bone morphogenetic protein-6 actions

Otani¹,

Otsuka²,

Makino³

2010

Okayama I. Z.

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AbbreviationsCo-treatment with candesartan reversed the inhibitory effects of Ang II on the expression levels of these mRNAs. The breakthrough phenomenon was attenuated by neutralization of endogenous BMP-6 and ALK-2. Collectively, these data suggest that changes in BMP-6 availability and response may be involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB.

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Section: Introductionmentioning

confidence: 99%

Aldosterone breakthrough caused by chronic blockage of angiotensin II type 1 receptors in human adrenocortical cells: Possible involvement of bone morphogenetic protein-6 actions

Otani¹,

Otsuka²,

Makino³

2010

Okayama I. Z.

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“…ACTH is known to increase aldosterone secretion by a renin-angiotensin system (RAS)-independent pathway [63]. Angiotensin II can induce peripheral vasoconstriction [64][65][66], which may be beneficial to diving marine mammals experiencing acute stressors, but which may also result in an increase in aldosterone production.…”

mentioning

confidence: 99%

Metabolic responses to adrenocorticotropic hormone (ACTH) vary with life-history stage in adult male northern elephant seals

Ensminger

Somo

Houser

et al. 2014

General and Comparative Endocrinology

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“…A ldosterone is widely known as a mineralocorticoid hormone involved in the regulation of blood electrolyte concentration and physiological volume homeostasis (1). These processes require the interaction of aldosterone and the mineralocorticoid receptor (MR), an intracellular receptor expressed by cells of target organs, such as kidneys.…”

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confidence: 99%

Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity

Herrada

Contreras

Marini

et al. 2009

The Journal of Immunology

156

120

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Excessive production of aldosterone leads to the development of hypertension and cardiovascular disease by generating an inflammatory state that can be promoted by T cell immunity. Because nature and intensity of T cell responses is controlled by dendritic cells (DCs), it is important to evaluate whether the function of these cells can be modulated by aldosterone. In this study we show that aldosterone augmented the activation of CD8+ T cells in a DC-dependent fashion. Consistently, the mineralocorticoid receptor was expressed by DCs, which showed activation of MAPK pathway and secreted IL-6 and TGF-b in response to aldosterone. In addition, DCs stimulated with aldosterone impose a Th17 phenotype to CD4+ T cells, which have recently been associated with the promotion of inflammatory and autoimmune diseases. Accordingly, we observed that aldosterone enhances the progression of experimental autoimmune encephalomyelitis, an autoimmune disease promoted by Th17 cells. In addition, blockade of the mineralocorticoid receptor prevented all aldosterone effects on DCs and attenuated experimental autoimmune encephalomyelitis development in aldosterone-treated mice. Our data suggest that modulation of DC function by aldosterone enhances CD8+ T cell activation and promotes Th17-polarized immune responses, which might contribute to the inflammatory damage leading to hypertension and cardiovascular disease.This work was supported by Fondo Nacional de Desarrollo Científico y Tecnológico Grants 1070352, 1070876, 1050265, 1050690 and 1050979; Fondo de Fomento al Desarrollo Científico y Tecnológico Grant D04I1075; INCO-CT-2006-032296; and Millennium Nucleus on Immunology and Immunotherapy (P04/030-F).A.A.H., P.A.G, and C.A.A. are fellows of Comisión Nacional de Investigación Científica y Tecnológica

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Recent progress in understanding aldosterone secretion

Cited by 44 publications

References 61 publications

Aldosterone breakthrough caused by chronic blockage of angiotensin II type 1 receptors in human adrenocortical cells: Possible involvement of bone morphogenetic protein-6 actions

Aldosterone breakthrough caused by chronic blockage of angiotensin II type 1 receptors in human adrenocortical cells: Possible involvement of bone morphogenetic protein-6 actions

Metabolic responses to adrenocorticotropic hormone (ACTH) vary with life-history stage in adult male northern elephant seals

Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity

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