Recent progress in NIR-II emitting lanthanide-based nanoparticles and their biological applications

Ding, Shenggang; Lu, Lingfei; Fan, Yong; Zhang, Fan

doi:10.1016/j.jre.2020.01.021

Cited by 60 publications

(43 citation statements)

References 90 publications

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“…Secondly, the rapid development of bright SWIR probes made of organic 12 and inorganic materials such as quantum dots [13][14][15] , lanthanide nanoparticles 16,17 , and metal nanoclusters [18][19][20] has contributed to improve the sensitivity of detection in artificial models and also in vivo in small animals. For example, ultra-small gold nanoparticles with diameters smaller than 3 nm, namely gold nanoclusters (Au NCs), have shown relatively high quantum yields with photoluminescence that could be detected above 1250 nm accompanied with a renal clearance when injected in mice 18,20 .…”

Section: Reviewer:mentioning

confidence: 99%

Optimization of spatial resolution and scattering effects for biomedical fluorescence imaging by using sub‐regions of the shortwave infrared spectrum

Musnier

Henry

Vollaire

et al. 2020

Journal of Biophotonics

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We evaluated the impact of light-scattering effects on spatial resolution in different SWIR subregions by analyzing two SWIR emissive phantoms made of PDMS-gold nanoclusters (Au NCs) composite covered with mice skin, or capillary tubes filled with Au NCs or IRDye 800CW at different depth in intralipids and finally, after administration of the Au NCs intravenously in mice. Our findings highlighted the benefit of working at the highest tested spectral range of the SWIR region with a 50% enhancement of spatial resolution measured in artificial model when moving from NIR-II (1000-1300 nm) to NIR-IIa (1300-1450 nm) region, and a 25% reduction of the scattering from the skin determined by point spread function analysis from the NIR-II to NIR-IIb region (1500-1700 nm). We also confirmed that a series of Monte Carlo restoration of images significantly improved the spatial resolution in vivo in mice in deep tissues both in the NIR-II and NIR-IIa spectral windows.

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Section: Reviewer:mentioning

confidence: 99%

Optimization of spatial resolution and scattering effects for biomedical fluorescence imaging by using sub‐regions of the shortwave infrared spectrum

Musnier

Henry

Vollaire

et al. 2020

Journal of Biophotonics

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“…Optical multiplexing has attracted considerable attention and plays an important role in the field of data storage, document encryption, anti‐counterfeiting, time‐resolved bioimaging, and more. [ 1–7 ] To date, multiplexing using luminescence colors or intensity of fluorophores has been reported previously. [ 8,9 ] However, color or intensity based multiplexing is limited by the crowded spectral domain and background interference, leading to inevitable spectral overlap thus complicated optical imaging devices and tedious color compensations are required.…”

Section: Figurementioning

confidence: 99%

Lifetime‐Engineered Carbon Nanodots for Time Division Duplexing

Liang

Liu

et al. 2021

Advanced Science

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Optical multiplexing attracts considerable attention in the field of information encryption, optical probe, and time‐resolved bioimaging. However, the optical multiplexing based on rare‐earth nanoparticles suffers from heavy metal elements and relatively short lifetimes; sophisticated facilities are thus needed. Herein, time division duplexing based on eco‐friendly carbon nanodots (CNDs) with manipulative luminescence lifetimes is demonstrated. In a single green color emission channel, the luminescence lifetimes of the CNDs can be manipulated from nanosecond level to second level by introducing water, while the lifetime of the CNDs confined by a silica shell stays. Time division duplexing based on the CNDs and CNDs@silica with distinct lifetimes is realized and spatio‐temporal overlapping information is thus resolved. High‐level information encryption using the time division duplexing technology is realized. This work may promise the potential applications of CNDs in multi‐lifetime channels biological imaging, high‐density information storage, and anti‐counterfeiting.

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“…FLI is a widely used imaging modality in the NIR‐II region that benefited from the fast development of the NIR‐II fluorescent nanomaterials and dyes 15 . Up to now, there were several types of materials that have been demonstrated for NIR‐II FLI, such as semiconducting single‐walled carbon nanotubes, 16,17 quantum dots (QDs), 18‐22 lanthanide‐doped nanoparticles, 23‐26 and organic dyes 27‐32 . Due to the minimized tissue scattering and absorption, these NIR‐II FLI contrast agents provide significantly enhanced signal‐to‐noise ratio and has achieved high‐quality imaging for a fine structure of vascular and tumor imaging in deep tissues 28,29,33 …”

Section: Imaging Modalities In the Nir‐ii Regionmentioning

confidence: 99%

Cancer nanotheranostics in the second near‐infrared window

Jiang

Huang

et al. 2020

VIEW

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Nanotheranostics is an attractive and fast developing nanomedicine technology that integrates both diagnostics and therapeutics in a single nanoplatform. It ensures consistent spatiotemporal distribution and uniform targeting of the imaging and therapeutic agents, thus desirable for real‐time monitoring of in situ therapeutic effects and long‐term tailorable therapeutics in accordance to disease prognosis for personalized medicine. Optical stimuli of nanotheranostics offer easy and precise controllability to combat cancer. Compared with the conventional use of visible and the first near‐infrared region light, using the second near‐infrared (NIR‐II) region light as the incident excitation enables cancer nanotheranostics to go deeper and with enhanced theranostic efficiency. Realizing the extraordinary advantages of accomplishing cancer nanotheranostics in the NIR‐II region, burgeoning research efforts were devoted to this field. This review aims to analyze the available imaging and therapeutic approaches to realize nanotheranostics in the NIR‐II region, and to summarize the current applications of cancer nanotheranostics in the NIR‐II region. In the end, we will discuss the challenges and outlook on the possible perspectives in the field.

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Recent progress in NIR-II emitting lanthanide-based nanoparticles and their biological applications

Cited by 60 publications

References 90 publications

Optimization of spatial resolution and scattering effects for biomedical fluorescence imaging by using sub‐regions of the shortwave infrared spectrum

Optimization of spatial resolution and scattering effects for biomedical fluorescence imaging by using sub‐regions of the shortwave infrared spectrum

Lifetime‐Engineered Carbon Nanodots for Time Division Duplexing

Cancer nanotheranostics in the second near‐infrared window

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