Recent progress in Mg-based alloys as a novel bioabsorbable biomaterials for orthopedic applications

Xing, Fei; Li, Shang; Yin, Dongdi; Xie, Jichang; Rommens, Pol Maria; Xiang, Zhou; Liu, Ming; Ritz, Ulrike

doi:10.1016/j.jma.2022.02.013

Cited by 85 publications

(32 citation statements)

References 203 publications

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“…The mechanical match between the material and the biological organism during the implantation and functionalization of the material also influences the service effect of the implant in the damaged area. Too low modulus of elasticity can reduce the medical therapeutic impact of the alloy, while the too high modulus of elasticity can lead to stress shielding problems ( Uppal et al, 2022 ; Xing et al, 2022 ). Therefore, Bio-HEA should not be pursued for high-strength mechanical properties but should be consistent with human tissues, close to or complete the therapeutic effect before failure.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Bio-high entropy alloys: Progress, challenges, and opportunities

Feng

Tang

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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With the continuous progress and development in biomedicine, metallic biomedical materials have attracted significant attention from researchers. Due to the low compatibility of traditional metal implant materials with the human body, it is urgent to develop new biomaterials with excellent mechanical properties and appropriate biocompatibility to solve the adverse reactions caused by long-term implantation. High entropy alloys (HEAs) are nearly equimolar alloys of five or more elements, with huge compositional design space and excellent mechanical properties. In contrast, biological high-entropy alloys (Bio-HEAs) are expected to be a new bio-alloy for biomedicine due to their excellent biocompatibility and tunable mechanical properties. This review summarizes the composition system of Bio-HEAs in recent years, introduces their biocompatibility and mechanical properties of human bone adaptation, and finally puts forward the following suggestions for the development direction of Bio-HEAs: to improve the theory and simulation studies of Bio-HEAs composition design, to quantify the influence of composition, process, post-treatment on the performance of Bio-HEAs, to focus on the loss of Bio-HEAs under actual service conditions, and it is hoped that the clinical application of the new medical alloy Bio-HEAs can be realized as soon as possible.

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Section: Mechanical Propertiesmentioning

confidence: 99%

Bio-high entropy alloys: Progress, challenges, and opportunities

Feng

Tang

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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“…In recent years, many clinical studies have focused on chronic wound treatment, such as PRP, bone marrow mesenchymal stem cells [ 47 , 48 ], transcutaneous electric nerve stimulations [ 49 ], and metallic dressing [ 50 , 51 , 52 ]. Among these treatments, PRP is an advanced method because of its pleasant effect, simple procedure, low cost, and safety [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

The Efficiency and Safety of Platelet-Rich Plasma Dressing in the Treatment of Chronic Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Xing

Yan

et al. 2023

JPM

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Recently, many clinical trials have applied platelet-rich plasma (PRP) dressings to treat wounds that have stopped healing, which are also called chronic wounds. However, the clinical efficiency of PRP dressings in treating chronic wounds is still controversial. Therefore, we conducted this study to compare PRP dressings with normal saline dressings in treating chronic wounds. Relevant randomized controlled trials focusing on utilizing PRP dressings in treating chronic wounds were extracted from bibliographic databases. Finally, 330 patients with chronic wounds, reported in eight randomized controlled trials, were included in this study. In total, 169 out of 330 (51.21%) were treated with PRP dressings, and 161 out of 330 (48.79%) were treated with normal saline dressings. The pooled results showed that the complete healing rate of the PRP group was significantly higher than that of saline group at 8 weeks and 12 weeks, respectively. In addition, there were no significant differences in wound infection and adverse events. Compared with normal saline dressing, the PRP dressing could effectively enhance the prognosis of chronic wounds. Furthermore, the PRP did not increase wound infection rate or occurrence of adverse events as an available treatment for chronic wounds.

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“…The TGF and PDGF could promote cell proliferation and migration during tissue healing, and bFGF plays a vital role in modulating cartilage regeneration [ 48 , 49 ]. These cytokines could inhibit chondrocyte apoptosis, promote chondrocyte proliferation, modulate local inflammation, and reconstruct bone and vessels [ 50 , 51 ]. In addition, other bioactive factors released by PRP contributed to tissue restoration [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Multiple Injections of Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Current Evidence in Randomized Controlled Trials

Xing

Yan

et al. 2023

JPM

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In recent years, various clinical trials have focused on treating knee osteoarthritis (KOA) with multiple injections of platelet-rich plasma (PRP). However, compared with the multiple hyaluronic acid (m-HA) injections, the clinical efficacy of multiple PRP (m-PRP) injections for KOA still remains controversial among these studies. Therefore,we aimed to compare the clinical effectiveness of m-PRP injections with m-HA injections in the treatment of KOA in this systematic review. Relevant clinical trials were searched via bibliographic databases, including Medline, PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials, to compare the m-PRP and m-HA injections in the treatment of KOA. Finally, fourteen randomized controlled trials, including 1512 patients, showed the postoperative VAS, WOMAC, IKDC, or EQ-VAS scores and were enrolled in this systematic review. Compared with the group of intra-articular m-HA injections, the group of intra-articular m-PRP injections was lower in the VAS scores at 3-month (WMD = −0.25; 95%CI, −0.40 to −0.10, P = 0.0009) and 12-month (WMD = −0.64; 95%CI, −0.79 to −0.49, p < 0.00001) follow-ups. In addition, the group of intra-articular m-PRP injections was also lower in the WOMAC scores at 1-month (WMD = −1.23; 95%CI, −2.17 to −0.29, p = 0.01), 3-month (WMD = −5.34; 95%CI, −10.41 to −0.27, p = 0.04), 6-month (WMD = −11.02; 95%CI, −18.09 to −3.95, p = 0.002), and 12-month (WMD = −7.69; 95%CI, −12.86 to −2.52, p = 0.004) follow-ups. Furthermore, compared with the group of intra-articular m-HA injections, the group of intra-articular m-PRP injections was higher in the IKDC scores at 3-month (WMD = 7.45; 95%CI, 2.50 to 12.40, p = 0.003) and 6-month (WMD = 5.06; 95%CI, 1.94 to 8.18, p = 0.001) follow-ups. However, the long-term adverse side of m-PRP injections for KOA still needs more large-scale trials and long-term follow-ups.

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Recent progress in Mg-based alloys as a novel bioabsorbable biomaterials for orthopedic applications

Cited by 85 publications

References 203 publications

Bio-high entropy alloys: Progress, challenges, and opportunities

Bio-high entropy alloys: Progress, challenges, and opportunities

The Efficiency and Safety of Platelet-Rich Plasma Dressing in the Treatment of Chronic Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Multiple Injections of Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Current Evidence in Randomized Controlled Trials

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