Recent Investigations on Vitiligo Vulgaris

Nordlund, James J.; Majumder, Partha P.

doi:10.1016/s0733-8635(05)70416-2

Cited by 50 publications

(49 citation statements)

References 79 publications

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“…Large, population-based studies have estimated the prevalence of vitiligo at 0.38-0.50% [3,4]. Approximately 20% of patients have a first-degree relative with the disease [5], and evidence suggests that vitiligo is inherited in a polygenic fashion [6]. Vitiligo has frequently been reported in association with autoimmune disorders such as thyroid disease, diabetes mellitus and alopecia areata.…”

Section: Discussionmentioning

confidence: 99%

Repigmentation of Vitiligo with Topical Tacrolimus

Smith

Tofte

Hanifin³

2002

Dermatology

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Section: Discussionmentioning

confidence: 99%

Repigmentation of Vitiligo with Topical Tacrolimus

Smith

Tofte

Hanifin³

2002

Dermatology

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“…It is frequent, having a prevalence rate in the general population of about 0.5% [1], and it can affect patients’ lives in a variety of ways consistent with perceived stigma [2]. The disorder might interfere negatively with sexual relationships [3], and a fairly high proportion of patients suffer substantial psychological distress [2, 4].…”

Section: Introductionmentioning

confidence: 99%

Stressful Life Events, Social Support, Attachment Security and Alexithymia in Vitiligo

Picardi

Pasquini

Cattaruzza

et al. 2003

Psychother Psychosom

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Background: It has often been suggested that stress might trigger vitiligo. However, only one study supported this hypothesis, and no study explored the role of other personality or social factors. Methods: Out-patients experiencing a recent onset or exacerbation of vitiligo (n = 31) were compared with out-patients with skin conditions in which psychosomatic factors are commonly were regarded as negligible (n = 116). Stressful events during the last 12 months were assessed with Paykel’s Interview for Recent Life Events. Attachment style, alexithymia and social support were assessed with the ‘Experiences in Close Relationships’ questionnaire, the Toronto Alexithymia Scale (TAS-20), and the Multidimensional Scale of Perceived Social Support, respectively. Results: Cases and controls did not differ regarding the total number of events and the number of undesirable, uncontrollable or major events. Three or more uncontrollable events had occurred more frequently among cases than controls. Perceived social support was lower in cases than in controls. Cases scored higher than controls on anxious attachment, tended towards higher scores on avoidant attachment and were classified more often as insecure. Cases scored higher than controls on the TAS-20 and were classified more often as alexithymic or borderline alexithymic. The occurrence of many uncontrollable events, alexithymia and anxious attachment were associated with vitiligo also in multiple logistic regression analysis. Conclusions: These findings suggest that vulnerability to vitiligo is not increased by stressful events, except for many uncontrollable events. Alexithymia, insecure attachment and poor social support appear to increase susceptibility to vitiligo, possibly through deficits in emotion regulation or reduced ability to cope effectively with stress.

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“…Active vitiligo usually requires medical therapy, which includes the use of psoralen, topical and oral administration of corticosteroids, khellin, or phenylalanine, along with UV-A radiation. [6][7][8][9][10][11]15,16 cal therapy entails melanocyte transplantation and is indicated when medical therapy fails, and it could actually be considered the first therapeutic choice for the treatment of stable vitiligo. Several methods of autologous melanocyte transplantation have been developed, including suction blister grafts, thin split-thickness skin…”

mentioning

confidence: 99%