Current Opinion in Hematology volume 18, issue 6, P436-442 2011 DOI: 10.1097/moh.0b013e32834bab01 View full text
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Ulrich J. Sachs

Abstract: Activated neutrophils are central in the pathophysiology of TRALI as their interaction with the lung endothelium causes capillary leak and pulmonary edema. Typically, numerous factors must act together in order to overcome a critical activation threshold of the neutrophil. At least one of these factors originates from a transfused blood component.