2013
DOI: 10.1039/c3lc50415h
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Abstract: Microfluidic devices can better control cellular microenvironments compared to conventional cell migration assays. Over the past few years, microfluidics-based chemotaxis studies showed a rapid growth. New strategies were developed to explore cell migration in manipulated chemical gradients. In addition to expanding the use of microfluidic devices for a broader range of cell types, microfluidic devices were used to study cell migration and chemotaxis in complex environments. Furthermore, high-throughput microf… Show more

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Cited by 127 publications
(107 citation statements)
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“…Recently developed, microfluidic systems allow the generation and maintenance of multiple gradients along different directions, thus providing a first step towards the modelling of complex gradients combinations in vitro (Xu and Heilshorn, 2013). Chemical gradient-based microfluidics are also used to understand homing mechanisms and responsiveness to soluble factors, which are intimately coordinated with the motile and recruitment capability of the stem cells (Wu et al, 2013).…”
Section: Microfluidics For Stem Cell Niches Modellingmentioning
confidence: 99%
“…Recently developed, microfluidic systems allow the generation and maintenance of multiple gradients along different directions, thus providing a first step towards the modelling of complex gradients combinations in vitro (Xu and Heilshorn, 2013). Chemical gradient-based microfluidics are also used to understand homing mechanisms and responsiveness to soluble factors, which are intimately coordinated with the motile and recruitment capability of the stem cells (Wu et al, 2013).…”
Section: Microfluidics For Stem Cell Niches Modellingmentioning
confidence: 99%
“…Its capacity is limited by poor gradient control and inability to visualize migrating cells (Keenan and Folch, 2008). Microfluidic devices, which can precisely configure gradient conditions, offer useful tools for cell migration and chemotaxis studies (Li and Lin, 2011;Wu et al, 2013). Previously, we used a microfluidic gradient generating device to study the migration of activated human peripheral blood T cells (ahPBT) (Lin and Butcher, 2006;Nandagopal et al, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Microfluidics-based migration assay supported measurements of cell migration in precisely defined chemical guiding fields. Highly diverse approaches have been explored for microfluidic gradient generation and chemotaxis studies [29][30][31][32], thus supporting further feasibility of creating novel microfluidic devices that will better mimic the complex compartmentalization and physiology of chemotactic factors in vitro. Understanding NK cell trafficking mechanism, particularly in inflamed peripheral sites, lymphoid tissues or tumor microenvironments will provide new insights into the development of NK cell-based therapeutic approaches against tumor and infections.…”
Section: Discussionmentioning
confidence: 99%
“…It is easier to control and manipulate the fluidic behaviors using microfluidic devices. The microfluidic device based cell-migration studies have been rapidly growing over the past decade [29][30][31][32]. Particularly relevant to our work in NK cell migration, Lin et al developed a simple "Y" shape microfluidic device for cell migration studies ( Figure 1) [33].…”
Section: A Simple Microfluidic System For Imaging Of Nk Cell Traffickingmentioning
confidence: 99%