Recent Advances on Bioactive Constituents in Ferula

Zhou, Yueting; Fang, Xin; Zhang, Guoqiang; Qu, Hexiang; Yang, Deok‐Chun; Han, Xiaoqiang

doi:10.1002/ddr.21402

Cited by 30 publications

(22 citation statements)

References 69 publications

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“…[2] Ferula species is a rich source of biologically active compounds, such as coumarins, sesquiterpenes, sesquiterpene coumarins, sesquiterpene lactones, and daucane esters. [3] As a result of many phytochemical studies, it has been reported that these seconder metabolites and the extracts from Ferula species showing biological properties including anti-diabetic, anti-fertility, antifungal, anti-inflammatory, antispasmodic, antitumor, antiviral, antiulcerogenic, cancer chemopreventive, digestive enzyme inhibition, hypotensive, and molluscicidal mutagenic. [4] According to our knowledge, there are limited investigations about Ferula elaeochytris in the literature.…”

Section: Introductionmentioning

confidence: 99%

Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

Deveci

Tel‐Çayan

Duru

2018

International Journal of Food Properties

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In this study, the antioxidant, anticholinesterase, and anti-tyrosinase properties of (hexane, acetone, methanol, and water) extracts of Ferula elaeochytris and Sideritis stricta were determined with the total phenolic and flavonoid contents. The phenolic profile of the methanol and water extracts was analysed using HPLC-DAD. Protocatechuic acid was found as the major phenolic compound in the methanol (116.3 ± 3.1 µg/g) and water extracts (69.4 ± 1.3 µg/g) of F. elaeochytris. Coumarins (253.9 ± 4.1 µg/g) and catechin hydrate (175.2 ± 2.9 µg/g) were the most abundant phenolic compounds in the methanol and water extracts of S. stricta. β-carotenelinoleic acid, DPPH • , ABTS •+ , CUPRAC, and metal-chelating assays were used to evaluate antioxidant properties of the extracts. The methanol and water extracts of F. elaeochytris and the acetone and methanol extracts of S. stricta containing the highest amount of total phenolic and flavonoid contents showed the highest antioxidant activities in β-carotene-linoleic acid, DPPH • , ABTS •+ , and CUPRAC assays. The enzyme inhibitory potential of extracts was investigated against key enzymes involved in neurodegenerative (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) and skin (tyrosinase) disorders. In the cholinesterase inhibitory assays, the hexane extracts of two species exhibited the best activity against AChE, while the hexane extract of F. elaeochytris and the methanol extract of S. stricta observed to be the most active against BChE. As for anti-tyrosinase activity results of extracts, the only acetone and methanol extracts showed mild inhibitory activity for both species.

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Section: Introductionmentioning

confidence: 99%

Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

Deveci

Tel‐Çayan

Duru

2018

International Journal of Food Properties

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“…Besides, Chattopadhyay et al (2009) reported that if SI values are 10 or greater than 10, antiviral results determined at or above this SI value may indicate that the extracts may have potential antiviral activity. Ferula species are rich in biologically active compounds, some of which are coumarins, sesquiterpenes, sesquiterpene coumarins, sesquiterpene lactones, and daucan esters (Zhou et al 2017). It was reported in many studies on phytochemicals that these secondary metabolites and extracts obtained from Ferula species can show anti-fertility, antifungal, antiinflammatory, antispasmodic, antitumor, antiviral, antiulcerogenic, cancer chemopreventive, digestive enzyme inhibition and hypotensive effects (Iranshahy & Iranshahi 2011).…”

Section: Cytotoxicity and Antiviral Assay Resultsmentioning

confidence: 99%

THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY

Doğan

Duman

2021

Trakya University Journal of Natural Sciences

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The trend towards natural products in the world is increasing due to the increased drug resistance of infectious diseases, the high prices for drugs and the difficulty of access. Also, bacterial or viral diseases that are difficult to treat and need a long time for proper treatment cause important infections in people. Since effective drugs could not be developed for most viral infections, it is very important to find natural products against viruses to introduce them to the world of science. The antiviral activities of the aqueous and methanol extract from Ferula halophila Peşmen, an endemic species to Turkey, has been investigated against human respiratory syncytial virus (HRSV, ATCC-VR-26). The cytotoxic and antiviral properties of plant extracts were investigated in HRSV / HEp-2 cell systems, respectively by the colorimetric MTT assay. In the study, the titer of RSV was used as 100 TCID50 (50% tissue culture infective dose). While MNTC (Maximum non-toxic concentration) of methanol extract was 195.313 µg/mL and CC50 (50% cytotoxic concentration) was 4366.22 µg/mL, it was determined as MNTC = 390.625 µg/mL and CC50 = 4366.22 for aqueous extract. According to the results, methanol extract showed more toxicity than the aqueous extract. The MNTC of Ribavirin used as a positive control was determined as 0.98 µg/mL and CC50 was 110.40 µg/mL. As a result of the study, it was determined that the methanol extract was not effective, whereas the aqueous extract had a significant anti-HRSV activity with the values of 50.69 µg/mL EC50 (50% Effective Concentration) and 97.54 Selectivity Index (SI). The EC50 and SI values of Ribavirin were 2.39 µg/mL and 46.19, respectively. According to the results, we can explain the presence of antiviral activity only in the aqueous extract and the absence in the methanol extract by the high toxicity of it and the insolubility of the antiviral compounds in the methanol extract. Özet: Dünyada doğal ürünlere yönelik eğilim, enfeksiyöz hastalıkların ilaç direncindeki artış, yüksek ilaç fiyatları ve erişim zorluğu nedeniyle artmaktadır. Ayrıca, tedavisi zor ve uzun süren bakteriyal veya viral hastalıklar insanlar üzerinde önemli enfeksiyonlara neden olur. Çoğu viral enfeksiyon için etkili bir ilaç geliştirilemediğinden, virüslere karşı doğal ürünlerin bulunması ve bilim dünyasına tanıtılması çok önemlidir. Bu amaçla, Türkiye'ye endemik bir tür olan Ferula halophila Peşmen'den elde edilen su ve metanol ekstrelerinin antiviral aktiviteleri, insan solunum sinsityal virüsüne (HRSV, ATCC-VR-26) karşı araştırılmıştır. Çalışmada, bitki ekstrelerinin sitotoksik ve antiviral özellikleri sırasıyla, HRSV/HEp-2 hücre sistemlerinde kolorimetrik MTT deneyi ile araştırılmıştır. RSV'nin titresi 100 DKID50 (%50 Doku kültürü infektif doz) olarak kullanılmıştır. Metanol ekstresinin MNTC'u (Maksimum non toksik konsantrasyon) 195,313 µg/mL ve CC50'u (%50 sitotoksik konsantrasyon) 4366,22 µg/mL, su ekstresinin ise MNTC'u 390,625 µg/mL ve CC50 4366,22 olarak belirlenmiştir. Sonuçlara göre metanol ekstresi su ekstre...

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“…Generally, aromatic acid lactones sesquiterpenes, coumarins, and sesquiterpene coumarins are present in the roots of Ferula species (Teng et al, 2013), whereas monoterpenes, oxygenated monoterpenoids sesquiterpenes and oxygenated sesquiterpenoid are the main chemical constituents of essential oil present in the aerial parts of Ferula (Mohammadhosseini et al, 2015). Due to the widespread therapeutic effects of this genus, it is being used in folk medicine to treat a variety of diseases and disorders, including skin infections, psychiatric disorders (especially seizure), hyperlipidemia, diabetes, arteries sclerosis, digestive disorders (dysentery), osteoporosis, arthritis, HIV, influenza type A, cancers (uterine cancer), muscle relaxant, rheumatism, headaches, hypertension, toothache and dizziness (Zhou et al, 2017;Meena et al, 2018;Arjmand and Dastan, 2020;Esmaeili et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)

Sonigra

Meena

2021

Front. Pharmacol.

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The genus Ferula is the third largest and a well-known genus of the Apiaceae family. It is categorized in the Peucedaneae tribe and Ferulinae subtribe of the Apiaceae family. At present, about 180 Ferula species have been reported. The genus is mainly distributed throughout central and South-West Asia (especially Iran and Afghanistan), the far-East, North India, and the Mediterranean. The genus Ferula is characterized by the presence of oleo-gum-resins (asafoetida, sagapenum, galbanum, and ammoniacum) and their use in natural and conventional pharmaceuticals. The main phytochemicals present in the genus Ferula are as follows: coumarin, coumarin esters, sesquiterpenes, sesquiterpene lactones, monoterpene, monoterpene coumarins, prenylated coumarins, sulfur-containing compounds, phytoestrogen, flavonoids and carbohydrates. This genus is considered to be a valuable group of medicinal plants due to its many different biological and pharmacological uses as volatile oils (essential oils). Numerous biological activities are shown by the chemical components of the essential oils obtained from different Ferula species. Because this genus includes many bioactivities such as antimicrobial, insecticidal, antioxidant, cytotoxic, etc., researchers are now focusing on this genus. Several reviews are already available on this particular genus, including information about the importance and the uses of all the phytochemicals found in the species of Ferula. Despite this, no review that specifically provides information about the biological activities of Ferula-derived essential oils, has been published yet. Therefore, the present review has been conducted to provide important information about the chemical profile, factors affecting the chemical composition, and biological activities of essential oils of the Ferula species.

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Recent Advances on Bioactive Constituents in Ferula

Cited by 30 publications

References 69 publications

Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts ofFerula elaeochytrisandSideritis stricta

THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY

Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)

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