Recent Advances of Poly(ether-ether) and Poly(ether-ester) Block Copolymers in Biomedical Applications

He, Zhi Yao; Shi, Kun; Wei, Yuquan; Zhang, Qian

doi:10.2174/1389200216666151103115944

Cited by 11 publications

(3 citation statements)

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“…Aside from that, PEG was proved to be difficult to metabolize naturally, and repeated injection of PEGylated preparations would reduce the bioactivity of loaded biomolecules due to the antibodies produced by immune system [7] . Additionally, the gene entrapment efficiency of PEGylated cationic liposomes would decrease due to the decline of positive charges [8] , [9] , [10] . Hence, it is necessary to find alternative materials that can not only resist biosorption during blood circulation but can also keep stable in different environment, be biodegraded via metabolism and have negligible immunogenicity other than PEG.…”

Section: Introductionmentioning

confidence: 99%

Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs

Zhou

Zhu

Wang

et al. 2020

Computational and Structural Biotechnology Journal

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Section: Introductionmentioning

confidence: 99%

Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs

Zhou

Zhu

Wang

et al. 2020

Computational and Structural Biotechnology Journal

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“…Moreover, PEG has been shown to be challenging to naturally metabolize, and multiple injections of PEGylated formulations can decrease the bioactivity of enclosed biomolecules because of antibodies generated by the immune system ( 34 ). The gene entrapment efficiency of PEGylated cationic liposomes would decrease because of the reduction in positive charges ( 35 ). Therefore, it is essential to identify alternative materials that can withstand biosorption during blood circulation, remain stable in various environments, be metabolized through biodegradation, and have minimal immunogenicity apart from PEG.…”

Section: Antifouling Materialsmentioning

confidence: 99%

Current status, challenges and prospects of antifouling materials for oncology applications

Zhang,

Sun

2024

Front. Oncol.

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Targeted therapy has become crucial to modern translational science, offering a remedy to conventional drug delivery challenges. Conventional drug delivery systems encountered challenges related to solubility, prolonged release, and inadequate drug penetration at the target region, such as a tumor. Several formulations, such as liposomes, polymers, and dendrimers, have been successful in advancing to clinical trials with the goal of improving the drug’s pharmacokinetics and biodistribution. Various stealth coatings, including hydrophilic polymers such as PEG, chitosan, and polyacrylamides, can form a protective layer over nanoparticles, preventing aggregation, opsonization, and immune system detection. As a result, they are classified under the Generally Recognized as Safe (GRAS) category. Serum, a biological sample, has a complex composition. Non-specific adsorption of chemicals onto an electrode can lead to fouling, impacting the sensitivity and accuracy of focused diagnostics and therapies. Various anti-fouling materials and procedures have been developed to minimize the impact of fouling on specific diagnoses and therapies, leading to significant advancements in recent decades. This study provides a detailed analysis of current methodologies using surface modifications that leverage the antifouling properties of polymers, peptides, proteins, and cell membranes for advanced targeted diagnostics and therapy in cancer treatment. In conclusion, we examine the significant obstacles encountered by present technologies and the possible avenues for future study and development.

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“…The incorporation of ceria nanoparticles into polymeric materials enables the enhancement of the mechanical properties and thermal stability of composites. As an example, poly(ether-ether) and poly(ether-ester) block copolymers have widely been applied in biomedicine due to their good safety and biocompatibility [51]; the introduction of CeO 2 nanoparticles into poly(ether-ester) enhances the mechanical, thermal and low-temperature elastic recovery properties and photostability of these polymers [52]. In turn, due to its high-performance characteristics, thermoplastic polyurethane (TPU) is widely used in advanced medical and healthcare products, such as diagnostic devices, artificial respiration units, healthcare mattresses, dental materials, compression stockings, medical instrument cables, gel shoe orthotics and wound dressings, etc.…”

Section: Cerium Oxide Nanoparticles As a Modifier Of Polymer Propertiesmentioning

confidence: 99%

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

et al. 2021

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The development of advanced composite biomaterials combining the versatility and biodegradability of polymers and the unique characteristics of metal oxide nanoparticles unveils new horizons in emerging biomedical applications, including tissue regeneration, drug delivery and gene therapy, theranostics and medical imaging. Nanocrystalline cerium(IV) oxide, or nanoceria, stands out from a crowd of other metal oxides as being a truly unique material, showing great potential in biomedicine due to its low systemic toxicity and numerous beneficial effects on living systems. The combination of nanoceria with new generations of biomedical polymers, such as PolyHEMA (poly(2-hydroxyethyl methacrylate)-based hydrogels, electrospun nanofibrous polycaprolactone or natural-based chitosan or cellulose, helps to expand the prospective area of applications by facilitating their bioavailability and averting potential negative effects. This review describes recent advances in biomedical polymeric material practices, highlights up-to-the-minute cerium oxide nanoparticle applications, as well as polymer-nanoceria composites, and aims to address the question: how can nanoceria enhance the biomedical potential of modern polymeric materials?

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Recent Advances of Poly(ether-ether) and Poly(ether-ester) Block Copolymers in Biomedical Applications

Abstract: Biodegradable, environment-sensitive and targeting moiety-functionalized block copolymers, which are being applied in active targeting theranostic systems, gene delivery systems and tissue engineering, are promising candidates for treatment of various diseases.

Cited by 11 publications

References 0 publications

Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs

Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs

Current status, challenges and prospects of antifouling materials for oncology applications

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

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