Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma

Wu, Hui; Zheng, Sihang; He, Qun; Li, Yan

doi:10.2147/ijgm.s380834

Cited by 6 publications

(5 citation statements)

References 63 publications

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“…Furthermore, tumor cells often utilize exosomes, robust components of intercellular communication, to improve their growth ( 16 , 18 ). Hence, exosome-derived biomarkers show tremendous promise and have been adopted in scientific research and clinics ( 16 , 18 – 20 ).…”

Section: Resultsmentioning

confidence: 99%

Extracellular vesicles as a new frontier of diagnostic biomarkers in osteosarcoma diseases: a bibliometric and visualized study

Pei,

Guo,

Wang

et al. 2024

Front. Oncol.

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The use of liquid biopsy in cancer research has grown exponentially, offering potential for early detection, treatment stratification, and monitoring residual disease and recurrence. Exosomes, released by cancer cells, contain tumor-derived materials and are stable in biofluids, making them valuable biomarkers for clinical evaluation. Bibliometric research on osteosarcoma (OS) and exosome-derived diagnostic biomarkers is scarce. Therefore, we aimed to conduct a bibliometric evaluation of studies on OS and exosome-derived biomarkers. Using the Web of Science Core Collection database, Microsoft Excel, the R “Bibliometrix” package, CiteSpace, and VOSviewer software, quantitative analyses of the country, author, annual publications, journals, institutions, and keywords of studies on exosome-derived biomarkers for OS from 1995 to 2023 were performed. High-quality records (average citation rate ≥ 10/year) were filtered. The corresponding authors were mainly from China, the USA, Australia, and Canada. The University of Kansas Medical Center, National Cancer Center, Japan, and University of Kansas were major institutions, with limited cooperation reported by the University of Kansas Medical Center. Keyword analysis revealed a shift from cancer progression to mesenchymal stem cells, exosome expression, biogenesis, and prognostic biomarkers. Qualitative analysis highlighted exosome cargo, including miRNAs, circRNAs, lncRNAs, and proteins, as potential diagnostic OS biomarkers. This research emphasizes the rapid enhancement of exosomes as a diagnostic frontier, offering guidance for the clinical application of exosome-based liquid biopsy in OS, contributing to the evolving landscape of cancer diagnosis.

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Section: Resultsmentioning

confidence: 99%

Extracellular vesicles as a new frontier of diagnostic biomarkers in osteosarcoma diseases: a bibliometric and visualized study

Pei,

Guo,

Wang

et al. 2024

Front. Oncol.

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“…Given the increasing potential clinical application of circRNAs in cancer as biomarkers and/or therapeutic targets, it might be a fruitful work to study the oncogenic role of these molecules in osteosarcoma. However, the research in this field is still relatively limited, compared to other tumors 150 . Several circRNAs reported in this review such as hsa_circ_0006766, circRNA_0001795, circPVT1, circRNA_0016624, circRNA_0048211, hsa_circ_0006215, circ_0006873, circRUNX2, hsa_circ_0006215, circ_0019693, hsa_circ_0006859, circ_0003865, hsa_circ_0076906 have been reported as involved in osteoporosis occurrence 9 , 49 , 77 - 79 , 90 , 112 , 123 , 125 , 127 , 154 , 155 .…”

Section: Future Perspectivesmentioning

confidence: 99%

“…Indeed, to the best of our knowledge, a few circRNAs including circRNA-28313, circRNA_009934, circ_ 0008542 and circ_0021739 have been reported as human osteoclastogenesis players [145][146][147][148]. Similarly, the knowledge behind the implication of dysregulated circRNAs in the initiation and progression of human bone diseases [149], such as osteosarcoma, osteoporosis and osteonecrosis is still in its early phases [150][151][152][153]. Given the increasing potential clinical application of circRNAs in cancer as biomarkers and/or therapeutic targets, it might be a fruitful work to study the oncogenic role of these molecules in osteosarcoma.…”

Section: Future Perspectivesmentioning

confidence: 99%

Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation

Mazziotta,

Badiale,

Cervellera

et al. 2024

Theranostics

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Human osteogenic differentiation is a complex and well-orchestrated process which involves a plethora of molecular players and cellular processes. A growing number of studies have underlined that circular RNAs (circRNAs) play an important regulatory role during human osteogenic differentiation. CircRNAs are single-stranded, covalently closed non-coding RNA molecules that are acquiring increased attention as epigenetic regulators of gene expression. Given their intrinsic high conformational stability, abundance, and specificity, circRNAs can undertake various biological activities in order to regulate multiple cellular processes, including osteogenic differentiation. The most recent evidence indicates that circRNAs control human osteogenesis by preventing the inhibitory activity of miRNAs on their downstream target genes, using a competitive endogenous RNA mechanism. The aim of this review is to draw attention to the currently known regulatory mechanisms of circRNAs during human osteogenic differentiation. Specifically, we provide an understanding of recent advances in research conducted on various human mesenchymal stem cell types that underlined the importance of circRNAs in regulating osteogenesis. A comprehensive understanding of the underlying regulatory mechanisms of circRNA in osteogenesis will improve knowledge on the molecular processes of bone growth, resulting in the potential development of novel preclinical and clinical studies and the discovery of novel diagnostic and therapeutic tools for bone disorders.

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“…Table 4 showcases some of the different types of non-coding RNA expressed in higher quantities in osteosarcoma. [41,67] Role of various types of non-coding RNAs in the different stages of osteosarcoma biology. circRNA = circular RNA, CSC = cancer Stem Cell, lncRNA = long non-coding RNA, miR = microRNA, and RNA = ribonucleic acid.…”

Section: Genomic Naturementioning

confidence: 99%

Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations

Al-Ansari,

Samuel,

Büsselberg

2024

Biomolecules

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Melatonin, an endogenous neurohormone produced by the pineal gland, has received increased interest due to its potential anti-cancer properties. Apart from its well-known role in the sleep–wake cycle, extensive scientific evidence has shown its role in various physiological and pathological processes, such as inflammation. Additionally, melatonin has demonstrated promising potential as an anti-cancer agent as its function includes inhibition of tumorigenesis, induction of apoptosis, and regulation of anti-tumor immune response. Although a precise pathophysiological mechanism is yet to be established, several pathways related to the regulation of cell cycle progression, DNA repair mechanisms, and antioxidant activity have been implicated in the anti-neoplastic potential of melatonin. In the current manuscript, we focus on the potential anti-cancer properties of melatonin and its use in treating and managing pediatric osteosarcoma. This aggressive bone tumor primarily affects children and adolescents and is treated mainly by surgical and radio-oncological interventions, which has improved survival rates among affected individuals. Significant disadvantages to these interventions include disease recurrence, therapy-related toxicity, and severe/debilitating side effects that the patients have to endure, significantly affecting their quality of life. Melatonin has therapeutic effects when used for treating osteosarcoma, attributed to its ability to halt cancer cell proliferation and trigger apoptotic cell death, thereby enhancing chemotherapeutic efficacy. Furthermore, the antioxidative function of melatonin alleviates harmful side effects of chemotherapy-induced oxidative damage, aiding in decreasing therapeutic toxicities. The review concisely explains the many mechanisms by which melatonin targets osteosarcoma, as evidenced by significant results from several in vitro and animal models. Nevertheless, if further explored, human trials remain a challenge that could shed light and support its utility as an adjunctive therapeutic modality for treating osteosarcoma.

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Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma

Cited by 6 publications

References 63 publications

Extracellular vesicles as a new frontier of diagnostic biomarkers in osteosarcoma diseases: a bibliometric and visualized study

Extracellular vesicles as a new frontier of diagnostic biomarkers in osteosarcoma diseases: a bibliometric and visualized study

Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation

Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations

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