Recent Advances of Biphasic Calcium Phosphate Bioceramics for Bone Tissue Regeneration

Kim, Sung Eun; Park, Kyeongsoon

doi:10.1007/978-981-15-3262-7_12

Cited by 44 publications

(30 citation statements)

References 99 publications

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“…Therefore, the use of CaP-based scaffolds with different formulations (HA, α- and β-TCPs, OCP, ACP, biphasic CaPs or a mixture of HA and β-TCP at varying ratios) have been considered an ideal artificial bone substitute. Their success relies on their biocompatibility, bioactivity, osteoinductivity and osteoconductivity abilities [ 22 , 23 ]. The mechanism behind the osteoinductive capacity of CaP-based composites has been addressed by a proteomic analysis, which revealed the implication of plasma cell glycoprotein 1 (PC-1), encoded by the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene ( ENPP1 ), which regulates the mineralization process by hydrolyzing adenosine triphosphate into adenosine monophosphate and pyrophosphate (PPi) [ 24 ].…”

Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.

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Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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“…The reason to use TCP for bone substitutes is the faster degradability [46] even though bone tissue is predominantly composed of HA [47]. Following the healing process of the scaffold-treated defect by bony bridging, a gradual degradation of the scaffold is needed for creeping substitution.…”

Section: Discussionmentioning

confidence: 99%

3D-Printed HA-Based Scaffolds for Bone Regeneration: Microporosity, Osteoconduction and Osteoclastic Resorption

et al. 2022

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Additive manufacturing enables the realization of the macro- and microarchitecture of bone substitutes. The macroarchitecture is determined by the bone defect and its shape makes the implant patient specific. The preset distribution of the 3D-printed material in the macroarchitecture defines the microarchitecture. At the lower scale, the nanoarchitecture of 3D-printed scaffolds is dependent on the post-processing methodology such as the sintering temperature. However, the role of microarchitecture and nanoarchitecture of scaffolds for osteoconduction is still elusive. To address these aspects in more detail, we produced lithography-based osteoconductive scaffolds from hydroxyapatite (HA) of identical macro- and microarchitecture and varied their nanoarchitecture, such as microporosity, by increasing the maximum sintering temperatures from 1100 to 1400 °C. The different scaffold types were characterized for microporosity, compression strength, and nanoarchitecture. The in vivo results, based on a rabbit calvarial defect model showed that bony ingrowth, as a measure of osteoconduction, was independent from scaffold’s microporosity. The same applies to in vitro osteoclastic resorbability, since on all tested scaffold types, osteoclasts formed on their surfaces and resorption pits upon exposure to mature osteoclasts were visible. Thus, for wide-open porous HA-based scaffolds, a low degree of microporosity and high mechanical strength yield optimal osteoconduction and creeping substitution. Based on our study, non-unions, the major complication during demanding bone regeneration procedures, could be prevented.

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“…The BCP scaffold composed of HA/β-TCP has been proven to be highly biocompatible and can promote the attachment, differentiation, and proliferation of osteoblasts [1,32]. In a study by Tang et al, two different BCP with β-TCP to HA ratios of 30/70 and 70/30 were investigated and BCP with β-TCP to HA ratio of 70/ 30 showed earlier and significantly higher expression of osteogenesis-related genes [33].…”

Section: Discussionmentioning

confidence: 99%

Loading of erythropoietin on biphasic calcium phosphate bioceramics promotes osteogenesis and angiogenesis by regulating EphB4/EphrinB2 molecules

Wang

et al. 2022

J Mater Sci: Mater Med

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Improving osteogenesis and angiogenesis using different cells and drugs is critical in the field of bone tissue engineering. Recent research has found that erythropoietin (EPO) plays an important role in both osteogenesis and angiogenesis. In this study, we grafted polydopamine and EPO onto the surface of biphasic calcium phosphate. The characterization and release property of the modified bioceramics were assessed. Cell proliferation, expression of osteoblastic and endothelial markers, and EphB4/EphrinB2 molecules were investigated while employing co-cultures of two different cells [rat vein endothelial cells (VECs) and rat bone marrow mesenchymal stromal cells (BMSCs)]. The modified bioceramics were finally implanted into the SD rats’ femurs and followed by investigating the bone defect repair efficacy and the expression of EphB4/EphrinB2 molecules in vivo. The results indicated that the modified bioceramics could control the release of EPO continuously. The osteogenesis and angiogenesis were improved along with the increased expression of EphB4/EphrinB2 molecules. The expression of EphB4/EphrinB2 molecules was also significantly increased in vivo and the bone defect was repaired effectively. Overall, our findings demonstrated that EPO loading on biphasic calcium phosphate bioceramics could promote both osteogenesis and angiogenesis. The results suggest that EphB4/EphrinB2 may be crucial in the process.

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Recent Advances of Biphasic Calcium Phosphate Bioceramics for Bone Tissue Regeneration

Cited by 44 publications

References 99 publications

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

3D-Printed HA-Based Scaffolds for Bone Regeneration: Microporosity, Osteoconduction and Osteoclastic Resorption

Loading of erythropoietin on biphasic calcium phosphate bioceramics promotes osteogenesis and angiogenesis by regulating EphB4/EphrinB2 molecules

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