2015
DOI: 10.4254/wjh.v7.i24.2503
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Abstract: Hepatitis B virus (HBV) infection is a global health problem. It is estimated there are more than 2 billion individuals exposed to the virus and 250 million are chronically infected. Hepatitis B is the cause of more than 600000 annual deaths due to cirrhosis and hepatocellular carcinoma. An effective vaccine exists and preventative initiatives center around universal vaccination especially in those at highest risk. Effective vaccination algorithms have led to a significant decline in the development of new inf… Show more

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Cited by 84 publications
(93 citation statements)
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“…The yeast produces only the noninfectious HBsAg, eliminating the risk of viral DNA insertion into the human organism . The administration of the vaccine has as a result an interaction with the antigen presenting cells (HBsAg‐specific B cells) . Subsequently, the epitope complexed with MHC class II molecules is presented to T helper 2 cells .…”
Section: Hepatitis B Vaccine–induced Immune Responsementioning
confidence: 99%
See 2 more Smart Citations
“…The yeast produces only the noninfectious HBsAg, eliminating the risk of viral DNA insertion into the human organism . The administration of the vaccine has as a result an interaction with the antigen presenting cells (HBsAg‐specific B cells) . Subsequently, the epitope complexed with MHC class II molecules is presented to T helper 2 cells .…”
Section: Hepatitis B Vaccine–induced Immune Responsementioning
confidence: 99%
“…The administration of the vaccine has as a result an interaction with the antigen presenting cells (HBsAg‐specific B cells) . Subsequently, the epitope complexed with MHC class II molecules is presented to T helper 2 cells . The T helper 2 cells' activation results in the differentiation of B cells into plasma cells that are able to produce anti‐HBs and promote the development of memory B and T cells .…”
Section: Hepatitis B Vaccine–induced Immune Responsementioning
confidence: 99%
See 1 more Smart Citation
“… Additional dose(s) at varying times; Repeating the standard 3‐dose schedule at 0, 1 and 6 months; Double the dose; Brand of vaccine with higher antigen content; Intradermal administration; Oral, nasal or combined vaccine …”
Section: Introductionmentioning
confidence: 99%
“…Given the shared risk factors for transmission, co-infection of hepatitis B virus (HBV) with HCV is quite common, and may lead to more significant liver disease [9] . A recent review by [10] mentioned that: "Individuals with chronic disease states such as kidney disease, liver disease, diabetes mellitus, as well as those with a genetic predisposition, and those on immunomodulation therapy, have the highest likelihood of nonresponse. Various strategies have been developed to elicit an immune response in these individuals.…”
Section: Discussionmentioning
confidence: 99%